Explicit Global Coordinates for Schwarzschild and Reissner-Nordstroem

We construct coordinate systems that cover all of the Reissner-Nordstroem solution with m>|q| and m=|q|, respectively. This is possible by means of elementary analytical functions. The limit of vanishing charge q provides an alternative to Kruskal which, to our mind, is more explicit and simpler. The main tool for finding these global charts is the description of highly symmetrical metrics by two-dimensional actions. Careful gauge fixing yields global representatives of the two-dimensional theory that can be rewritten easily as the corresponding four-dimensional line elements.Comment: 12 pages, 3 Postscript figures, sign error in Eq. (37) and below corrected, references and Note added; to appear in Class. Quantum Gra

O stars effective temperature and HII regions ionization parameter gradients in the Galaxy

Extensive photoionization model grids are computed for single star HII regions using stellar atmosphere models from the WM-basic code. Mid-IR emission line intensities are predicted and diagnostic diagrams of [NeIII]/[NeII] and [SIV]/[SIII] excitation ratio are build, taking into account the metallicities of both the star and the HII region. The diagrams are used in conjunction with galactic HII region observations obtained with the ISO Observatory to determine the effective temperature Teff of the exciting O stars and the mean ionization parameter U. Teff and U are found to increase and decrease, respectively, with the metallicity of the HII region represented by the [Ne/Ne_sol] ratio. No evidence is found for gradients of Teff or U with galactocentric distance Rgal. The observed excitation sequence with Rgal is mainly due to the effect of the metallicity gradient on the spectral ionizing shape, upon which the effect of an increase in Teff with Z is superimposed. We show that not taking properly into account the effect of metallicity on the ionizing shape of the stellar atmosphere would lead to an apparent decrease of Teff with Z and an increase of Teff with Rgal.Comment: Accepted in Ap

FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?

FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell–matrix and cell–cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migration

Empirical logic of finite automata: microstatements versus macrostatements

We compare the two approaches to the empirical logic of automata. The first, called partition logic (logic of microstatements), refers to experiments on individual automata. The second one, the logic of simulation (logic of macrostatements), deals with ensembles of automata.Comment: late

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals.

IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps. Surprisingly, human IFIT1 does not share this antiviral specificity. Here, we resolve this discrepancy by demonstrating that human and mouse IFIT1 have evolved distinct functions using a combination of evolutionary, genetic and virological analyses. First, we show that human IFIT1 and mouse IFIT1 (renamed IFIT1B) are not orthologs, but are paralogs that diverged >100 mya. Second, using a yeast genetic assay, we show that IFIT1 and IFIT1B proteins differ in their ability to be suppressed by a cap 2'O-methyltransferase. Finally, we demonstrate that IFIT1 and IFIT1B have divergent antiviral specificities, including the discovery that only IFIT1 proteins inhibit a virus encoding a cap 2'O-methyltransferase. These functional data, combined with widespread turnover of mammalian IFIT genes, reveal dramatic species-specific differences in IFIT-mediated antiviral repertoires