1,250 research outputs found
Rain-flagging of the Envisat altimeter
As the goals for altimetric measurements become ever more precise, there is concern about the reliable detection and discarding of rain contaminated data. A dual-frequency rain detection technique developed for the Ku- and C-band TOPEX altimeter, is adapted for the Ku- and S-band RA-2 altimeter on Envisat. Of particular concern is the selection of a suitable threshold to minimise the quantity of good data inadvertently discarded
A visible record of eddies in the southern Mozambique Channel
The flows around Madagascar feed into the Agulhas Current, but there have been few hydrographic studies of the flow within the Mozambique Channel. Some cruise and altimetric data point to this being a region of high mesoscale activity, with eddies migrating through the area. Here we show how ocean colour data throw light on the behaviour of eddies in the southern Mozambique Channel
A plankton guide to ocean physics: Colouring in the currents round South Africa and Madagascar
The ocean colour sensor SeaWiFS, launched in August 1997, has been a great boon to those researching large-scale oceanic biological productivity. The sensor can detect variations in the colour of the water due to the presence of chlorophyll in phytoplankton, which essentially changes the water colour from blue to green. SeaWiFS has provided measurements of chlorophyll concentration over nearly all the worldâs oceans, and because of their association with fronts, eddies and regions of upwelling, these records of phytoplankton abundance reveal much about physical processes occurring within the ocean
Measuring rainfall from above and below the sea surface
Satellites play a major role in the determination of the rainfall at sea. Researchers at Southampton Oceanography Centre (SOC) have been involved in two projects addressing this task. First they have been instrumental in developing techniques to retrieve rain rate information from the 10+ years of dual-frequency altimeter data. The TOPEX radar measures rainfall via the attenuation it causes, producing a climatology that is independent of those derived from passive microwave (PM) and infrared (IR) sensors. Because TOPEX is an active microwave sensor, it can have a much smaller footprint than PM sensors. Therefore it can be used to estimate the size of rain cells, showing that the ITCZ and mid-latitude storm tracks are characterized by larger rain systems than elsewhere. TOPEXâs simultaneous recording of wind and wave data reveal that, for mid-latitude systems, rain is most likely in association with developing seas.All satellite-based datasets require validation, and SOC's work on the development and testing of acoustic rain gauges is the second aspect of this paper. By listening at a range of frequencies, an underwater hydrophone may distinguish the spectra of wind, rain, shipping etc., and estimate the wind speed or rain rate according to the magnitude of the signals. All our campaigns have shown a good acoustic response to changes in wind speed. However the quantitative inversion for recent trials has given values that are too high, possibly because of significant acoustic reflection from the sea bottom. The changes in spectral slope often agree with other observations of rain, although validation experiments in coastal regions are hampered by the extraneous sources present. Acoustic rain gauges would eventually see service not only for routine satellite validation, but also for real-time monitoring of locations of interest
234 EXPECTATIONS REGARDING KNEE OSTEOARTHRITIS MANAGEMENT: VIEWS FROM PATIENTS AND PRACTITIONERS. A QUALITATIVE INTERVIEW STUDY
Graphene microwave transistors on sapphire substrates
We have developed metal-oxide graphene field-effect transistors (MOGFETs) on
sapphire substrates working at microwave frequencies. For monolayers, we obtain
a transit frequency up to ~ 80 GHz for a gate length of 200 nm, and a power
gain maximum frequency of about ~ 3 GHz for this specific sample. Given the
strongly reduced charge noise for nanostructures on sapphire, the high
stability and high performance of this material at low temperature, our MOGFETs
on sapphire are well suited for a cryogenic broadband low-noise amplifier
Proton tracking in a high-granularity Digital Tracking Calorimeter for proton CT purposes
Radiation therapy with protons as of today utilizes information from x-ray CT
in order to estimate the proton stopping power of the traversed tissue in a
patient. The conversion from x-ray attenuation to proton stopping power in
tissue introduces range uncertainties of the order of 2-3% of the range,
uncertainties that are contributing to an increase of the necessary planning
margins added to the target volume in a patient. Imaging methods and
modalities, such as Dual Energy CT and proton CT, have come into consideration
in the pursuit of obtaining an as good as possible estimate of the proton
stopping power. In this study, a Digital Tracking Calorimeter is benchmarked
for proof-of-concept for proton CT purposes. The Digital Tracking Calorimeteris
applied for reconstruction of the tracks and energies of individual high energy
protons. The presented prototype forms the basis for a proton CT system using a
single technology for tracking and calorimetry. This advantage simplifies the
setup and reduces the cost of a proton CT system assembly, and it is a unique
feature of the Digital Tracking Calorimeter. Data from the AGORFIRM beamline at
KVI-CART in Groningen in the Netherlands and Monte Carlo simulation results are
used to in order to develop a tracking algorithm for the estimation of the
residual ranges of a high number of concurrent proton tracks. The range of the
individual protons can at present be estimated with a resolution of 4%. The
readout system for this prototype is able to handle an effective proton
frequency of 1 MHz by using 500 concurrent proton tracks in each readout frame,
which is at the high end range of present similar prototypes. A future further
optimized prototype will enable a high-speed and more accurate determination of
the ranges of individual protons in a therapeutic beam.Comment: 21 pages, 8 figure
Retreatment with anti-EGFR based therapies in metastatic colorectal cancer: impact of intervening time interval and prior anti-EGFR response.
