Suppression of Implanted MDA-MB 231 Human Breast Cancer Growth in Nude Mice by Dietary Walnut

Walnuts contain components that may slow cancer growth including omega 3 fatty acids, phytosterols, polyphenols, carotenoids, and melatonin. A pilot study was performed to determine whether consumption of walnuts could affect growth of MDA-MB 231 human breast cancers implanted into nude mice. Tumor cells were injected into nude mice that were consuming an AIN-76A diet slightly modified to contain 10% corn oil. After the tumors reached 3 to 5 mm diameter, the diet of one group of mice was changed to include ground walnuts, equivalent to 56 g (2 oz) per day in humans. The tumor growth rate from Day 10, when tumor sizes began to diverge, until the end of the study of the group that consumed walnuts (2.9 ± 1.1 mm3/day; mean ± standard error of the mean) was significantly less (P \u3e 0.05, t-test of the growth rates) than that of the group that did not consume walnuts (14.6 ± 1.3 mm 3 /day). The eicosapentaenoic and docosahexaenoic acid fractions of the livers of the group that consumed walnuts were significantly higher than that of the group that did not consume walnuts. Tumor cell proliferation was decreased, but apoptosis was not altered due to walnut consumption. Further work is merited to investigate applications to cancer in humans

Perancangan Buku Referensi Karakteristik Tata Rias Tari Surabaya dengan Teknik Fotografi sebagai Sarana Informasi Masyarakat Surabaya

The Great Indonesian Dictionary (KBBI) defines a reference book as a guidance, hint source, or referencing source. The designing process of this reference book will elucidate the cosmetic characteristics of Surabaya dance (Tari Surabaya) in which most of the society have less recognition about it. The character in the designing process of this reference book represents the cosmetic characteristics of Surabaya dance that. The cosmetic characteristic of Surabaya dance reference book projected to design the cosmetic characteristic of Surabaya dance reference book as an information medium for Surabaya society. In order to support the book, the research employs photography technique that believes could produce a clear, and high quality image. By the existence of the photography technique, the information about cosmetic characteristic of Surabaya dance could become informative and interesting. The informative and interesting book will amplify the reading interest

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy.

Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy. Despite its promising activity, bryostatin 1 is neither evolved nor optimized for the treatment of human disease. Here we report the design, synthesis, and biological evaluation of several close-in analogs of bryostatin 1. Using a function-oriented synthesis approach, we synthesize a series of bryostatin analogs designed to maintain affinity for bryostatin's target protein kinase C (PKC) while enabling exploration of their divergent biological functions. Our late-stage diversification strategy provides efficient access to a library of bryostatin analogs, which per our design retain affinity for PKC but exhibit variable PKC translocation kinetics. We further demonstrate that select analogs potently increase cell surface expression of CD22, a promising CAR T cell target for the treatment of leukemias, highlighting the clinical potential of bryostatin analogs for enhancing targeted immunotherapies

Sensorized Skin With Biomimetic Tactility Features Based on Artificial Cross-Talk of Bimodal Resistive Sensory Inputs

Tactility in biological organisms is a faculty that relies on a variety of specialized receptors. The bimodal sensorized skin, featured in this study, combines soft resistive composites that attribute the skin with mechano- and thermoreceptive capabilities. Mimicking the position of the different natural receptors in different depths of the skin layers, a multi-layer arrangement of the soft resistive composites is achieved. However, the magnitude of the signal response and the localization ability of the stimulus change with lighter presses of the bimodal skin. Hence, a learning-based approach is employed that can help achieve predictions about the stimulus using 4500 probes. Similar to the cognitive functions in the human brain, the cross-talk of sensory information between the two types of sensory information allows the learning architecture to make more accurate predictions of localization, depth, and temperature of the stimulus contiguously. Localization accuracies of 1.8 mm, depth errors of 0.22 mm, and temperature errors of 8.2 °C using 8 mechanoreceptive and 8 thermoreceptive sensing elements are achieved for the smaller inter-element distances. Combining the bimodal sensing multilayer skins with the neural network learning approach brings the artificial tactile interface one step closer to imitating the sensory capabilities of biological skin

Perancangan Komunikasi Visual Oleh-Oleh Khas Surabaya “Guna Guna Snack” Berbasis Pop Art sebagai Upaya Meningkatkan Brand Awareness

