11,924 research outputs found
Impurity Band Conduction in a High Temperature Ferromagnetic Semiconductor
The band structure of a prototypical dilute ferromagnetic semiconductor,
GaMnAs, is studied across the phase diagram via optical
spectroscopy. We prove that the Fermi energy () resides in a Mn induced
impurity band (IB). This conclusion is based upon careful analysis of the
frequency and temperature dependence of the optical conductivity
(). From our analysis of we infer
a large effective mass () of the carriers, supporting the view that
conduction occurs in an IB. Our results also provide useful insights into the
transport properties of Mn-doped GaAs.Comment: 4 pages, 4 figure
Weekend hospitalization and additional risk of death: An analysis of inpatient data
Objective To assess whether weekend admissions to hospital and/or already being an inpatient on weekend days were associated with any additional mortality risk.Design Retrospective observational survivorship study. We analysed all admissions to the English National Health Service (NHS) during the financial year 2009/10, following up all patients for 30 days after admission and accounting for risk of death associated with diagnosis, co-morbidities, admission history, age, sex, ethnicity, deprivation, seasonality, day of admission and hospital trust, including day of death as a time dependent covariate. The principal analysis was based on time to in-hospital death.Participants National Health Service Hospitals in England.Main Outcome Measures 30 day mortality (in or out of hospital).Results There were 14,217,640 admissions included in the principal analysis, with 187,337 in-hospital deaths reported within 30 days of admission. Admission on weekend days was associated with a considerable increase in risk of subsequent death compared with admission on weekdays, hazard ratio for Sunday versus Wednesday 1.16 (95% CI 1.14 to 1.18; P < .0001), and for Saturday versus Wednesday 1.11 (95% CI 1.09 to 1.13; P < .0001). Hospital stays on weekend days were associated with a lower risk of death than midweek days, hazard ratio for being in hospital on Sunday versus Wednesday 0.92 (95% CI 0.91 to 0.94; P < .0001), and for Saturday versus Wednesday 0.95 (95% CI 0.93 to 0.96; P < .0001). Similar findings were observed on a smaller US data set.Conclusions Admission at the weekend is associated with increased risk of subsequent death within 30 days of admission. The likelihood of death actually occurring is less on a weekend day than on a mid-week day
Inaccurate clinical nodal staging of non-small-cell lung cancer: evidence fro mthe MRC LU22 multicentre randomised trial
An Analytic Equation of State for Ising-like Models
Using an Environmentally Friendly Renormalization we derive, from an
underlying field theory representation, a formal expression for the equation of
state, , that exhibits all desired asymptotic and analyticity
properties in the three limits , and . The only
necessary inputs are the Wilson functions , and
, associated with a renormalization of the transverse vertex
functions. These Wilson functions exhibit a crossover between the Wilson-Fisher
fixed point and the fixed point that controls the coexistence curve.
