Subsecond total-body imaging using ultrasensitive positron emission tomography.

A 194-cm-long total-body positron emission tomography/computed tomography (PET/CT) scanner (uEXPLORER), has been constructed to offer a transformative platform for human radiotracer imaging in clinical research and healthcare. Its total-body coverage and exceptional sensitivity provide opportunities for innovative studies of physiology, biochemistry, and pharmacology. The objective of this study is to develop a method to perform ultrahigh (100 ms) temporal resolution dynamic PET imaging by combining advanced dynamic image reconstruction paradigms with the uEXPLORER scanner. We aim to capture the fast dynamics of initial radiotracer distribution, as well as cardiac motion, in the human body. The results show that we can visualize radiotracer transport in the body on timescales of 100 ms and obtain motion-frozen images with superior image quality compared to conventional methods. The proposed method has applications in studying fast tracer dynamics, such as blood flow and the dynamic response to neural modulation, as well as performing real-time motion tracking (e.g., cardiac and respiratory motion, and gross body motion) without any external monitoring device (e.g., electrocardiogram, breathing belt, or optical trackers)

Topological quantum memory interfacing atomic and superconducting qubits

We propose a scheme to manipulate a topological spin qubit which is realized with cold atoms in a one-dimensional optical lattice. In particular, by introducing a quantum opto-electro-mechanical interface, we are able to first transfer a superconducting qubit state to an atomic qubit state and then to store it into the topological spin qubit. In this way, an efficient topological quantum memory could be constructed for the superconducting qubit. Therefore, we can consolidate the advantages of both the noise resistance of the topological qubits and the scalability of the superconducting qubits in this hybrid architecture.Comment: v2: Accepted for publication in Science China-Physics, Mechanics & Astronom

Protective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats

Osteocyte apoptosis is the first reaction to estrogen depletion, thereby stimulating osteoclastic bone resorption resulting in bone loss. We investigated the effects of two different risedronate (RIS) doses (high and low) on osteocyte apoptosis, osteoclast activity and bone loss in ovariectomized rats. Forty rats with ovariectomy (OVX) and sham ovariectomy (SHAM) were divided into 4 groups: 1) SHAM rats treated with saline (SHAM); 2) OVX rats treated with saline (OVX); 3) OVX rats treated with low-dose RIS (OVX-LR, 0.08 μg/kg/day); 4) OVX rats treated with high-dose RIS (OVX-HR, 0.8 μg/kg/day). All animals were sacrificed 90 days after surgery for the examinations of osteocyte apoptosis by caspase-3 staining, osteoclast activity by TRAP staining and bone volume by micro-CT scanning in lumbar vertebral cancellous bone. Both low and high dose RIS significantly reduced caspase-3 positive osteocytes, empty lacunae and TRAP positive osteoclasts in OVX rats. Although the difference in caspase-3 positive osteocytes was not significant between the OVX-LR and OVX-HR groups, numerically these cells were significantly more prevalent in OVX-HR (not OVX-LR) group than in SHAM group. TRAP positive osteoclasts were significantly higher in OVX-LR group than in SHAM or OVX-HR group. There was no significant difference in bone volume among the OVX-LR, OVX-HR and SHAM groups, but lower in OVX group alone. However, significant increase in trabecular thickness only occurred in OVX-LR group. We conclude that both low and high dose RIS significantly inhibit osteocyte apoptosis and osteoclast activity in OVX rats, but the low-dose RIS has weaker effect on osteoclast activity. However, low-dose RIS preserves cancellous bone mass and microarchitecture as well as high-dose RIS after estrogen depletion

Transversity PDFs of the proton from lattice QCD with physical quark masses

We present a lattice QCD calculation of the transversity isovector- and isoscalar-quark parton distribution functions (PDFs) of the proton utilizing a perturbative matching at next-to-leading-order (NLO) accuracy. Additionally, we determine the isovector and isoscalar tensor charges for the proton. In both calculations, the disconnected contributions to the isoscalar matrix elements have been ignored. The calculations are performed using a single ensemble of $N_f = 2 +1$ highly-improved staggered quarks simulated with physical-mass quarks and a lattice spacing of $a = 0.076$ fm. The Wilson-clover action, with physical quark masses and smeared gauge links obtained from one iteration of hypercubic (HYP) smearing, is used in the valence sector. Using the NLO operator product expansion, we extract the lowest four to six Mellin moments and the PDFs from the matrix elements via a neural network. In addition, we calculate the $x$-dependence of the PDFs with hybrid-scheme renormalization and the recently developed leading-renormalon resummation technique, at NLO with the resummation of leading small-$x$ logarithms.Comment: 23 pages, 22 figures, and 2 table

Effects of NaCl treatment on the antioxidant enzymes of oilseed rape (Brassica napus L.) seedlings

The effects of NaCl treatment on the activity of antioxidant enzymes in leaves of oilseed rape seedlings (Brassica napus L.) were studied. The results showed that the relative water content from leaves of oilseed rape seedlings was gradually decreased and the electronic conductivity was increased during 0 - 24 h under 200 mmol.l-1 NaCl treatments. The activity of peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) was gradually increased during 0 - 24 h under 200 mmol.l-1 NaCl stress. After 24 h, the activities of these antioxidases were maximum and subsequently decreased. Quantitative realtime PCR analysis revealed that they were salt-inducible genes and their transcript levels were gradually increased during 0 - 24 h and most abundant after 24 h treatment with 200 mmol.l-1 sodium chloride. Therefore, these results from above indicated that the expressions of POD, SOD and CAT genes were induced by NaCl; the activities of POD, SOD and CAT were increased, which enhanced the tolerance of oilseed oilseed rape plants against NaCl stress

Levinson's Theorem for the Klein-Gordon Equation in Two Dimensions

The two-dimensional Levinson theorem for the Klein-Gordon equation with a cylindrically symmetric potential $V(r)$ is established. It is shown that $N_{m}\pi=\pi (n_{m}^{+}-n_{m}^{-})= [\delta_{m}(M)+\beta_{1}]-[\delta_{m}(-M)+\beta_{2}]$, where $N_{m}$ denotes the difference between the number of bound states of the particle $n_{m}^{+}$ and the ones of antiparticle $n_{m}^{-}$ with a fixed angular momentum $m$, and the $\delta_{m}$ is named phase shifts. The constants $\beta_{1}$ and $\beta_{2}$ are introduced to symbol the critical cases where the half bound states occur at $E=\pm M$.Comment: Revtex file 14 pages, submitted to Phys. Rev.