5,230 research outputs found
Epitaxial Growth of an n-type Ferromagnetic Semiconductor CdCr2Se4 on GaAs(001) and GaP(001)
We report the epitaxial growth of CdCr2Se4, an n-type ferromagnetic
semiconductor, on both GaAs and GaP(001) substrates, and describe the
structural, magnetic and electronic properties. Magnetometry data confirm
ferromagnetic order with a Curie temperature of 130 K, as in the bulk material.
The magnetization exhibits hysteretic behavior with significant remanence, and
an in-plane easy axis with a coercive field of ~125 Oe. Temperature dependent
transport data show that the films are semiconducting in character and n-type
as grown, with room temperature carrier concentrations of n ~ 1 x 10^18 cm-3.Comment: 12 pages, 3 figure
Development of the Ranger Block III SPACECRAFT propulsion system
Design, development, and flight operation of midcourse propulsion system used on Ranger Block III spacecraf
Orbital operations study. Appendix B: Operational procedures
Operational procedures for each alternate approach for each interfacing activity of the orbital operations study are presented. The applicability of the procedures to interfacing element pairs is identified
Spin-dependent electrical transport in ion-beam sputter deposited Fe-Cr multilayers
The temperature dependence of the electrical resistivity and
magnetoresistance of Xe-ion beam sputtered Fe-Cr multilayers has been
investigated. The electrical resistivity between 5 and 300 K in the fully
ferromagnetic state, obtained by applying a field beyond the saturation field
(H_sat) necessary for the antiferromagnetic(AF)-ferromagnetic(FM) field-induced
transition, shows evidence of spin-disorder resistivity as in crystalline Fe
and an s-d scattering contribution (as in 3d metals and alloys). The sublattice
magnetization m(T) in these multilayers has been calculated in terms of the
planar and interlayer exchange energies. The additional spin-dependent
scattering \Delta \rho (T) = \rho(T,H=0)_AF - \rho(T,H=H_sat)_FM in the AF
state over a wide range of temperature is found to be proportional to the
sublattice magnetization, both \Delta \rho(T) and m(T) reducing along with the
antiferromagnetic fraction. At intermediate fields, the spin-dependent part of
the electrical resistivity (\rho_s (T)) fits well to the power law \rho_s (T) =
b - cT^\alpha where c is a constant and b and \alpha are functions of H. At low
fields \alpha \approx 2 and the intercept b decreases with H much the same way
as the decrease of \Delta \rho (T) with T. A phase diagram (T vs. H_sat) is
obtained for the field- induced AF to FM transition. Comparisons are made
between the present investigation and similar studies using dc magnetron
sputtered and molecular beam epitaxy (MBE) grown Fe-Cr multilayers.Comment: 8 pages, 10 figures, to appear in Phys. Rev.
Non-Newtonian fluid flow through three-dimensional disordered porous media
We investigate the flow of various non-Newtonian fluids through
three-dimensional disordered porous media by direct numerical simulation of
momentum transport and continuity equations. Remarkably, our results for
power-law (PL) fluids indicate that the flow, when quantified in terms of a
properly modified permeability-like index and Reynolds number, can be
successfully described by a single (universal) curve over a broad range of
Reynolds conditions and power-law exponents. We also study the flow behavior of
Bingham fluids described in terms of the Herschel-Bulkley model. In this case,
our simulations reveal that the interplay of ({\it i}) the disordered geometry
of the pore space, ({\it ii}) the fluid rheological properties, and ({\it iii})
the inertial effects on the flow is responsible for a substantial enhancement
of the macroscopic hydraulic conductance of the system at intermediate Reynolds
conditions. This anomalous condition of ``enhanced transport'' represents a
novel feature for flow in porous materials.Comment: 5 pages, 5 figures. This article appears also in Physical Review
Letters 103 194502 (2009
Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice
Dysregulation of calcium signaling has been causally implicated in brain aging and Alzheimer's disease. Mutations in the presenilin genes (PS1, PS2), the leading cause of autosomal dominant familial Alzheimer's disease (FAD), cause highly specific alterations in intracellular calcium signaling pathways that may contribute to the neurodegenerative and pathological lesions of the disease. To elucidate the cellular mechanisms underlying these disturbances, we studied calcium signaling in fibroblasts isolated from mutant PS1 knockin mice. Mutant PS1 knockin cells exhibited a marked potentiation in the amplitude of calcium transients evoked by agonist stimulation. These cells also showed significant impairments in capacitative calcium entry (CCE, also known as store-operated calcium entry), an important cellular signaling pathway wherein depletion of intracellular calcium stores triggers influx of extracellular calcium into the cytosol. Notably, deficits in CCE were evident after agonist stimulation, but not if intracellular calcium stores were completely depleted with thapsigargin. Treatment with ionomycin and thapsigargin revealed that calcium levels within the ER were significantly increased in mutant PS1 knockin cells. Collectively, our findings suggest that the overfilling of calcium stores represents the fundamental cellular defect underlying the alterations in calcium signaling conferred by presenilin mutations
