Integrated optical directional coupler biosensor

We present measurements on biomolecular binding reactions, using a new type of integrated optical biosensor based on a planar directional coupler structure. The device is fabricated by Ag+-Na+ ion-exchange in glass and definition of the sensing region is achieved by use of transparent fluoropolymer isolation layers formed by thermal evaporation. The suitability of the sensor for application to the detection of environmental pollutants is considered

Organizational Violations of Externally Governed Privacy and Security Rules: Explaining and Predicting Selective Violations under Conditions of Strain and Excess

Privacy and security concerns are pervasive because of the ease of access to information. Recurrent negative cases in the popular press attest to the failure of current privacy regulations to keep consumer and protected health information sufficiently secure in today’s climate of increased IT use. One reason for such failure is that organizations violate these regulations for multiple reasons. To address this issue, we propose a theoretical model to explain the likelihood that organizations will select an externally governed privacy or security rule for violation in response to organizational strain or slack resources. Our proposed theoretical model, the selective organizational information privacy and security violations model (SOIPSVM), explains how organizational structures and processes, along with characteristics of regulatory rules, alter perceptions of risk when an organization’s performance does not match its aspiration levels and, thereby, affects the likelihood of rule violations. Importantly, we contextualize SOIPSVM to organizational privacy and security violations. SOIPSVM builds on and extends the selective organizational rule violations model (SORVM), which posits that organizational rule violations are selective. SOIPSVM provides at least four contributions to the privacy and security literature that can further guide empirical research and practice. First, SOIPSVM introduces the concept of selectivity in rule violations to privacy and security research. This concept can improve privacy and security research by showing that organizational violations of privacy and security rules are dynamic and selective yet influenced by external forces. Second, SOIPSVM extends the boundaries of SORVM, which is limited to explaining the behavior of organizations under strain, such as economic hardship. We contribute to the theory of selective deviance by proposing that selectivity extends to organizations with slack resources. Third, we address ideas of non-economic risk and strain in addition to economic risk and strain. Thus, SOIPSVM explains organizational rule-violating behavior as an attempt to protect core organizational values from external entities that pressure organizations to change their values to comply with rules. Fourth, we broaden the theoretical scope of two important constructs (namely, structural secrecy and procedural emphasis) to improve the model’s explanatory power. Fifth, we identify important elements of rule enforcement by drawing from the tenets of general deterrence theory. We also discuss how one can study constructs from general deterrence theory at the organizational level. To conclude, we offer recommendations for the structuring of organizations and external regulations to decrease organizational rule violations, which often lead to the abuse of consumer information

Compensation of Strong Thermal Lensing in High Optical Power Cavities

In an experiment to simulate the conditions in high optical power advanced gravitational wave detectors such as Advanced LIGO, we show that strong thermal lenses form in accordance with predictions and that they can be compensated using an intra-cavity compensation plate heated on its cylindrical surface. We show that high finesse ~1400 can be achieved in cavities with internal compensation plates, and that the cavity mode structure can be maintained by thermal compensation. It is also shown that the measurements allow a direct measurement of substrate optical absorption in the test mass and the compensation plate.Comment: 8 page

Interactions of asbestos-activated macrophages with an experimental fibrosarcoma

Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro

Huddle test measurement of a near Johnson noise limited geophone

In this paper, the sensor noise of two geophone configurations (L-22D and L-4C geophones from Sercel with custom built amplifiers) was measured by performing two huddle tests. It is shown that the accuracy of the results can be significantly improved by performing the huddle test in a seismically quiet environment and by using a large number of reference sensors to remove the seismic foreground signal from the data. Using these two techniques, the measured sensor noise of the two geophone configurations matched the calculated predictions remarkably well in the bandwidth of interest (0.01 Hz–100 Hz). Low noise operational amplifiers OPA188 were utilized to amplify the L-4C geophone to give a sensor that was characterized to be near Johnson noise limited in the bandwidth of interest with a noise value of 10−11 m/Hz⎯⎯⎯⎯⎯√10−11 m/Hz at 1 Hz

Passive-performance, analysis, and upgrades of a 1-ton seismic attenuation system

The 10m Prototype facility at the Albert-Einstein-Institute (AEI) in Hanover, Germany, employs three large seismic attenuation systems to reduce mechanical motion. The AEI Seismic-Attenuation-System (AEI-SAS) uses mechanical anti-springs in order to achieve resonance frequencies below 0.5Hz. This system provides passive isolation from ground motion by a factor of about 400 in the horizontal direction at 4Hz and in the vertical direction at 9Hz. The presented isolation performance is measured under vacuum conditions using a combination of commercial and custom-made inertial sensors. Detailed analysis of this performance led to the design and implementation of tuned dampers to mitigate the effect of the unavoidable higher order modes of the system. These dampers reduce RMS motion substantially in the frequency range between 10 and 100Hz in 6 degrees of freedom. The results presented here demonstrate that the AEI-SAS provides substantial passive isolation at all the fundamental mirror-suspension resonances