2,946 research outputs found

    Features of spin-charge separation in the equilibrium conductance through finite rings

    Full text link
    We calculate the conductance through rings with few sites LL described by the tJt-J model, threaded by a magnetic flux Φ\Phi and weakly coupled to conducting leads at two arbitrary sites. The model can describe a circular array of quantum dots with large charging energy UU in comparison with the nearest-neighbor hopping tt. We determine analytically the particular values of Φ\Phi for which a depression of the transmittance is expected as a consequence of spin-charge separation. We show numerically that the equilibrium conductance at zero temperature is depressed at those particular values of Φ\Phi for most systems, in particular at half filling, which might be easier to realize experimentally.Comment: 8 pages, 7 figure

    The Chief HR Officer’s Role in CEO Succession: The View from the Board

    Full text link
    Interviews with 22 members of public and private company boards revealed their beliefs about and expectations for CHROs in the Chief Executive Officer (CEO) succession process. Board members distinguished between credible CHROs who can add significant value to the process and those CHROs who they do not want to see included in almost any aspect of the process. When credible, board members want CHROs to have confidential conversations with the current CEO, to create processes and development plans for potential successors, and to provide their own independent insights regarding candidate strengths and weaknesses. Directors noted that CHROs who add value must display expertise, honesty, transparency, courage, and the ability to build trusting relationships

    Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study

    Get PDF
    Background: C-type natriuretic peptide (CNP) is a known target for promoting growth and has been implicated as a therapeutic opportunity for the prevention and treatment of cardiovascular disease (CVD). This study aimed to explore the effect of CNP on CVD risk using the Mendelian randomization (MR) framework. Methods Instrumental variables mimicking the effects of pharmacological intervention on CNP were identified as uncorrelated genetic variants located in the genes coding for its primary receptors, natriuretic peptide receptors-2 and 3 (NPR2 and NPR3), that associated with height. We performed MR and colocalization analyses to investigate the effects of NPR2 signalling and NPR3 function on CVD outcomes and risk factors. MR estimates were compared to those obtained when considering height variants from throughout the genome. Results: Genetically-proxied reduced NPR3 function was associated with a lower risk of CVD, with odds ratio (OR) 0.74 per standard deviation (SD) higher NPR3-predicted height, and 95% confidence interval (95% CI) 0.64–0.86. This effect was greater in magnitude than observed when considering height variants from throughout the genome. For CVD subtypes, similar MR associations for NPR3-predicted height were observed when considering the outcomes of coronary artery disease (0.75, 95% CI 0.60–0.92), stroke (0.69, 95% CI 0.50–0.95) and heart failure (0.77, 95% CI 0.58–1.02). Consideration of CVD risk factors identified systolic blood pressure (SBP) as a potential mediator of the NPR3-related CVD risk lowering. For stroke, we found that the MR estimate for NPR3 was greater in magnitude than could be explained by a genetically predicted SBP effect alone. Colocalization results largely supported the MR findings, with no evidence of results being driven by effects due to variants in linkage disequilibrium. There was no MR evidence supporting effects of NPR2 on CVD risk, although this null finding could be attributable to fewer genetic variants being identified to instrument this target. Conclusions: This genetic analysis supports the cardioprotective effects of pharmacologically inhibiting NPR3 receptor function, which is only partly mediated by an effect on blood pressure. There was unlikely sufficient statistical power to investigate the cardioprotective effects of NPR2 signalling

