417 research outputs found

    Surface-Initiated Polymer Brushes in the Biomedical Field: Applications in Membrane Science, Biosensing, Cell Culture, Regenerative Medicine and Antibacterial Coatings

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    The PAU survey: photometric calibration of narrow band images

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    The physics of the accelerating Universe (PAU) camera is an optical narrow band and broad band imaging instrument mounted at the prime focus of the William Herschel Telescope. We describe the image calibration procedure of the PAU survey data. We rely on an external photometric catalogue to calibrate our narrow band data using stars that have been observed by both data sets. We fit stellar templates to the stellar broad-band photometry of the Sloan Digital Sky Survey and synthesize narrow band photometry that we compare to the PAUS narrow band data to determine their calibration. Consequently, the PAUS data are in the AB system as inherited from its reference calibrator. We do several tests to check the performance of the calibration. We find it self-consistent when comparing repeated observations of the same objects, with a good overall accuracy to the AB system which we estimate to be at the 2 per cent precision level and no significant trends as a function of narrow band filter or wavelength. Repeated observations allow us to build a spatial map of the illumination pattern of the system. We also check the wavelength dependence of the calibration comparing to stellar spectra. We find that using only blue stars reduces the effects of variations in the stellar template fitting to broad-band colours, improving the overall precision of the calibration to around 1 per cent and its wavelength uniformity. The photometric redshift performance obtained with the PAUS data attests to the validity of our calibration to reach the PAUS science goals

    The PAU Survey: Photometric Calibration of Narrow Band Images

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    The Physics of the Accelerating Universe (PAU) camera is an optical narrow band and broad band imaging instrument mounted at the prime focus of the William Herschel Telescope. We describe the image calibration procedure of the PAU Survey data. We rely on an external photometric catalogue to calibrate our narrow band data using stars that have been observed by both datasets. We fit stellar templates to the stellar broad band photometry of the Sloan Digital Sky Survey and synthesise narrow band photometry that we compare to the PAUS narrow band data to determine their calibration. Consequently, the PAUS data are in the AB system as inherited from its reference calibrator. We do several tests to check the performance of the calibration. We find it self-consistent when comparing repeated observations of the same objects, with a good overall accuracy to the AB system which we estimate to be at the 2\% precision level and no significant trends as a function of narrow band filter or wavelength. Repeated observations allow us to build a spatial map of the illumination pattern of the system. We also check the wavelength dependence of the calibration comparing to stellar spectra. We find that using only blue stars reduces the effects of variations in the stellar template fitting to broad-band colours, improving the overall precision of the calibration to around 1\% and its wavelength uniformity. The photometric redshift performance obtained with the PAUS data attests to the validity of our calibration to reach the PAUS science goals.Comment: 18 pages, 20 figures, accepted for publication in MNRA

    The Physics of the Accelerating Universe Survey: narrow-band image photometry

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    PAUCam is an innovative optical narrow-band imager mounted at the William Herschel Telescope built for the Physics of the Accelerating Universe Survey (PAUS). Its set of 40 filters results in images that are complex to calibrate, with specific instrumental signatures that cannot be processed with traditional data reduction techniques. In this paper, we present two pipelines developed by the PAUS data management team with the objective of producing science-ready catalogues from the uncalibrated raw images. The NIGHTLY pipeline takes care of entire image processing, with bespoke algorithms for photometric calibration and scatter-light correction. The Multi-Epoch and Multi-Band Analysis pipeline performs forced photometry over a reference catalogue to optimize the photometric redshift (photo-z) performance. We verify against spectroscopic observations that the current approach delivers an inter-band photometric calibration of 0.8 per cent across the 40 narrow-band set. The large volume of data produced every night and the rapid survey strategy feedback constraints require operating both pipelines in the Port d’Informació Cientifica data centre with intense parallelization. While alternative algorithms for further improvements in photo-z performance are under investigation, the image calibration and photometry presented in this work already enable state-of-the-art photo-z down to iAB = 23.0

