76 research outputs found
High probability of comorbidities in bronchial asthma in Germany
Clinical experience has shown that allergic and non-allergic respiratory, metabolic, mental, and cardiovascular disorders sometimes
coexist with bronchial asthma. However, no study has been carried out that calculates the chance of manifestation of these
disorders with bronchial asthma in Saarland and Rhineland-Palatinate, Germany. Using ICD10 diagnoses from health care
institutions, the present study systematically analyzed the co-prevalence and odds ratios of comorbidities in the asthma population
in Germany. The odds ratios were adjusted for age and sex for all comorbidities for patients with asthma vs. without asthma.
Bronchial asthma was strongly associated with allergic and with a lesser extent to non-allergic comorbidities: OR 7.02 (95%
CI:6.83–7.22) for allergic rhinitis; OR 4.98 (95%CI:4.67–5.32) allergic conjunctivitis; OR 2.41 (95%CI:2.33–2.52) atopic dermatitis; OR
2.47 (95%CI:2.16–2.82) food allergy, and OR 1.69 (95%CI:1.61–1.78) drug allergy. Interestingly, increased ORs were found for
respiratory diseases: 2.06 (95%CI:1.64–2.58) vocal dysfunction; 1.83 (95%CI:1.74–1.92) pneumonia; 1.78 (95%CI:1.73–1.84) sinusitis;
1.71 (95%CI:1.65–1.78) rhinopharyngitis; 2.55 (95%CI:2.03–3.19) obstructive sleep apnea; 1.42 (95%CI:1.25–1.61) pulmonary
embolism, and 3.75 (95%CI:1.64–8.53) bronchopulmonary aspergillosis. Asthmatics also suffer from psychiatric, metabolic, cardiac
or other comorbidities. Myocardial infarction (OR 0.86, 95%CI:0.79–0.94) did not coexist with asthma. Based on the calculated
chances of manifestation for these comorbidities, especially allergic and respiratory, to a lesser extent also metabolic,
cardiovascular, and mental disorders should be taken into consideration in the diagnostic and treatment strategy of bronchial
asthma
CCAT-prime: a novel telescope for submillimeter astronomy
The CCAT-prime telescope is a 6-meter aperture, crossed-Dragone telescope,
designed for millimeter and sub-millimeter wavelength observations. It will be
located at an altitude of 5600 meters, just below the summit of Cerro
Chajnantor in the high Atacama region of Chile. The telescope's unobscured
optics deliver a field of view of almost 8 degrees over a large, flat focal
plane, enabling it to accommodate current and future instrumentation fielding
>100k diffraction-limited beams for wavelengths less than a millimeter. The
mount is a novel design with the aluminum-tiled mirrors nested inside the
telescope structure. The elevation housing has an integrated shutter that can
enclose the mirrors, protecting them from inclement weather. The telescope is
designed to co-host multiple instruments over its nominal 15 year lifetime. It
will be operated remotely, requiring minimum maintenance and on-site activities
due to the harsh working conditions on the mountain. The design utilizes
nickel-iron alloy (Invar) and carbon-fiber-reinforced polymer (CFRP) materials
in the mirror support structure, achieving a relatively temperature-insensitive
mount. We discuss requirements, specifications, critical design elements, and
the expected performance of the CCAT-prime telescope. The telescope is being
built by CCAT Observatory, Inc., a corporation formed by an international
partnership of universities. More information about CCAT and the CCAT-prime
telescope can be found at www.ccatobservatory.org.Comment: Event: SPIE Astronomical Telescope + Instrumentation, 2018, Austin,
Texas, USA; Proceedings Volume 10700, Ground-based and Airborne Telescopes
VII; 107005X (2018
The intermuscular 3–7 Hz drive is not affected by distal proprioceptive input in myoclonus-dystonia
In dystonia, both sensory malfunctioning and an abnormal intermuscular low-frequency drive of 3–7 Hz have been found, although cause and effect are unknown. It is hypothesized that sensory processing is primarily disturbed and induces this drive. Accordingly, experimenter-controlled sensory input should be able to influence the frequency of the drive. In six genetically confirmed myoclonus-dystonia (MD) patients and six matched controls, the low-frequency drive was studied with intermuscular coherence analysis. External perturbations were applied mechanically to the wrist joint in small frequency bands (0–4, 4–8 and 8–12 Hz; ‘angle protocol) and at single frequencies (1, 5, 7 and 9 Hz; ‘torque’ protocol). The low-frequency drive was