    Restoring Rangelands for Nutrition and Health for Humans and Livestock

    Get PDF
    Drylands cover 40% of the global land area and host 2 billion people, of which 90% live in low- or middleincome countries. Drylands often face severe land degradation, low agricultural productivity, rapid population growth, widespread poverty, and poor health. Governance structures and institutions are often eroded. Livestock-based livelihoods, largely depending on seasonal migration are common. Pastoralist communities and their land are highly vulnerable to climate shocks, while there are also changes in land tenure, insecurity/conflicts and rapid infrastructure development. Drylands Transform is an interdisciplinary research project revolving around the UN Sustainable Development Goals (SDGs). The project aim is to contribute new knowledge to a transformative change and sustainable development of drylands in East Africa to help escape the ongoing negative spiral of land, livestock and livelihood degradation. We investigate the links between land health, livelihoods, human well-being, and land management and governance with several study sites along the Kenya-Uganda border. Through strong stakeholder engagement we will explore challenges and pathways towards a social-ecological transformation in these drylands. The entry point is the urgent need to identify and enhance synergies between food and nutrition security (SDG2), land and ecosystem health (SDG15) and governance and justice (SDG16) for sustainable dryland development, aiming to improve health and equity (SDGs 3 and 5), while minimizing trade-offs between agricultural productivity, natural resources management and climate change. We are using innovative field research approaches focusing on livelihood improvement through rangeland (grazing areas) restoration and governance interventions. We will present results from the initial work to assess land health using the Land Degradation Surveillance Framework and explore the links with human health and well-being through household survey data. We will also show how we will co-develop sustainable dryland management options (e.g., field experiments with fodder grasses and shrubs) with local communities and set-up knowledge sharing hubs

    A comparative study of the physiological effects of immersion and bed rest

    Get PDF
    Human physiological response during periods of silicone immersion and bed res

    Self-consistent modeling of the energetic storm particle event of November 10, 2012

    Full text link
    It is thought that solar energetic ions associated with coronal/interplanetary shock waves are accelerated to high energies by the diffusive shock acceleration mechanism. For this mechanism to be efficient, intense magnetic turbulence is needed in the vicinity of the shock. The enhanced turbulence upstream of the shock can be produced self-consistently by the accelerated particles themselves via streaming instability. Comparisons of quasi-linear-theory-based particle acceleration models that include this process with observations have not been fully successful so far, which has motivated the development of acceleration models of a different nature. The aim of this work is to test how well our self-consistent quasi-linear SOLar Particle Acceleration in Coronal Shocks (SOLPACS) simulation code, developed earlier to simulate proton acceleration in coronal shocks, models the particle foreshock region. We applied SOLPACS to model the energetic storm particle (ESP) event observed by the STEREO A spacecraft on November 10, 2012. In the simulations, all but one main input parameter of SOLPACS are fixed by the in-situ plasma measurements from the spacecraft. By comparing a simulated proton energy spectrum at the shock with the observed one, we were able to fix the last simulation input parameter related to the efficiency of particle injection to the acceleration process. A subsequent comparison of simulated proton time-intensity profiles in a number of energy channels with the observed ones shows a very good correspondence throughout the upstream region

    Phenomenon of Cloning and specificity of its usage

    Get PDF
    Cloning is studied by different branches of science. Medicine is interested in cloning because of its ability to transplant special tissues and organs, genetics - with the purpose of studying heredity and succession, sociology deals with moral and ethic aspects of the phenomenon. The paper is devoted to the study of cloning, its special features and usage in different spheres of social life. The article represents main types of cloning, specificity of vegetative and animal cloning and problems of its expansion. The paper also demonstrates the actual topic of nowadays studies connected with human cloning and its aftereffects for science and society. The article may be useful for a wide audience and for people, who are interested in studies of cloning and problems of its realization

    Job strain and risk of obesity: systematic review and meta-analysis of cohort studies

    Get PDF
    Job strain, the most widely used indicator of work stress, is a risk factor for obesity-related disorders such as cardiovascular disease and type 2 diabetes. However, the extent to which job strain is related to the development of obesity itself has not been systematically evaluated. We carried out a systematic review (PubMed and Embase until May 2014) and meta-analysis of cohort studies to address this issue. Eight studies that fulfilled inclusion criteria showed no overall association between job strain and the risk of weight gain (pooled odds ratio for job strain compared with no job strain 1.04, 95% confidence interval (CI) 0.99-1.09, NTotal=18 240) or becoming obese (1.00, 95% CI 0.89-1.13, NTotal=42 222). In addition, a reduction in job strain over time was not associated with lower obesity risk (1.13, 95% CI 0.90-1.41, NTotal=6507). These longitudinal findings do not support the hypothesis that job strain is an important risk factor for obesity or a promising target for obesity prevention.International Journal of Obesity advance online publication, 30 June 2015; doi:10.1038/ijo.2015.103
    corecore