Restricting to the case N=1, we derive a one-loop equation of state for naturally parameterized by a ratio of non-linear scaling fields. For
we show that a non-parameterized analytic form can be deduced. Various
asymptotic amplitudes are calculated directly from the equation of state in all
three asymptotic limits of interest and comparison made with known results. By
positing a scaling form for the equation of state inspired by the one-loop
result, but adjusted to fit the known values of the critical exponents, we
obtain better agreement with known asymptotic amplitudes.Comment: 10 pages, 2 figure
Nuclear magnetic resonance probes for the Kondo scenario for the 0.7 feature in semiconductor quantum point contact devices
We propose a probe based on nuclear relaxation and Knight shift measurements
for the Kondo scenario for the "0.7 feature" in semiconductor quantum point
contact (QPC) devices. We show that the presence of a bound electron in the QPC
would lead to a much higher rate of nuclear relaxation compared to nuclear
relaxation through exchange of spin with conduction electrons. Furthermore, we
show that the temperature dependence of this nuclear relaxation is very
non-monotonic as opposed to the linear-T relaxation from coupling with
conduction electrons. We present a qualitative analysis for the additional
relaxation due to nuclear spin diffusion (NSD) and study the extent to which
NSD affects the range of validity of our method. The conclusion is that nuclear
relaxation, in combination with Knight shift measurements, can be used to
verify whether the 0.7 feature is indeed due to the presence of a bound
electron in the QPC.Comment: Published version. Appears in a Special Section on the 0.7 Feature
and Interactions in One-Dimensional Systems. 16 page
Tonic inhibition of accumbal spiny neurons by extrasynaptic 4 GABAA receptors modulates the actions of psychostimulants
Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine. We demonstrate that both dopamine D1- and D2-receptor-expressing MSNs (D-MSNs) additionally harbor extrasynaptic GABAARs incorporating α4, β, and δ subunits that mediate tonic inhibition, thereby influencing neuronal excitability. Both the selective δ-GABAAR agonist THIP and DS2, a selective positive allosteric modulator, greatly increased the tonic current of all MSNs from wild-type (WT), but not from δ−/− or α4−/− mice. Coupling dopamine and tonic inhibition, the acute activation of D1 receptors (by a selective agonist or indirectly by amphetamine) greatly enhanced tonic inhibition in D1-MSNs but not D2-MSNs. In contrast, prolonged D2 receptor activation modestly reduced the tonic conductance of D2-MSNs. Behaviorally, WT and constitutive α4−/− mice did not differ in their expression of cocaine-conditioned place preference (CPP). Importantly, however, mice with the α4 deletion specific to D1-expressing neurons (α4D1−/−) showed increased CPP. Furthermore, THIP administered systemically or directly into the NAc of WT, but not α4−/− or α4D1−/− mice, blocked cocaine enhancement of CPP. In comparison, α4D2−/− mice exhibited normal CPP, but no cocaine enhancement. In conclusion, dopamine modulation of GABAergic tonic inhibition of D1- and D2-MSNs provides an intrinsic mechanism to differentially affect their excitability in response to psychostimulants and thereby influence their ability to potentiate conditioned reward. Therefore, α4βδ GABAARs may represent a viable target for the development of novel therapeutics to better understand and influence addictive behaviors
Fisheries in the Development of Indian Economy
Fisheries sector plays a vital role in Indian economy through substantial forex earnings, employment generation and
ensuring nutritional and food security. Contribution of fisheries to total Gross Domestic Product (GDP) at current prices is about
1.3 percent. The fisheries economy of our country has undergone rapid structural changes during the last few decades. The vast
technological options available to fishers led them for a fast shift from traditional to mechanised and motorised fishing methods
in marine fisheries and from traditional to improved seed production and culture practices in inland fisheries
In vivo characterisation of the Golgi matrix protein giantin: linking extracellular matrix secretion and cilia function
Unraveling critical dynamics: The formation and evolution of topological textures
We study the formation of topological textures in a nonequilibrium phase
transition of an overdamped classical O(3) model in 2+1 dimensions. The phase
transition is triggered through an external, time-dependent effective mass,
parameterized by quench timescale \tau. When measured near the end of the
transition the texture separation and the texture width scale respectively as
\tau^(0.39 \pm 0.02) and \tau^(0.46 \pm 0.04), significantly larger than
\tau^(0.25) predicted from the Kibble-Zurek mechanism. We show that
Kibble-Zurek scaling is recovered at very early times but that by the end of
the transition the power-laws result instead from a competition between the
length scale determined at freeze-out and the ordering dynamics of a textured
system. In the context of phase ordering these results suggest that the
multiple length scales characteristic of the late-time ordering of a textured
system derive from the critical dynamics of a single nonequilibrium correlation
length. In the context of defect formation these results imply that significant
evolution of the defect network can occur before the end of the phase
transition. Therefore a quantitative understanding of the defect network at the
end of the phase transition generally requires an understanding of both
critical dynamics and the interactions among topological defects.Comment: 12 pages, revtex, 9 figures in eps forma
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