Optimal densities of packings consisting of highly unequal objects

Let $\Delta$ be the optimal packing density of $\mathbb R^n$ by unit balls. We show the optimal packing density using two sizes of balls approaches $\Delta + (1 - \Delta) \Delta$ as the ratio of the radii tends to infinity. More generally, if $B$ is a body and $D$ is a finite set of bodies, then the optimal density $\Delta_{\{rB\} \cup D}$ of packings consisting of congruent copies of the bodies from $\{rB\} \cup D$ converges to $\Delta_D + (1 - \Delta_D) \Delta_{\{B\}}$ as $r$ tends to zero

Moment methods in energy minimization: New bounds for Riesz minimal energy problems

We use moment methods to construct a converging hierarchy of optimization problems to lower bound the ground state energy of interacting particle systems. We approximate the infinite dimensional optimization problems in this hierarchy by block diagonal semidefinite programs. For this we develop the necessary harmonic analysis for spaces consisting of subsets of another space, and we develop symmetric sum-of-squares techniques. We compute the second step of our hierarchy for Riesz $s$-energy problems with five particles on the $2$-dimensional unit sphere, where the $s=1$ case known as the Thomson problem. This yields new sharp bounds (up to high precision) and suggests the second step of our hierarchy may be sharp throughout a phase transition and may be universally sharp for $5$-particles on $S^2$. This is the first time a $4$-point bound has been computed for a continuous problem

Lower bounds on matrix factorization ranks via noncommutative polynomial optimization

We use techniques from (tracial noncommutative) polynomial optimization to formulate hierarchies of semidefinite programming lower bounds on matrix factorization ranks. In particular, we consider the nonnegative rank, the completely positive rank, and their symmetric analogues: the positive semidefinite rank and the completely positive semidefinite rank. We study the convergence properties of our hierarchies, compare them extensively to known lower bounds, and provide some (numerical) examples

A platform independent communication library for distributed computing

We present MPWide, a platform independent communication library for performing message passing between supercomputers. Our library couples several local MPI applications through a long distance network using, for example, optical links. The implementation is deliberately kept light-weight, platform independent and the library can be installed and used without administrative privileges. The only requirements are a C++ compiler and at least one open port to a wide area network on each site. In this paper we present the library, describe the user interface, present performance tests and apply MPWide in a large scale cosmological N-body simulation on a network of two computers, one in Amsterdam and the other in Tokyo

Semiquantitative interpretation of anticardiolipin and antiβ2glycoprotein I antibodies measured with various analytical platforms: communication from the ISTH SSC subcommittee on Lupus Anticoagulant/Antiphospholipid antibodies

Background Antiβ2glycoprotein I (aβ2GPI) and anticardiolipin (aCL) IgG/IgM show differences in positive/negative agreement and titers between solid phase platforms. Method specific semiquantitative categorization of titers could improve and harmonize the interpretation across platforms. Aim To evaluate the traditionally 40/80 units thresholds used for aCL and aβ2GPI for categorization into moderate/high positivity with different analytical systems, and to compare with alternative thresholds. Material and methods aCL and aβ2GPI thresholds were calculated for two automated systems (chemiluminescent immunoassay (CLIA) and multiplex flow immunoassay (MFI)) by ROC-curve analysis on 1108 patient samples, including patients with and without APS, and confirmed on a second population (n=279). Alternatively, regression analysis on diluted standard material was applied to identify thresholds. Thresholds were compared to 40/80 threshold measured by an enzyme linked immunosorbent assay (ELISA). Additionally, likelihood ratios (LR) were calculated. Results Threshold levels of 40/80 units show poor agreement between ELISA and automated platforms for classification into low/moderate/high positivity, especially for aCL/aβ2GPI IgG. Agreement for semiquantitative interpretation of aPL IgG between ELISA and CLIA/MFI improves with alternative thresholds. LR for aPL IgG increase for thrombotic and obstetric APS based on 40/80 thresholds for ELISA and adapted thresholds for the other systems, but not for IgM. Conclusion Use of 40/80 units as medium/high thresholds is acceptable for aCL/aβ2GPI IgG ELISA, but not for CLIA and MFI. Alternative semiquantitative thresholds for non-ELISA platforms can be determined by a clinical approach or by using monoclonal antibodies. Semiquantitative reporting of aPL IgM has less impact on increasing probability for APS