Investigating the effect of a stress-based uniaxial anisotropy on the magnetic behaviour of La_0.7Sr_0.3MnO₃ elements

We investigate the interplay between shape anisotropy and a stress-based uniaxial anisotropy on the magnetic domain structure of La<sub>0.7</sub>Sr<sub>0.3</sub>MnO<sub>3</sub> nanoelements as a function of aspect ratio, using micromagnetic simulations. We show that a direct competition between the anisotropies gives rise to high energy multi-domain flux closure configurations, whilst an alignment of the anisotropies can modify the effective element dimensions and act to stabilise a single domain configuration. Our results demonstrate the ability to control the spin state of La<sub>0.7</sub>Sr<sub>0.3</sub>MnO<sub>3</sub> elements in addition to tailoring the domain wall width by controlling the anisotropy of the material, which is key for spintronic applications that require a high spin-polarization and stable magnetic configurations

A Three-dimensional Deformable Brain Atlas for DBS Targeting. I. Methodology for Atlas Creation and Artifact Reduction.

BackgroundTargeting in deep brain stimulation (DBS) relies heavily on the ability to accurately localize particular anatomic brain structures. Direct targeting of subcortical structures has been limited by the ability to visualize relevant DBS targets.Methods and resultsIn this work, we describe the development and implementation, of a methodology utilized to create a three dimensional deformable atlas for DBS surgery. This atlas was designed to correspond to the print version of the Schaltenbrand-Bailey atlas structural contours. We employed a smoothing technique to reduce artifacts inherent in the print version.ConclusionsWe present the methodology used to create a three dimensional patient specific DBS atlas which may in the future be tested for clinical utility

Prevailing Arguments and Types of Conclusions of Parent\u2013Child Argumentation

This chapter examines the types of arguments used most often by parents and children and the different types of conclusions of their argumentative discussions. The conceptual tool adopted for the analysis is based on the integration of the pragma-dialectical ideal model of a critical discussion (van Eemeren & Grootendorst, 2004) with the Argumentum Model of Topics (Rigotti & Greco Morasso, 2019). The integration of these two tools of analysis permits to reconstruct the inferential configuration of the arguments used by parents and children and to identify the types of conclusions of their argumentative discussions. Exemplary argumentative sequences that bring to light the results obtained through the qualitative analysis of a larger corpus of argumentative discussions between parents and children are presented and discussed

investigation of integrated organic rankine cycles and wind turbines for micro scale applications

Abstract The aim of this work is the investigation of the performance of an innovative biomass/wind energy integrated system for Combined Heat and Power (CHP) generation in small-scale applications. The system is based on an Organic Rankine Cycle (ORC) fed with biomass and a wind turbine (WT). The ORC and WT sub-systems operate in parallel to produce the required electrical energy and an auxiliary boiler provides thermal energy if the CHP output is low. A preliminary investigation is performed to define the proper size of the wind turbine. Afterwards, the analysis is focused on the integrated system. In particular, the application to the Italian residential sector is analysed. Results illustrate that hybridisation improves the global conversion efficiency, by reducing the biomass consumption and overcoming the intermittency of the wind source. When the wind source is significant, the ORC system can be switched off or operated at partial load

Analysis of multi-source energy system for small-scale domestic applications. Integration of biodiesel, solar and wind energy

The paper aims at analysing the energy performance of an innovative multi-source energy system for residential small-scale combined heat and power (CHP) applications. The integrated system is based on an Organic Rankine Cycle (ORC) fuelled by biodiesel, a wind turbine, and a photovoltaic unit. The application refers to the Italian residential sector. The ORC system operates in order to satisfy the thermal demand of domestic users while wind and solar based sub-systems work in parallel to increase the electric self-consumption rate. An auxiliary boiler provides thermal energy when the CHP thermal output is low. Furthermore, when the solar and/or wind sources are significant, the ORC can be switched-off or operated at partial load.A preliminary investigation is performed to define the proper size of the ORC unit. Afterwards, the analysis is focused on a multi-variable optimisation of the integrated system. In particular, the nominal power of the wind turbine and photovoltaic units have been found in order to guarantee a proper trade-off between electric self-consumed and surplus energy. Keywords: Biodiesel, Combined heat and power, Multi-source generation, Organic Rankine cycle, Solar, Win

The central role of endothelium in hereditary angioedema due to C1 inhibitor deficiency