Publication and patent analysis of European researchers in the field of production technology and manufacturing systems
This paper develops a structured comparison among a sample of European researchers in the field of Production Technology and Manufacturing Systems, on the basis of scientific publications and patents. Researchers are evaluated and compared by a variegated set of indicators concerning (1) the output of individual researchers and (2) that of groups of researchers from the same country. While not claiming to be exhaustive, the results of this preliminary study provide a rough indication of the publishing and patenting activity of researchers in the field of interest, identifying (dis)similarities between different countries. Of particular interest is a proposal for aggregating analysis results by means of maps based on publication and patent indicators. A large amount of empirical data are presented and discusse
An Intact Kidney Slice Model to Investigate Vasa Recta Properties and Function in situ
Background: Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta when vasoactive substances are present. We describe a live kidney slice model in which pericyte-mediated vasa recta constriction/dilation can be visualized in situ. Methods: Confocal microscopy was used to image calcein, propidium iodide and Hoechst labelling in ‘live’ kidney slices, to determine tubular and vascular cell viability and morphology. DIC video-imaging of live kidney slices was employed to investigate pericyte-mediated real-time changes in vasa recta diameter. Results: Pericytes were identified on vasa recta and their morphology and density were characterized in the medulla. Pericyte-mediated changes in vasa recta diameter (10–30%) were evoked in response to bath application of vasoactive agents (norepinephrine, endothelin-1, angiotensin-II and prostaglandin E2) or by manipulating endogenous vasoactive signalling pathways (using tyramine, L-NAME, a cyclo-oxygenase (COX-1) inhibitor indomethacin, and ATP release). Conclusions: The live kidney slice model is a valid complementary technique for investigating vasa recta function in situ and the role of pericytes as regulators of vasa recta diameter. This technique may also be useful in exploring the role of tubulovascular crosstalk in regulation of medullary blood flow
Light drinking in pregnancy, a risk for behavioural problems and cognitive deficits at 3 years of age?
Background
The objective of this study was to determine whether there was an association between mothers’ light drinking during pregnancy and risk of behavioural problems, and cognitive deficits in their children at age 3 years.
Methods
Data from the first two sweeps of the nationally representative prospective UK Millennium Cohort study were used. Drinking patterns during pregnancy and behavioural and cognitive outcomes were assessed during interviews and home visits. Behavioural problems were indicated by scores falling above defined clinically 15 relevant cut-offs on the parent-report version of the Strengths and
Difficulties Questionnaire (SDQ). Cognitive ability was assessed using the naming vocabulary subscale from the British Ability Scale (BAS) and the Bracken School Readiness Assessment (BSRA).
Results
There was a J-shaped relationship between mothers drinking
20 during pregnancy and the likelihood of high scores (above the cut-off) on the total difficulties scale of the SDQ and the conduct problems, hyperactivity and emotional symptom SDQ subscales. Children born to light drinkers were less likely to score above the cut-offs compared with children of abstinent mothers. Children 25 born to heavy drinkers were more likely to score above the cut-offs
compared with children of abstinent mothers. Boys born to mothers who had up to 1–2 drinks per week or per occasion were less likely to have conduct problems (OR 0.59, 95% CI 0.45–0.77) and hyperactivity (OR 0.71, 95% CI 0.54–0.94). These effects remained 30 in fully adjusted models. Girls were less likely to have emotional symptoms (OR 0.72, 95% CI 0.51–1.01) and peer problems (OR 0.68, 95% CI 0.52–0.92) compared with those born to abstainers. These effects were attenuated in fully adjusted models. Boys born to light drinkers had higher cognitive ability test scores [standard
35 deviations, (95% CI)] BAS 0.15 (0.08–0.23) BSRA 0.24 (0.16–0.32) compared with boys born to abstainers. The difference for BAS was attenuated on adjustment for socio-economic factors, whilst the difference for BSRA remained statistically significant.
Conclusions
Children born to mothers who drank up to 1–2 drinks per week or per occasion during pregnancy were not at increased risk of clinically relevant behavioural difficulties or cognitive deficits compared with children of abstinent mothers. Heavy drinking 5 during pregnancy appears to be associated with behavioural problems and cognitive deficits in offspring at age 3 years whereas light drinking does not
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