found in the neck muscles of 4 MD patients. In these patients, its frequency did not shift due to the perturbation. In the torque protocol, the externally applied frequencies could be detected in all controls and in the two patients without the common drive. The common low-frequency drive was not be affected by external perturbations in MD patients. Furthermore, the torque protocol did not induce intermuscular coherences at the applied frequencies in these patients, as was the case in healthy controls and in patients without the drive. This suggests that the dystonic 3–7 Hz drive is caused by a sensory-independent motor drive and sensory malfunctioning in MD might rather be a consequence than a cause of dystonia
Rhythm Generation through Period Concatenation in Rat Somatosensory Cortex
Rhythmic voltage oscillations resulting from the summed activity of neuronal populations occur in many nervous systems. Contemporary observations suggest that coexistent oscillations interact and, in time, may switch in dominance. We recently reported an example of these interactions recorded from in vitro preparations of rat somatosensory cortex. We found that following an initial interval of coexistent gamma (∼25 ms period) and beta2 (∼40 ms period) rhythms in the superficial and deep cortical layers, respectively, a transition to a synchronous beta1 (∼65 ms period) rhythm in all cortical layers occurred. We proposed that the switch to beta1 activity resulted from the novel mechanism of period concatenation of the faster rhythms: gamma period (25 ms)+beta2 period (40 ms) = beta1 period (65 ms). In this article, we investigate in greater detail the fundamental mechanisms of the beta1 rhythm. To do so we describe additional in vitro experiments that constrain a biologically realistic, yet simplified, computational model of the activity. We use the model to suggest that the dynamic building blocks (or motifs) of the gamma and beta2 rhythms combine to produce a beta1 oscillation that exhibits cross-frequency interactions. Through the combined approach of in vitro experiments and mathematical modeling we isolate the specific components that promote or destroy each rhythm. We propose that mechanisms vital to establishing the beta1 oscillation include strengthened connections between a population of deep layer intrinsically bursting cells and a transition from antidromic to orthodromic spike generation in these cells. We conclude that neural activity in the superficial and deep cortical layers may temporally combine to generate a slower oscillation
Ulnar-sided wrist pain. II. Clinical imaging and treatment
Pain at the ulnar aspect of the wrist is a diagnostic challenge for hand surgeons and radiologists due to the small and complex anatomical structures involved. In this article, imaging modalities including radiography, arthrography, ultrasound (US), computed tomography (CT), CT arthrography, magnetic resonance (MR) imaging, and MR arthrography are compared with regard to differential diagnosis. Clinical imaging findings are reviewed for a more comprehensive understanding of this disorder. Treatments for the common diseases that cause the ulnar-sided wrist pain including extensor carpi ulnaris (ECU) tendonitis, flexor carpi ulnaris (FCU) tendonitis, pisotriquetral arthritis, triangular fibrocartilage complex (TFCC) lesions, ulnar impaction, lunotriquetral (LT) instability, and distal radioulnar joint (DRUJ) instability are reviewed
The Body Action and Posture Coding System (BAP): Development and Reliability
Several methods are available for coding body movement in nonverbal behavior research, but there is no consensus on a reliable coding system that can be used for the study of emotion expression. Adopting an integrative approach, we developed a new method, the Body Action and Posture (BAP) coding system, for the time-aligned micro description of body movement on an anatomical level (different articulations of body parts), a form level (direction and orientation of movement), and a functional level (communicative and self-regulatory functions). We applied the system to a new corpus of acted emotion portrayals, examined its comprehensiveness and demonstrated intercoder reliability at three levels: a) occurrence, b) temporal precision and c) segmentation. We discuss issues for further validation and propose some research applications
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