    The PAU Survey: Narrow-band image photometry

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    PAUCam is an innovative optical narrow-band imager mounted at the William Herschel Telescope built for the Physics of the Accelerating Universe Survey (PAUS). Its set of 40 filters results in images that are complex to calibrate, with specific instrumental signatures that cannot be processed with traditional data reduction techniques. In this paper we present two pipelines developed by the PAUS data management team with the objective of producing science-ready catalogues from the uncalibrated raw images. The Nightly pipeline takes care of all image processing, with bespoke algorithms for photometric calibration and scatter-light correction. The Multi-Epoch and Multi-Band Analysis (MEMBA) pipeline performs forced photometry over a reference catalogue to optimize the photometric redshift performance. We verify against spectroscopic observations that the current approach delivers an inter-band photometric calibration of 0.8% across the 40 narrow-band set. The large volume of data produced every night and the rapid survey strategy feedback constraints require operating both pipelines in the Port d'Informaci\'o Cientifica data centre with intense parallelization. While alternative algorithms for further improvements in photo-z performance are under investigation, the image calibration and photometry presented in this work already enable state-of-the-art photometric redshifts down to iAB=23.0.Comment: 32 pages, 26 figures, MNRAS in pres

    Nanoparticles of Selenium as Species with Stronger Physiological Effects in Sheep in Comparison with Sodium Selenite

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    The present study was designed to compare the effects of nano red selenium and sodium selenite on the antioxidative activities of neutrophils and the hematological parameters in sheep. Fifteen sheep were randomly allocated into three groups. Groups 1 and 2 received selenium nanoparticles orally at 1 mg/kg and sodium selenite at 1 mg Se/kg for 10 consecutive days; group 3 served as the control. To assess the degrees of oxidative stress and of lipid peroxidation of the cellular membranes, the levels of thiobarbituric acid reactive substances (TBARS) were determined in serum samples that were collected at different supplementation intervals, i.e., after 0, 10, 20, and 30 days. In addition, hematological parameters in the serum samples were measured by routine procedures. It was found that TBARS levels in groups 1 and 2 were significantly higher on days 20 and 30 compared to the basal level on day 0. It was also found that on day 30, the TBARS activities in both treated groups were significantly higher than those of the controls (P < 0.05). These findings may explain the seemingly paradoxical effects of supplemental selenium on the indicators of oxidative stress, as the levels of TBARS were generally expected to decrease in the presence of selenium. There were no significant differences between the PCV and RBC values in the three groups. The white blood cell count (WBC) in group 1 showed a significant increase on days 20 and 30 in comparison with the control group. However, in group 2, there was a significant increase of the WBC value just on day 20 in comparison with the control group. Also, there were significant increases of the neutrophil counts and significant decreases of the lymphocyte counts on day 10 in group 1, in comparison with those in group 2 and controls, and on days 20 and 30 in groups 1 and 2 in comparison with those in the control group

    IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases

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    IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) may have protective properties in cardiovascular and rheumatic diseases. We here compare these antibodies in systemic rheumatic conditions and study their properties. Anti-PC and anti-MDA was measured using ELISA in patients with SLE (374), RA (354), Mixed connective tissue disease (MCTD, 77), Systemic sclerosis (SSc, 331), Sj\uf6gren\u2019s syndrome (SjS, 324), primary antiphospholipid syndrome (PAPs, 65), undifferentiated connective tissue disease (UCTD, 118) and 515 matched healthy controls (HC). Cardiovascular score (CV) was broadly defined based on clinical disease symptoms. Anti-PC and anti-MDA peptide/protein characterization were compared using a proteomics de novo sequencing approach. anti-MDA and anti-PC were extracted from total IgM. The proportion of Treg cells was determined by flow cytometry. The maximal difference between cases and controls was shown for MCTD: significantly lower IgM Anti-PC but not anti-MDA among patients (median 49.3RU/ml vs 70.4 in healthy controls, p(t-test) = 0.0037). IgM low levels were more prevalent in MCTD, SLE, SjS, SSc and UCTD. IgM anti-PC variable region profiles were different from and more homologous than anti-MDA. Anti-PC but not anti-MDA were significantly negatively correlated with CV in the whole patient group. In contrast to IgM anti-PC, anti-MDA did not promote polarization of Tregs. Taken together, Anti-PC is decreased in MCTD and also in SLE, SjS and SSc but not in other studied diseases. Anti-PC may thus differentiate between these. In contrast, anti-MDA did not show these differences between diseases studied. Anti-PC level is negatively correlated with CV in the patient group cohort. In contrast to anti-PC, anti-MDA did not promote Treg polarization. These findings could have both diagnostic and therapeutic implications, one possibility being active or passive immunization with PC in some rheumatic conditions

