620 research outputs found
Breast Ultrasound Following a Positive Clinical Breast Examination: Does It Have a Role in Low- and Middle-Income Countries?
Purpose: Breast cancer is the most common cancer among women worldwide, with an estimated 1.7 million new cases occurring in 2012. The majority of cases and deaths occur in low- and middle-income countries (LMICs), where population-based mammography screening is not available and countries must rely on clinical breast examination (CBE). Since ultrasound has the potential to reduce unnecessary biopsies by triaging women with palpable or focal breast findings at CBE, we searched for evidence in the literature on the effectiveness of ultrasound in detecting potential breast cancer following positive CBE findings.
Methods: We reviewed the literature from 2000 to 2014 for evidence on the performance of breast ultrasound, in the absence of mammography, used to evaluate women after a positive CBE. From the studies meeting our inclusion/exclusion criteria for our analysis, we extracted data on the study design, location, ultrasound transducer parameters, patient age, method for determining positive and negative cases, and number of malignancies detected/total number of women studied.
Results: We found 15 studies matching our inclusion/exclusion criteria, 9 from high-income countries and 6 from LMICs. Despite considerable variability in study design and patient populations, breast ultrasound consistently showed high sensitivity (median = 94 percent) and specificity (median = 80 percent) for detecting breast cancer and identifying normal and benign findings not requiring a biopsy. Clear patterns related to transducer frequency or income level were not discernible given the variations in patient populations and final diagnostic determinations.
Conclusion: Our systematic review suggests that breast ultrasound following a positive CBE may be a powerful diagnostic test to determine those who do or do not need biopsy. We encourage further research in breast ultrasound use after a positive CBE in LMICs to assess the accuracy of ultrasound in these settings and the feasibility of widespread implementation
Linked Data Publication of Live Music Archives and Analyses
date-added: 2017-12-22 15:39:21 +0000 date-modified: 2017-12-22 15:53:18 +0000 keywords: Linked Data, Semantic Audio, Semantic Web, live music archive local-url: https://link.springer.com/chapter/10.1007/978-3-319-68204-4_3 bdsk-url-1: https://iswc2017.semanticweb.org/wp-content/uploads/papers/MainProceedings/221.pdf bdsk-url-2: https://dx.doi.org/10.1007/978-3-319-68204-4_3date-added: 2017-12-22 15:39:21 +0000 date-modified: 2017-12-22 15:53:18 +0000 keywords: Linked Data, Semantic Audio, Semantic Web, live music archive local-url: https://link.springer.com/chapter/10.1007/978-3-319-68204-4_3 bdsk-url-1: https://iswc2017.semanticweb.org/wp-content/uploads/papers/MainProceedings/221.pdf bdsk-url-2: https://dx.doi.org/10.1007/978-3-319-68204-4_3We describe the publication of a linked data set exposing metadata from the Internet Archive Live Music Archive along with detailed feature analysis data of the audio files contained in the archive. The collection is linked to existing musical and geographical resources allowing for the extraction of useful or nteresting subsets of data using additional metadata. The collection is published using a âlayeredâ approach, aggregating the original information with links and specialised analyses, and forms a valuable resource for those investigating or developing audio analysis tools and workflows
Evidence of re-osseointegration after electrolytic cleaning and regenerative therapy of peri-implantitis in humans: a case report with four implants.
OBJECTIVE
To evaluate re-osseointegration after electrolytic cleaning and regenerative therapy of dental implants with peri-implantitis in humans.
MATERIAL AND METHODS
Four dental implants that developed peri-implantitis underwent electrolytic cleaning followed by regenerative therapy with guided bone regeneration. All four implants developed recurrent peri-implantitis and were therefore explanted 6 to 13Â months later. Radiographic bone level, probing depth, and bleeding on probing were determined at the time of surgery, 6Â months later, and before implant retrieval. The peri-implant tissues were histologically and histomorphometrically analyzed.
RESULTS
All four implants demonstrated radiographic and histological bone gain, reduced probing depth, and bleeding on probing. Radiographic bone gain was 5.8 mm mesially and 4.8 mm distally for implant #1, 3.3 mm and 2.3 mm for implant #2, 3.1 mm and 0.5 mm for implant #3, and 3.5 mm and 2.8 mm for implant #4. The histometric mean and maximum vertical bone gain for implant #1 to #4 was 1.65 mm and 2.54 mm, 3.04 mm and 3.47 mm, 0.43 mm and 1.27 mm, and 4.16 mm and 5.22 mm, respectively. The percentage of re-osseointegration for implant #1 to #4 was 21.0%, 36.9%, 5.7%, and 39.0%, respectively. In one implant, the newly formed bone was deposited directly onto calculus on the implant surface.
CONCLUSIONS
We found that (1) re-osseointegration is possible on a formerly contaminated implant surface and (2) the electrolytic cleaning process seems to be effective enough at sites with calculus residues.
CLINICAL RELEVANCE
Since re-osseointegration can be achieved by electrolytic cleaning, this decontamination technique may be considered as a future treatment concept
Ethnic In-Group Favoritism Among Minority and Majority Groups: Testing the Self-Esteem Hypothesis Among Preadolescents
The self-esteem hypothesis in intergroup relations, as proposed by social identity
theory (SIT), states that successful intergroup discrimination enhances momentary
collective self-esteem. This hypothesis is a source of continuing controversy. Furthermore,
although SIT is increasingly used to account for childrenâs group attitudes,
few studies have examined the hypothesis among children. In addition, the
hypothesisâs generality makes it important to study among children from different
ethnic groups. The present study, conducted among Dutch and Turkish preadolescents,
examined momentary collective self-feelings as a consequence of ethnic group
evaluations. The results tended to support the self-esteem hypothesis. In-group
favoritism was found to have a self-enhancing effect among participants high in
ethnic identification. This result was found for ethnic majority (Dutch) and minority
(Turkish) participants.
