Draft Genome Sequence of the Serratia rubidaea CIP 103234T Reference Strain, a Human-Opportunistic Pathogen.

We provide here the first genome sequence of a Serratia rubidaea isolate, a human-opportunistic pathogen. This reference sequence will permit a comparison of this species with others of the Serratia genus

Whole-Genome Sequence of a European Clone II and OXA-72-Producing Acinetobacter baumannii Strain from Serbia.

We report here the draft genome sequence of a carbapenem-resistant Acinetobacter baumannii strain isolated from a patient, a strain which previously stayed in Serbia. This isolate possessed the blaOXA-72 carbapenemase gene. The draft genome sequence consists of a total length of 3.91 Mbp, with an average G+C content of 38.8%

Cervical cancer metastasis to the brain: A case report and review of literature

Background: Intracranial metastasis from cervical cancer is a rare occurrence. Methods: In this study we describe a case of cervical cancer metastasis to the brain and perform an extensive review of literature from 1956 to 2016, to characterize clearly the clinical presentation, treatment options, molecular markers, targeted therapies, and survival of patients with this condition. Results: An elderly woman with history of cervical cancer in remission, presented 2 years later with a right temporo-parietal tumor, which was treated with surgery and subsequent stereotactic radiosurgery (SRS) to the resection cavity. She then returned 5 months later with a second solitary right lesion; she again underwent surgery and SRS to the resection cavity with no signs of recurrence 6 months later. According to the reviewed literature, the most common clinical presentation included females with median age of 48 years; presenting symptoms such as headache, weakness/hemiplegia/hemiparesis, seizure, and altered mental status (AMS)/confusion; multiple lesions mostly supratentorially located; poorly differentiated squamous cell carcinoma; and additional recurrences at other sites. The best approach to treatment is a multimodal plan, consisting of SRS or whole brain radiation therapy (WBRT) for solitary brain metastases followed by chemotherapy for systemic disease, surgery and WBRT for solitary brain lesions without systemic disease, and SRS or WBRT followed by chemotherapy for palliative care. The overall prognosis is poor with a mean and median survival time from diagnosis of brain metastasis of 7 and 4.6 months, respectively. Conclusion: Future efforts through large prospective randomized trials are warranted to better describe the clinical presentation and identify more effective treatment plans

Evaluation of the environmental impacts of suckler calf-to-beef mixedcrop-livestock farms in northern Italy: A farm-based study

The issue of the environmental impacts of beef production has been extensively debated in recent years. However, the research on this theme has mainly been based on farm-model studies with limited attention to contribution analysis of impact categories and aspects linked to cropping systems and feed self-sufficiency in mixed crop-livestock farms. This study evaluated the cradle-tofarm gate environmental impacts of mixed-crop livestock farms rearing the Piedmontese beef breed and suckler calf-to-beef operations in Northwest Italy. Data have been collected from detailed on-farm questionnaires, field books, and invoices of 11 farms over two years (2017-2018). The environmental impacts have been evaluated in terms of land occupation (LO, m2/year), global warming potential (GWP, kg CO2-eq), acidification potential (AP, g SO2-eq) and non-renewable cumulative energy demand (CED, MJ), using life cycle assessment methodology. The functional unit considered was one kilogram of live weight produced at the farm gate. The Piedmontese beef production system showed comparable average environmental impacts with those found in other studies, even though high variability was observed in the studied farms. The GWP averaged 15.7 kg of CO2 eq/kg LW and ranged from 12.1 to 17.6 kg of CO2 eq/kg LW. The CED, LO and AP were on average 62.4 MJ/kg LW, 18.5 m2/y/kg LW and 305 g SO2 eq/kg LW, respectively. Differences in environmental impacts and GWP contribution analysis were mainly due to differences in cropping system management strategies and the consequent levels of feed self-sufficiency. A positive effect of high fertility and animal productivity was observed on the GWP (r=0.62; P<0.01), highlighting the importance of improving efficiency of these aspects for the reduction of emissions. From the contribution analysis of impact categories, the high cost of purchased feeds (in particular protein feeds), transport, and mineral fertilizers for feed production were highly relevant. However further research is needed to confirm these findings. Highlights - Study of 11 farms for two years. - High relevance of purchased feeds on environmental impacts. - Productive and reproductive performances are key points in reducing environmental impacts. - Importance of the valorisation of farm crop surfaces to satisfy animals' needs