    The DES view of the Eridanus supervoid and the CMB cold spot

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    The Cold Spot is a puzzling large-scale feature in the Cosmic Microwave Background temperature maps and its origin has been subject to active debate. As an important foreground structure at low redshift, the Eridanus supervoid was recently detected, but it was subsequently determined that, assuming the standard ΛCDM model, only about 10–20 per cent of the observed temperature depression can be accounted for via its Integrated Sachs–Wolfe imprint. However, R ≳ 100 h−1Mpc supervoids elsewhere in the sky have shown ISW imprints AISW ≈ 5.2 ± 1.6 times stronger than expected from ΛCDM (AISW = 1), which warrants further inspection. Using the Year-3 redMaGiC catalogue of luminous red galaxies from the Dark Energy Survey, here we confirm the detection of the Eridanus supervoid as a significant underdensity in the Cold Spot’s direction at z < 0.2. We also show, with S/N ≳ 5 significance, that the Eridanus supervoid appears as the most prominent large-scale underdensity in the dark matter mass maps that we reconstructed from DES Year-3 gravitational lensing data. While we report no significant anomalies, an interesting aspect is that the amplitude of the lensing signal from the Eridanus supervoid at the Cold Spot centre is about 30 per cent lower than expected from similar peaks found in N-body simulations based on the standard ΛCDM model with parameters Ωm = 0.279 and σ8 = 0.82. Overall, our results confirm the causal relation between these individually rare structures in the cosmic web and in the CMB, motivating more detailed future surveys in the Cold Spot region

    Beyond the 3rd moment: A practical study of using lensing convergence CDFs for cosmology with DES Y3

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    Widefield surveys of the sky probe many clustered scalar fields -- such as galaxy counts, lensing potential, gas pressure, etc. -- that are sensitive to different cosmological and astrophysical processes. Our ability to constrain such processes from these fields depends crucially on the statistics chosen to summarize the field. In this work, we explore the cumulative distribution function (CDF) at multiple scales as a summary of the galaxy lensing convergence field. Using a suite of N-body lightcone simulations, we show the CDFs' constraining power is modestly better than that of the 2nd and 3rd moments of the field, as they approximately capture the information from all moments of the field in a concise data vector. We then study the practical aspects of applying the CDFs to observational data, using the first three years of the Dark Energy Survey (DES Y3) data as an example, and compute the impact of different systematics on the CDFs. The contributions from the point spread function are 2-3 orders of magnitude below the cosmological signal, while those from reduced shear approximation contribute 1%\lesssim 1\% to the signal. Source clustering effects and baryon imprints contribute 110%1-10\%. Enforcing scale cuts to limit systematics-driven biases in parameter constraints degrades these constraints a noticeable amount, and this degradation is similar for the CDFs and the moments. We also detect correlations between the observed convergence field and the shape noise field at 13σ13\sigma. We find that the non-Gaussian correlations in the noise field must be modeled accurately to use the CDFs, or other statistics sensitive to all moments, as a rigorous cosmology tool.Comment: 21 pages, 12 figure

    Dark Energy Survey Year 3 results: Simulation-based cosmological inference with wavelet harmonics, scattering transforms, and moments of weak lensing mass maps. II. cosmological results

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    We present a simulation-based cosmological analysis using a combination of Gaussian and nonGaussian statistics of the weak lensing mass (convergence) maps from the first three years of the Dark Energy Survey. We implement the following: (1) second and third moments; (2) wavelet phase harmonics; (3) the scattering transform. Our analysis is fully based on simulations, spans a space of seven w Cold Dark Matter (wCDM) cosmological parameters, and forward models the most relevant sources of systematics inherent in the data: masks, noise variations, clustering of the sources, intrinsic alignments, and shear and redshift calibration. We implement a neural network compression of the summary statistics, and we estimate the parameter posteriors using a simulation-based inference approach. Including and combining different non-Gaussian statistics is a powerful tool that strongly improves constraints over Gaussian statistics (in our case, the second moments); in particular, the figure of merit ðS8; ΩmÞ is improved by 70% (ΛCDM) and 90% (wCDM). When all the summary statistics are combined, we achieve a 2% constraint on the amplitude of fluctuations parameter S8 ≡ σ8ðΩm=0.3Þ0.5, obtaining S8 ¼ 0.794 0.017 (ΛCDM) and S8 ¼ 0.817 0.021 (wCDM), and a ∼10% constraint on Ωm, obtaining Ωm ¼ 0.259 0.025 (ΛCDM) and Ωm ¼ 0.273 0.029 (wCDM). In the context of the wCDM scenario, these statistics also strengthen the constraints on the parameter w, obtaining w < −0.72. The constraints from different statistics are shown to be internally consistent (with a p-value>0.1 for all combinations of statistics examined). We compare our results to other weak lensing results from the first three years of the Dark Energy Survey data, finding good consistency; we also compare with results from external datasets, such as Planck constraints from the cosmic microwave background, finding statistical agreement, with discrepancies no greater than <2.2σ
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