Estratigrafía y petrología del subsuelo recuaternario del sector sw de la depresión de Barcelona (cadenas costeras catalanas, ne de Iberia)

[email protected] numerosas obras de Ingeniería Civil que se han realizado en los últimos años en la depresión de Barcelona (ampliación del aeropuerto, ampliación del metro y AVE fundamentalmente) han permitido recabar mucha información sobre el subsuelo de esta área. En este trabajo se caracterizan las distintas unidades de subsuelo precuaternarias que aparecen en los numerosos sondeos realizados recientemente en la zona SW de la depresión de Barcelona. Se ha identificado un sustrato triásico formado por areniscas del Buntsandstein y dos unidades de edad Miocena, una basal de carácter continental y otra superior depositada en un ambiente marino. Todas estas unidades fueron fracturadas debido a una tectónica extensiva y, posteriormente, fueron fosilizadas en primer lugar por los sedimentos del Plioceno, que recubren la superficie de erosión messiniense, y finalmente, por el Cuaternario. El análisis de las distintas unidades permite obtener datos sobre la evolución paleogeográfica y tectónica de la depresión de Barcelona durante el Mioceno y el Plioceno.Current building of civil Engineering infrastructures in the Barcelona plain and Llobregat delta (mainly metro and airport extension and high speed train) is providing new geological subsurface data to build better geologic models and understand the basin evolution. This work focuses on the pre-Quaternary units observed in cores. Based on petrographic analyses combined when it was possible with paleontological studies, we identified the lower Triassic Buntsandstein sandstone facies and Miocene continental and marine facies which appear compartmentalized due to extensive deformation. After this extensive episode, Pliocene and Quaternary sediments, which were deposited after the development of successive erosive surfaces, overlay the Triassic and Miocene units. The identification of these units enabled one to improve the interpretation of the tectonic and paleogeographic evolution of the Barcelona plain

Estratigrafía y petrología del subsuelo precuaternario del sector SW de la depresión de Barcelona (Cadenas Costeras Catalanas, NE de Iberia)

Las numerosas obras de Ingeniería Civil que se han realizado en los últimos años en la depresión de Barcelona (ampliación del aeropuerto, ampliación del metro y AVE fundamentalmente) han permitido recabar mucha información sobre el subsuelo de esta área. En este trabajo se caracterizan las distintas unidades de subsuelo precuaternarias que aparecen en los numerosos sondeos realizados recientemente en la zona SW de la depresión de Barcelona. Se ha identificado un sustrato triásico formado por areniscas del Buntsandstein y dos unidades de edad Miocena, una basal de carácter continental y otra superior depositada en un ambiente marino. Todas estas unidades fueron fracturadas debido a una tectónica extensiva y, posteriormente, fueron fosilizadas en primer lugar por los sedimentos del Plioceno, que recubren la superficie de erosión messiniense, y finalmente, por el Cuaternario. El análisis de las distintas unidades permite obtener datos sobre la evolución paleogeográfica y tectónica de la depresión de Barcelona durante el Mioceno y el Plioceno.Peer ReviewedPostprint (published version

redesign and manufacturing of a metal towing hook via laser additive manufacturing with powder bed

Abstract An approach to redesign and manufacture a metal towing hook via Selective Laser Melting is discussed. Some reference criteria and general guidelines are considered step-by-step to concurrently address lightening, manufacturability and job planning. Grounds are given for the application of Additive Manufacturing for complex components to the purpose of material saving and increased safety factor

Sugar-protein connectivity impacts on the immunogenicity of site-selective salmonella O-antigen glycoconjugate vaccines

A series of glycoconjugates with defined connectivity were synthesized to investigate the impact of coupling Salmonella typhimurium O-antigen to different amino acids of CRM197 protein carrier. In particular, two novel methods for site-selective glycan conjugation were developed to obtain conjugates with single attachment site on the protein, based on chemical modification of a disulfide bond and pH-controlled transglutaminase-catalyzed modification of lysine, respectively. Importantly, conjugation at the C186-201 bond resulted in significantly higher anti O-antigen bactericidal antibody titers than coupling to K37/39, and in comparable titers to conjugates bearing a larger number of saccharides. This study demonstrates that the conjugation site plays a role in determining the immunogenicity in mice and one single attachment point may be sufficient to induce high levels of bactericidal antibodies