An impairment of the endothelial barrier function underlies a wide spectrum of pathological conditions. Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) can be considered the \u201cpathophysiological and clinical paradigm\u201d of Paroxysmal Permeability Diseases (PPDs), conditions characterized by recurrent transient primitively functional alteration of the endothelial sieving properties, not due to inflammatory-ischemic-degenerative injury and completely reversible after the acute flare. It is a rare yet probably still underdiagnosed disease which presents with localized, non-pitting swelling of the skin and submucosal tissues of the upper respiratory and gastrointestinal tracts, without significant wheals or pruritus. The present review addresses the pathophysiology of C1-INH-HAE with a focus on the crucial role of the endothelium during contact and kallikrein/kinin system (CAS and KKS) activation, currently available and emerging biomarkers, methods applied to get new insights into the mechanisms underlying the disease (2D, 3D and in vivo systems), new promising investigation techniques (autonomic nervous system analysis, capillaroscopy, flow-mediated dilation method, non-invasive finger plethysmography). Hints are given to the binding of C1-INH to endothelial cells. Finally, crucial issues as the local vs systemic nature of CAS/KKS activation, the episodic nature of attacks vs constant C1-INH deficiency, pros and cons as well as future perspectives of available methodologies are briefly discussed

Intraocular pressure changes during femtosecond laser-assisted cataract surgery: A comparison between two different patient interfaces

Purpose. The aim of this retrospective cohort study was to evaluate intraocular pressure (IOP) changes during femtosecond laser-assisted cataract surgery (FLACS) using two different patient interface systems. Methods. 116 eyes of 116 patients scheduled for cataract surgery were divided into 2 groups: group 1 (61 eyes) and group 2 (55 eyes) underwent FLACS using Catalys Laser with fluid interface (liquid optics interface, LOI) and LenSx Laser with curved interface and soft contact lens (SoftFit), respectively. IOP was assessed using a portable rebound tonometer (Icare\uae) preoperatively, after docking, immediately after surgery, at one and seven days postoperatively. Results. In group 1, the mean IOP (\ub1SD) was 14.1 \ub1 0.4 mmHg before surgery, 33.2 \ub1 1.1 mmHg after docking, and 21.4 \ub1 0.9 mmHg immediately after surgery. In group 2, the mean IOP was 13.8 \ub1 0.4 mmHg before surgery, 24.2 \ub1 1.4 mmHg after docking, and 20.2 \ub1 1.2 mmHg immediately after surgery. After the docking procedure, a statistically significant increase in IOP from the baseline was found in both groups (p0.05) using both laser platforms. No intraoperative and postoperative complications were observed. Conclusions. FLACS suction phase resulted in a transient increase of IOP in both groups, especially with the LOI system, and it is probably related to the greater pressure of a suction ring and suction generated through the vacuum, independently from the effect of femtosecond laser itself

Pathological implications of Th1/Th2 cytokine genetic variants in Beh\ue7et's disease: Data from a pilot study in a Sicilian population

Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) seem to be involved in the pathophysiology of Beh\ue7et's disease, a chronic immune-mediated disease characterized by oral and genital lesions and ocular inflammation. Its individual susceptibility seems to be modulated by genetic variants in genes codifying these cytokines. Th1 and Th17 seem to be involved in the disease's active phases, and Th2 seems to affect the development or severity of the disease; however, contrasting data are reported. In this study, some genetic variants of the Th1/Th2 cytokine genes were investigated in Sicilian patients and age- and gender-matched controls. Three very significant associations with Beh\ue7et's disease were detected, and combined genotypes associated with increased disease risk were identified. Results obtained point to the key role of Th1/Th2 cytokine genetic variants in disease susceptibility

Episodic angioedema with hypereosinophilia (Gleich’s syndrome): A case report and extensive review of the literature

Episodic angioedema with eosinophilia (EAE) (Gleich’s syndrome) is a rare disease charac-terized by hypereosinophilia (up to 95 × 109 cells/L), recurrent episodes of angioedema, urticaria, weight gain, and fever, that occur at periodical intervals (usually every 3–4 weeks). The exact etiology of EAE is still unclear, but both eosinophils and abnormalities of cytokines homeostasis seem to play a pivotal role in the pathogenesis of the disease. In particular, the cyclic elevation of serum interleukin-5 before the increase in eosinophil count has been reported. Herein, we performed a broad literature review and report the case of a thirty-two-year-old woman with a two-year history of cyclic angioedema attacks, urticaria, periodic weight gain, and severe hypereosinophilia, diagnosed with EAE and treated with oral corticosteroids. Describing the most relevant clinical features of EAE reported so far in the literature, we aim to provide physicians with some useful tools to help them deal with this disease. In addition, we aim to raise awareness about this rare condition in which approved diagnostic classification criteria are currently missing