Investigation if implantable multichannel biotelemetry systems Semiannual report, Sep. 1967 - Feb. 1968

Operation and maintenance of multichannel, physiologically implantable telemetering systems for biological measurement

Pengaruh Perbedaan Waktu Pelepasan Water Jacket dalam Proses Ekuilibrasi terhadap Kualitas Semen Beku Sapi Jawa pada Tahap Before Freezing dan Post Thawing

This experiment was conducted to investigate effect of different water jacket release time on frozen semen quality with two step methods. The semen was collected from four heads Java cattle, extended with skim-egg yolk extender. The extended semen packed with water jacket then release with different time (treatments) T0 (35 minutes), T1 (10 minutes) and T2 (60 minutes) until all equilibration process was finish. Data analysis preparing with normality and homogenity testing, when the data was normal and homogeneous will be followed by analysis of variance (ANOVA). The result showed average of semen quality before freezing T0; T1 and T2 for pH 6,27; 6,27 and 6,43; motility (%) 40,83; 36,67 and 32,50; live sperm percentage (%) 29,68; 33,97 and 22,20; sperm abnormality (%) 20,82; 13,26 and 14,16 respectively. Average of post thawing T0; T1 and T2 for pH 6,27; 6,27 and 6,27; motility (%) 5; 2,92 and 0,42; live sperm percentage (%) 11,21; 12,90 and 19,24; sperm abnormality (%) 22,11; 19,26 and 22,82 respectively. Statistical analysis showed the different water jacket release time did not significantly different (P>0,05) to quality semen of Java bulls at before freezing or post thawing observation

System design and fabrication technique for multi-channel, physiologically implantable, telemetering systems for biological measurements Semiannual report, Sep. 1968 - Feb. 1969

Ring oscillator and strain gage transmitter development for multichannel biotelemetry syste

Animal research is saving lives, but funding is needed to improve welfare: Submission to the New South Wales parliamentary inquiry

Many kinds of animal research are occurring in New South Wales (NSW), with biomedical research among the most prominent. As behavioural neuroscientists, we study the neural mechanisms of motivation and cognition in rodents, which is important for developing new treatments for a range of psychological disorders, such as substance use disorder, as well as neurodegenerative diseases such as Alzheimer’s. The welfare and wellbeing of the animals we study is of critical importance, not only to ensure the quality of our data but to our sense of morality as compassionate human beings. Biomedical animal research is highly regulated and the pharmacological and biological tools we use pose negligible risks to the public. Meanwhile, our research brings enormous benefits to NSW by building expertise and supporting biotechnology companies. Although research on complex behaviours cannot be replaced by non-animal procedures, we believe that there is much scope for refinement and improvement in animal welfare in NSW. For example, investing in a local breeding facility to produce animals used in NSW research projects would significantly reduce the stress associated with importing animals from interstate or overseas. Additionally, standard animal housing could be improved through targeted and ongoing investment to refit animal facilities and support additional caretaker and veterinary staff to provide higher degrees of welfare

Solid State Electronics Laboratory Semiannual report, Feb. - Sep. 1969

Design and performance of miniaturized portable heart rate and electrocardiographic monitoring system for prolonged space flight

An Approach Based on κ-Kӧhler Theory for Calculating CCN Activation Curves that Considers the Dry Particle Size Distribution and Morphology

International audienc

The GOA database in 2009—an integrated Gene Ontology Annotation resource

The Gene Ontology Annotation (GOA) project at the EBI (http://www.ebi.ac.uk/goa) provides high-quality electronic and manual associations (annotations) of Gene Ontology (GO) terms to UniProt Knowledgebase (UniProtKB) entries. Annotations created by the project are collated with annotations from external databases to provide an extensive, publicly available GO annotation resource. Currently covering over 160 000 taxa, with greater than 32 million annotations, GOA remains the largest and most comprehensive open-source contributor to the GO Consortium (GOC) project. Over the last five years, the group has augmented the number and coverage of their electronic pipelines and a number of new manual annotation projects and collaborations now further enhance this resource. A range of files facilitate the download of annotations for particular species, and GO term information and associated annotations can also be viewed and downloaded from the newly developed GOA QuickGO tool (http://www.ebi.ac.uk/QuickGO), which allows users to precisely tailor their annotation set

<i>TP53</i> copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as ’Peto’s Paradox’. Here, we show that the elephant genome encodes 20 copies of the tumor suppressor gene TP53 and that the increase in TP53 copy number occurred coincident with the evolution of large body sizes, the evolution of extreme sensitivity to genotoxic stress, and a hyperactive TP53 signaling pathway in the elephant (Proboscidean) lineage. Furthermore, we show that several of the TP53 retrogenes (TP53RTGs) are transcribed and likely translated. While TP53RTGs do not appear to directly function as transcription factors, they do contribute to the enhanced sensitivity of elephant cells to DNA damage and the induction of apoptosis by regulating activity of the TP53 signaling pathway. These results suggest that an increase in the copy number of TP53 may have played a direct role in the evolution of very large body sizes and the resolution of Peto’s paradox in Proboscideans