Benchmarking of human Y-chromosomal haplogroup classifiers with whole-genome and whole-exome sequence data

In anthropological, medical, and forensic studies, the nonrecombinant region of the human Y chromosome (NRY) enables accurate reconstruction of pedigree relationships and retrieval of ancestral information. Using high-throughput sequencing (HTS) data, we present a benchmarking analysis of command-line tools for NRY haplogroup classification. The evaluation was performed using paired Illumina data from whole-genome sequencing (WGS) and whole-exome sequencing (WES) experiments from 50 unrelated donors. Additionally, as a validation, we also used paired WGS/WES datasets of 54 individuals from the 1000 Genomes Project. Finally, we evaluated the tools on data from third-generation HTS obtained from a subset of donors and one reference sample. Our results show that WES, despite typically offering less genealogical resolution than WGS, is an effective method for determining the NRY haplogroup. Y-LineageTracker and Yleaf showed the highest accuracy for WGS data, classifying precisely 98% and 96% of the samples, respectively. Yleaf outperforms all benchmarked tools in the WES data, classifying approximately 90% of the samples. Yleaf, Y-LineageTracker, and pathPhynder can correctly classify most samples (88%) sequenced with third-generation HTS. As a result, Yleaf provides the best performance for applications that use WGS and WES. Overall, our study offers researchers with a guide that allows them to select the most appropriate tool to analyze the NRY region using both second- and third-generation HTS data

Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients

Purpose. To investigate how pretreatment testosterone levels correlate with progression-free survival, metastasis-free survival, and overall survival in a propensity-adjusted localized prostate cancer population. Methods. Men diagnosed with clinical NCCN-risk stratified very-low, low, intermediate, high, and/or very-high risk prostate cancer who had a baseline total serum testosterone level≥100 ng/dl measured within the 100 days preceding the first definitive therapy were identified from our prospectively gathered institutional database. Cohorts below (100–239 ng/dl), within (240–593 ng/dl), or above (594 + ng/dl) one standard deviation from the mean testosterone level (416 ng/dl) were used for comparison. Progression-free, metastasis-free, and overall survival were evaluated. A separate cohort of men not receiving ADT was used to evaluate testosterone recovery after various treatment modalities (surgery, external beam radiation, brachytherapy, or combined EBRT + Brachy). Results. There was no statistically significant difference between the low, average, and high testosterone cohorts for PFS, MFS, or OS. In men not using ADT, there were no statistically significant changes in testosterone levels 1 year after therapy, regardless of therapy type. Conclusion. In men with serum testosterone levels >=100 ng/dl at diagnosis, baseline testosterone does not impact PFS, MFS, or OS. Recovery of testosterone back to baseline is expected for men undergoing either surgery, external beam or brachytherapy, or combined modality radiation when not using ADT

Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients

Purpose. To investigate how pretreatment testosterone levels correlate with progression-free survival, metastasis-free survival, and overall survival in a propensity-adjusted localized prostate cancer population. Methods. Men diagnosed with clinical NCCN-risk stratified very-low, low, intermediate, high, and/or very-high risk prostate cancer who had a baseline total serum testosterone level≥100 ng/dl measured within the 100 days preceding the first definitive therapy were identified from our prospectively gathered institutional database. Cohorts below (100–239 ng/dl), within (240–593 ng/dl), or above (594 + ng/dl) one standard deviation from the mean testosterone level (416 ng/dl) were used for comparison. Progression-free, metastasis-free, and overall survival were evaluated. A separate cohort of men not receiving ADT was used to evaluate testosterone recovery after various treatment modalities (surgery, external beam radiation, brachytherapy, or combined EBRT + Brachy). Results. There was no statistically significant difference between the low, average, and high testosterone cohorts for PFS, MFS, or OS. In men not using ADT, there were no statistically significant changes in testosterone levels 1 year after therapy, regardless of therapy type. Conclusion. In men with serum testosterone levels &gt;=100 ng/dl at diagnosis, baseline testosterone does not impact PFS, MFS, or OS. Recovery of testosterone back to baseline is expected for men undergoing either surgery, external beam or brachytherapy, or combined modality radiation when not using ADT.</jats:p