A comparison of different methods of estimating and testing the especification of rational expectation models with one endogeneus and one exogenus variable.

This article considers the theory of the estimation and testing of a model with one endogenous variable and one exogenous variable, where the structure of the model assumes a simple rational expectations hypothesis for the determination of the endogenous variable. Two methods of estimation are considered, the first the method of Maximum Likelihood, and the second the method of Instrumental Variables. The first is asymptotically efficient, the second may be relatively less asymptotically efficient. The first also has the advantage of suggesting suitable tests for the general form of the rational expectations model.Instrumental variables; Maximum likelihood estimation;

A comparison of different methods of estimating and testing the especification of rational expectation models with one endogeneus and one exogenus variable

This article considers the theory of the estimation and testing of a model with one endogenous variable and one exogenous variable, where the structure of the model assumes a simple rational expectations hypothesis for the determination of the endogenous variable. Two methods of estimation are considered, the first the method of Maximum Likelihood, and the second the method of Instrumental Variables. The first is asymptotically efficient, the second may be relatively less asymptotically efficient. The first also has the advantage of suggesting suitable tests for the general form of the rational expectations model

What Could a Trans Book History Look Like? Toward Trans Codicology

This article draws on critical trans studies and queer archival practice to propose a book historical mode that extends what we know about the premodern trans experience beyond the recovery of individual biographies. Instead of turning to textual sources for the identification of transness, the author looks to Susan Stryker’s call for the “recuperat[ion of] embodied knowing as a formally legitimated basis of knowledge production.” Bibliography, he suggests, makes claims of objectivity that engender a particular reluctance to respond to such calls. But the lived reality of archival research is one of affective embodiment. Affect theory is an area that, as yet, has seen little methodological uptake in bibliographical research. This article lays the ground for a trans book history that takes affective embodied response seriously as a source of trans connection to and through the past. (In the issue section Bibliographic Knowledge(s)

The spectral estimation of simultaneous equation systems with lagged endogenous variables

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The Ghosts of Bindings Past: Micro-Computed X-Ray Tomography for the Study of Bookbinding

This essay describes the results of a new application of micro-computed X-ray tomography (µCT) to conduct nondestructive investigations of the binding structures of premodern books. This application addresses a twofold challenge in the study of historic bindings and their construction. Few premodern books survive in their original bindings. Moreover, until recently, when books were rebound, the original structures were rarely documented, and the remains were usually discarded. Where original bindings do remain in situ, much of their structure is, by design, hidden. Particulars of construction may be surmised; but without destructive disbinding, little can be proven. µCT enables an exploratory, multilinear approach to codicological investigations that makes bindings accessible in the form of tractable volumetric data

Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci

Dogs are an excellent model for human disease. For example, the treatment of canine lymphoma has been predictive of the human response to that treatment. However, an incomplete picture of canine (Canis lupus familiaris) immunoglobulin (IG) and T cell receptor (TR) - or antigen receptor (AR) - gene loci has restricted their utility. This work advances the annotation of the canine AR loci and looks into breed-specific features of the loci. Bioinformatic analysis of unbiased RNA sequence data was used to complete the annotation of the canine AR genes. This annotation was used to query 107 whole genome sequences from 19 breeds and identified over 5,500 alleles across the 550 genes of the seven AR loci: the IG heavy, kappa, and lambda loci; and the TR alpha, beta, gamma, and delta loci. Of note was the discovery that half of the IGK variable (V) genes were located downstream of, and inverted with respect to, the rest of the locus. Analysis of the germline sequences of all the AR V genes identified greater conservation between dog and human than mouse with either. This work brings our understanding of the genetic diversity and expression of AR in dogs to the same completeness as that of mice and men, making it the third species to have all AR loci comprehensively and accurately annotated. The large number of germline sequences serves as a reference for future studies, and has allowed statistically powerful conclusions to be drawn on the pressures that have shaped these loci.This work was supported by funding from the BBSRC and the Wellcome Trust

Health-related welfare prioritisation of canine disorders using electronic health records in primary care practice in the UK

Background: Evidence-based comparison of the disorder-specific welfare burdens of major canine conditions could better inform targeting of stakeholder resources, to maximise improvement of health-related welfare in UK dogs. Population-level disease related welfare impact offers a quantitative, welfare-centred framework for objective disorder prioritisation, but practical applications have been limited to date due to sparse reliable evidence on disorder-specific prevalence, severity and duration across the canine disease spectrum. The VetCompass™ Programme collects de-identified electronic health record data from dogs attending primary-care clinics UK-wide, and is well placed to fill these information gaps. Results: The eight common, breed-related conditions assessed were anal sac disorder, conjunctivitis, dental disease, dermatitis, overweight/obese, lipoma, osteoarthritis and otitis externa. Annual period prevalence estimates (based on confirming 250 cases from total potential cases identified from denominator population of 455, 557 dogs) were highest for dental disorder (9.6%), overweight/obese (5.7%) and anal sac disorder (4.5%). Dental disorder (76% of study year), osteoarthritis (82%), and overweight/obese (70%) had highest annual duration scores. Osteoarthritis (scoring 13/21), otitis externa (11/21) and dermatitis demonstrated (10/21) highest overall severity scores. Dental disorder (2.47/3.00 summative score), osteoarthritis (2.24/3.00) and overweight/obese (1.67/3.00) had highest VetCompass Welfare Impact scores overall. Discussion: Of the eight common, breed-related disorders assessed, dental disorder, osteoarthritis and overweight/obese demonstrated particular welfare impact, based on combinations of high prevalence, duration and severity. Future work could extend this methodology to cover a wider range of disorders. Conclusions: Dental disorders, osteoarthritis and overweight/obese have emerged as priority areas for health-related welfare improvement in the UK dog population. This study demonstrated applicability of a standardised methodology to assess the relative health-related welfare impact across a range of canine disorders using VetCompass clinical data

Early events in immune evasion by the lentivirus maedi-visna occurring within infected lymphoid tissue

Infections caused by lentiviruses, including human immunodeficiency virus, are characterized by slowly progressive disease in the presence of a virus-specific immune response. The earliest events in the virus-host interaction are likely to be important in determining disease establishment and progression, and the kinetics of these early events following lentiviral infection are described here. Lymphatic cannulation in the sheep has been used to monitor both the virus and the immune response in efferent lymph after infection of the node with maedi-visna virus (MVV). Viral replication and dissemination could be detected and consisted of a wave of MVV-infected cells leaving the node around 9 to 18 days postinfection. No cell-free virus was recovered despite the fact that soluble MVV p25 was detected in lymph plasma. The maximum frequency of MVV-infected cells was only 11 in 10(6) but over the first 20 days of infection amounted to greater than 10(4) virus-infected cells leaving the node. There was a profound increase in the output of activated lymphoblast from the lymph nodes of infected sheep, characterized by an increased percentage of CD8+ lymphoblasts. All of the CD8+ lymphoblasts at the peak of the response expressed both major histocompatibility complex class II DR and DQ molecules but not interleukin-2 receptor (CD25). The in vitro proliferative response of efferent lymph cells existing the node after challenge with MVV to both recombinant human interleukin-2 and the mitogen concanavalin A was decreased between days 8 and 16 postinfection, and a specific proliferative response to MVV was not detected until after day 15. Despite the high level of CD8+ lymphoblasts in efferent lymph, direct MVV-specific cytotoxic activity was demonstrated in only one of the five MVV-challenged sheep. MVV-specific antibody responses, including neutralization and MVV p25 immune complexes in efferent lymph, were detectable during the major period of virus dissemination. The relationship of these findings to the evasion of the host's acute immune response by MVV is discussed