Chiral extrapolation of lattice moments of proton quark distributions
We present the resolution of a long-standing discrepancy between the moments
of parton distributions calculated from lattice QCD and their experimental
values. We propose a simple extrapolation formula for the moments of the
nonsinglet quark distribution u-d, as a function of quark mass, which embodies
the general constraints imposed by the chiral symmetry of QCD. The inclusion of
the leading nonanalytic behavior leads to an excellent description of both the
lattice data and the experimental values of the moments.Comment: 9 pages, 1 figure, to appear in Physical Review Letter
Multimodule Web-Based COVID-19 Anxiety and Stress Resilience Training (COAST): Single-Cohort Feasibility Study With First Responders
BACKGROUND
Since the emergence of COVID-19, health care workers and first responders have been at a high risk for mental health symptoms owing to their exposure to the virus and increased work stress during the pandemic. Although interventions exist to address mental health issues following exposure to disasters, emergencies, and humanitarian crises, considerably less is known about web-based unguided interventions to help mitigate the negative impacts of such events. Additionally, in contexts in which emergencies reduce access to in-person care, remote forms of support are critical, yet there are limited studies on the use of such interventions. Evidence-based, easy-to-use, scalable interventions are direly needed for this population.
OBJECTIVE
This study aimed to develop and test the feasibility of an unguided electronic mental health program, COVID-19 Anxiety and Stress Resilience Training (COAST), tailored to first responders and health care personnel, based on scientific evidence and empirically based techniques.
METHODS
We developed COVID-19-specific training modules focusing on several domains that are previously reported as key to resilience and stress recovery: self-efficacy, mindfulness, sleep quality, and positive thinking. The program was made available to 702 first responders between May and August 2020, during the COVID-19 pandemic. Sociodemographic, work-, and COVID-19-related information was collected, and psychometric questionnaires were completed. We examined user acceptance and user activity, including module choice and participant feedback.
RESULTS
In total, 52 of 702 (7%) first responders to whom we reached out used the program at least once. COAST use was independent of age, sex, or baseline levels of self-efficacy, mindful awareness, sleep quality, and positive thinking (for all, P>.39). First responders who had tested positive and those who had been quarantined were more likely to engage in the program. A click count analysis per module showed that participants used the self-efficacy and mindfulness modules most often, with 382 and 122 clicks, respectively, over 15 weeks. Overall, first responders expressed satisfaction with the program.
CONCLUSIONS
Engagement of first responders in the multimodule web-based COAST program was feasible and the first responder cohort expressed overall satisfaction with the program. Those in more difficult circumstances, including those in quarantine and those who tested positive, may be more likely to engage in such programs. Further controlled studies could pave the way for efficacy studies and the development of additional modules, including just-in-time interventions or blended interventions combining individual use of an unguided self-help intervention, such as COAST, with subsequent individual psychotherapy for those who continue to experience stress and psychological symptoms
A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels
In this study, we designed a novel biomaterial ink platform based on hydrophilic poly(2-ethyl-2-oxazine) (PEtOzi) specifically for melt electrowriting (MEW). This material crosslinks spontaneously after processing via dynamic DielsâAlder click chemistry. These direct-written microperiodic structures rapidly swell in water to yield thermoreversible hydrogels. These hydrogels are robust enough for repeated aspiration and ejection through a cannula without structural damage, despite their high water content of 84%. Moreover, the scaffolds retain functional groups for modification using click chemistry and therefore can be readily functionalized as demonstrated using fluorophores and peptides to facilitate visualization and cell attachment. The PEtOzi hydrogel developed here is compatible with confocal imaging and staining protocols for cells. In summary, an advanced material platform based on PEtOzi is reported that is compatible with MEW and results in functionalizable chemically crosslinked microperiodic hydrogels.Peer reviewe
Building Prototypes Aggregating Musicological Datasets on the Semantic Web
Semantic Web technologies such as RDF, OWL,
and SPARQL can be successfully used to bridge complementary
musicological information. In this paper, we describe,
compare, and evaluate the datasets and workflows
used to create two such aggregator projects: In Collaboration
with In Concert, and JazzCats, both of which bring
together a cluster of smaller projects containing concert
and performance metadata
Spin-Dependent Twist-Four Matrix Elements from g_1 Data in the Resonance Region
Matrix elements of spin-dependent twist-four operators are extracted from
recent data on the spin-dependent g_1 structure function of the proton and
deuteron in the resonance region. We emphasize the need to include the elastic
contributions to the first moments of the structure functions at Q^2 < 2 GeV^2.
The coefficients of the 1/Q^2 corrections to the Ellis-Jaffe sum rules are
found to be 0.04 \pm 0.02 and 0.03 \pm 0.04 GeV^2 for the proton and neutron,
respectively.Comment: 10 pages REVTeX, 4 figure
Nonperturbative versus perturbative effects in generalized parton distributions
Generalized parton distributions (GPDs) are studied at the hadronic
(nonperturbative) scale within different assumptions based on a relativistic
constituent quark model. In particular, by means of a meson-cloud model we
investigate the role of nonperturbative antiquark degrees of freedom and the
valence quark contribution. A QCD evolution of the obtained GPDs is used to add
perturbative effects and to investigate the GPDs' sensitivity to the
nonperturbative ingredients of the calculation at larger (experimental) scale.Comment: 17 pages, 10 figures; submitted to Phys. Rev.
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