Guna Guna Snack is one of the local food producers in Surabaya. Guna Guna Snack become signature's of Surabaya since early 2012. The problem is, at this time there are many competitors offer the same products as Guna Guna Snack. So, to attract attention and introduce products to consumers requires their visual communication design such as media promotion to communicate a message for introduce product of Guna Guna Snack and to differentiate Guna Guna Snack with the other signature's of Surabaya. The research methodology that is used a qualitative methodology with data collection through observation, interviews, documentation, literature, existing studies, and competitors studies. The result of these research will be made a visual communication design such as media promotion in three categories: Above The Line (ATL), Below The Line (BTL), and Through The Line (TTL). With youthful concept and visual displays based on pop art, hopefully it can be representing the face of Guna Guna Snack. The pop art visual later will be used as a tool for media promotion to deliver the message well so that people will recognize Guna Guna Snack

Perancangan Komunikasi Visual Museum Negeri Mpu Tantular melalui Buku Fotografi sebagai Upaya Menginformasikan Koleksi Unggulan Museum

Museum is one of essential parts regarding tourism industrial especially for historical and cultural tourism. One of the museum that existed in East Java is MuseumNegeri Mpu Tantular that legitimately established at July 25th 1937. This museum owns numerous historical collection. Beside the existed collections, it has special considered collection coming from various zone. However, the collections\u27 great quantity frequently makes the visitor don\u27t pay much attention to the special considered collections. According to the aforementioned statement, visual communication through photography book which explains the distinctive collections is clearly needed. This kind of book is expected to clearly and completely inform to the visitor not only about the origin but also the background history from each distinctive collection which is owned by Museum Negeri Mpu Tantular. The method used by utilizing a qualitative research method that starts from collecting data through interviews, observation, documentation, study litelatur, study competitors, until the conclusion. Resulting design photography book with key massage "masterpiece" that has superior meanings or different from the others. Photography books that have been designed to have a visual element that is able to inform the State Museum Negeri Mpu Tantular

Usefulness of standard plasma coagulation tests in the management of perioperative coagulopathic bleeding: is there any evidence?

Standard laboratory coagulation tests (SLTs) such as prothrombin time/international normalized ratio or partial thromboplastin time are frequently used to assess coagulopathy and to guide haemostatic interventions. However, this has been challenged by numerous reports, including the current European guidelines for perioperative bleeding management, which question the utility and reliability of SLTs in this setting. Furthermore, the arbitrary definition of coagulopathy (i.e. SLTs are prolonged by more than 1.5-fold) has been questioned. The present study aims to review the evidence for the usefulness of SLTs to assess coagulopathy and to guide bleeding management in the perioperative and massive bleeding setting. Medline was searched for investigations using results of SLTs as a means to determine coagulopathy or to guide bleeding management, and the outcomes (i.e. blood loss, transfusion requirements, mortality) were reported. A total of 11 guidelines for management of massive bleeding or perioperative bleeding and 64 studies investigating the usefulness of SLTs in this setting were identified and were included for final data synthesis. Referenced evidence for the usefulness of SLTs was found in only three prospective trials, investigating a total of 108 patients (whereby microvascular bleeding was a rare finding). Furthermore, no data from randomized controlled trials support the use of SLTs. In contrast, numerous investigations have challenged the reliability of SLTs to assess coagulopathy or guide bleeding management. There is actually no sound evidence from well-designed studies that confirm the usefulness of SLTs for diagnosis of coagulopathy or to guide haemostatic therap

A Bright Solitonic Matter-Wave Interferometer

We present the first realisation of a solitonic atom interferometer. A Bose-Einstein condensate of $1\times10^4$ atoms of rubidium-85 is loaded into a horizontal optical waveguide. Through the use of a Feshbach resonance, the $s$-wave scattering length of the $^{85}$Rb atoms is tuned to a small negative value. This attractive atomic interaction then balances the inherent matter-wave dispersion, creating a bright solitonic matter wave. A Mach-Zehnder interferometer is constructed by driving Bragg transitions with the use of an optical lattice co-linear with the waveguide. Matter wave propagation and interferometric fringe visibility are compared across a range of $s$-wave scattering values including repulsive, attractive and non-interacting values. The solitonic matter wave is found to significantly increase fringe visibility even compared with a non-interacting cloud.Comment: 6 pages, 4 figure