Prenatal exposures and exposomics of asthma

This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi

Effect of humic substances extracted from pasture and forested soils on plant metabolism

The biological activity of humic matter extracted from pasture and forested alpine soils, located in a unique climatic area, was investigated with Picea abies seedlings and Zea mays roots. The humic extracts were characterized by 13 C-NMR-spectra and by the amount of indole-3-acetic acid (IAA). Results evidenced that the forest humus, endowed with a higher phenolic C and IAA content, exhibits a better influence on peroxidase activity, esterase and peroxidase polymorphism and redox membrane activit