BackgroundThis retrospective study aims to investigate the activity of retreatment with anti-EGFR-based therapies in order to explore the concept of clonal evolution by evaluating the impact of prior activity and intervening time interval.MethodsEighty-nine KRAS exon 2-wild-type metastatic colorectal patients were retreated on phase I/II clinical trials containing anti-EGFR therapies after progressing on prior cetuximab or panitumumab. Response on prior anti-EGFR therapy was defined retrospectively per physician-records as response or stable disease â„6 months. Multivariable statistical methods included a multiple logistic regression model for response, and Cox proportional hazards model for progression-free survival.ResultsRetreatment anti-EGFR agents were cetuximab (nâ=â76) or cetuximab plus erlotinib (nâ=â13). The median interval time between prior and retreatment regimens was 4.57 months (range: 0.46-58.7). Patients who responded to the prior cetuximab or panitumumab were more likely to obtain clinical benefit to the retreatment compared to the non-responders in both univariate (pâ=â0.007) and multivariate analyses (OR: 3.38, 95 % CI: 1.27, 9.31, pâ=â0.019). The clinical benefit rate on retreatment also showed a marginally significant association with interval time between the two anti-EGFR based therapies (pâ=â0.053). Median progression-free survival on retreatment was increased in prior responders (4.9 months, 95 % CI: 3.6, 6.2) compared to prior non-responders (2.5 months, 95 % CI, 1.58, 3.42) in univariate (pâ=â0.064) and multivariate analysis (HR: 0.70, 95 % CI: 0.43-1.15, pâ=â0.156).ConclusionOur data lends support to the concept of clonal evolution, though the clinical impact appears less robust than previously reported. Further work to determine which patients benefit from retreatment post progression is needed
Photocurrent measurements of supercollision cooling in graphene
The cooling of hot electrons in graphene is the critical process underlying
the operation of exciting new graphene-based optoelectronic and plasmonic
devices, but the nature of this cooling is controversial. We extract the hot
electron cooling rate near the Fermi level by using graphene as novel
photothermal thermometer that measures the electron temperature () as it
cools dynamically. We find the photocurrent generated from graphene
junctions is well described by the energy dissipation rate , where the heat capacity is and is the
base lattice temperature. These results are in disagreement with predictions of
electron-phonon emission in a disorder-free graphene system, but in excellent
quantitative agreement with recent predictions of a disorder-enhanced
supercollision (SC) cooling mechanism. We find that the SC model provides a
complete and unified picture of energy loss near the Fermi level over the wide
range of electronic (15 to 3000 K) and lattice (10 to 295 K) temperatures
investigated.Comment: 7pages, 5 figure
Extending ballistic graphene FET lumped element models to diffusive devices
In this work, a modified, lumped element graphene field effect device model
is presented. The model is based on the "Top-of-the-barrier" approach which is
usually valid only for ballistic graphene nanotransistors. Proper modifications
are introduced to extend the model's validity so that it accurately describes
both ballistic and diffusive graphene devices. The model is compared to data
already presented in the literature. It is shown that a good agreement is
obtained for both nano-sized and large area graphene based channels. Accurate
prediction of drain current and transconductance for both cases is obtained
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