An automatic deep learning approach for coronary artery calcium segmentation

Coronary artery calcium (CAC) is a significant marker of atherosclerosis and cardiovascular events. In this work we present a system for the automatic quantification of calcium score in ECG-triggered non-contrast enhanced cardiac computed tomography (CT) images. The proposed system uses a supervised deep learning algorithm, i.e. convolutional neural network (CNN) for the segmentation and classification of candidate lesions as coronary or not, previously extracted in the region of the heart using a cardiac atlas. We trained our network with 45 CT volumes; 18 volumes were used to validate the model and 56 to test it. Individual lesions were detected with a sensitivity of 91.24%, a specificity of 95.37% and a positive predicted value (PPV) of 90.5%; comparing calcium score obtained by the system and calcium score manually evaluated by an expert operator, a Pearson coefficient of 0.983 was obtained. A high agreement (Cohen's k = 0.879) between manual and automatic risk prediction was also observed. These results demonstrated that convolutional neural networks can be effectively applied for the automatic segmentation and classification of coronary calcifications

Continuing data analysis of the AS/E grazing incidence X-ray telescope experiment on the OSO-4 satellite

The work to correct and extend the calculation of the theoretical solar X-ray spectrum produced during earlier OSO-4 data analysis is reported along with the work to formulate models of active regions, and compare these models with the experimental values. An atlas of solar X-ray photographs is included, and solar X-ray observations are correlated with the solar wind

Ontological Levels in Histological Imaging

Paper presented at the 9th edition of the Formal Ontology in Information Systems conference, FOIS 2016, July 6–9, 2016, Annecy, FranceThis is the author accepted manuscript. The final version is available from IOS Press via the DOI in this record.In this paper we present an ontological perspective on ongoing work in histological and histopathological imaging involving the quantitative and algorithmic analysis of digitised images of cells and tissues. We present the derivation of consistent histological models from initially captured images of prepared tissue samples as a progression through a number of ontological levels, each populated by its distinctive classes of entities related in systematic ways to entities at other levels. We see this work as contributing to ongoing efforts to provide a consistent and widely accepted suite of ontological resources such as those currently constituting the OBO Foundry, and where possible we draw links between our work and existing ontologies within that suite.This research is supported by EPSRC through funding under grant EP/M023869/1 “Novel context-based segmentation algorithms for intelligent microscopy”

Sub-Doppler laser cooling of potassium atoms

We investigate sub-Doppler laser cooling of bosonic potassium isotopes, whose small hyperfine splitting has so far prevented cooling below the Doppler temperature. We find instead that the combination of a dark optical molasses scheme that naturally arises in this kind of systems and an adiabatic ramping of the laser parameters allows to reach sub-Doppler temperatures for small laser detunings. We demonstrate temperatures as low as 25(3)microK and 47(5)microK in high-density samples of the two isotopes 39K and 41K, respectively. Our findings will find application to other atomic systems.Comment: 7 pages, 9 figure

Temperature and Emission-Measure Profiles Along Long-Lived Solar Coronal Loops Observed with TRACE

We report an initial study of temperature and emission measure distributions along four steady loops observed with the Transition Region and Coronal Explorer (TRACE) at the limb of the Sun. The temperature diagnostic is the filter ratio of the extreme-ultraviolet 171-angstrom and 195-angstrom passbands. The emission measure diagnostic is the count rate in the 171-angstrom passband. We find essentially no temperature variation along the loops. We compare the observed loop structure with theoretical isothermal and nonisothermal static loop structure.Comment: 10 pages, 3 postscript figures (LaTeX, uses aaspp4.sty). Accepted by ApJ Letter

Lapex: A Phoswich balloon experiment for hard X-ray astronomy

Satellite and balloon observations have shown that several classes of celestial objects are hard ( 15 keV) energy band with a sensitivity of approx 10 mCrab has been performed with the UCSD/MIT instrument (A4) on board the HEAO 1 satellite. About 70 X-ray sources were detected, including galactic and extragalactic objects. Hard X-ray emission has been detected in the Galaxy from X-ray pulsars. Extragalactic sources of hard X-ray emission include clusters of galaxies, QSOs, BL Lac objects, Seyfert galaxies. The essential characteristics of the Large Area Phoswich Experiment (LAPEX) for crowded sky field observations are described. It has: (1) a broad energy band of operation (20-300 keV); (2) a 3 sigma sensitivity of about 1 mCrab in 10,000 s of live observing time; and (3) imaging capabilities with an angular resolution of about 20'

Collisional Plasma Models with APEC/APED: Emission Line Diagnostics of Hydrogen-like and Helium-like Ions

New X-ray observatories (Chandra and XMM-Newton) are providing a wealth of high-resolution X-ray spectra in which hydrogen- and helium-like ions are usually strong features. We present results from a new collisional-radiative plasma code, the Astrophysical Plasma Emission Code (APEC), which uses atomic data in the companion Astrophysical Plasma Emission Database (APED) to calculate spectral models for hot plasmas. APED contains the requisite atomic data such as collisional and radiative rates, recombination cross sections, dielectronic recombination rates, and satellite line wavelengths. We compare the APEC results to other plasma codes for hydrogen- and helium-like diagnostics, and test the sensitivity of our results to the number of levels included in the models. We find that dielectronic recombination with hydrogen-like ions into high (n=6-10) principal quantum numbers affects some helium-like line ratios from low-lying (n=2) transitions.Comment: 5 pages, 6 figures, accepted by ApJ Letter

Making the corona and the fast solar wind: a self-consistent simulation for the low-frequency Alfven waves from photosphere to 0.3AU

We show that the coronal heating and the fast solar wind acceleration in the coronal holes are natural consequence of the footpoint fluctuations of the magnetic fields at the photosphere, by performing one-dimensional magnetohydrodynamical simulation with radiative cooling and thermal conduction. We initially set up a static open flux tube with temperature 10^4K rooted at the photosphere. We impose transverse photospheric motions corresponding to the granulations with velocity = 0.7km/s and period between 20 seconds and 30 minutes, which generate outgoing Alfven waves. We self-consistently treat these waves and the plasma heating. After attenuation in the chromosphere by ~85% of the initial energy flux, the outgoing Alfven waves enter the corona and contribute to the heating and acceleration of the plasma mainly by the nonlinear generation of the compressive waves and shocks. Our result clearly shows that the initial cool and static atmosphere is naturally heated up to 10^6K and accelerated to 800km/s.Comment: 4 pages, 3 figures, ApJL, 632, L49, corrections of mistypes in eqs.(3) & (5), Mpeg movie for fig.1 (simulation result) is available at http://www-tap.scphys.kyoto-u.ac.jp/~stakeru/research/suzuki_200506.mp

Infrared Spectroscopy of a Massive Obscured Star Cluster in the Antennae Galaxies (NGC 4038/4039) with NIRSPEC

We present infrared spectroscopy of the Antennae Galaxies (NGC 4038/4039) with NIRSPEC at the W. M. Keck Observatory. We imaged the star clusters in the vicinity of the southern nucleus (NGC 4039) in 0.39" seeing in K-band using NIRSPEC's slit-viewing camera. The brightest star cluster revealed in the near-IR (M_K(0) = -17.9) is insignificant optically, but coincident with the highest surface brightness peak in the mid-IR (12-18 micron) ISO image presented by Mirabel et al. (1998). We obtained high signal-to-noise 2.03 - 2.45 micron spectra of the nucleus and the obscured star cluster at R ~ 1900. The cluster is very young (4 Myr old), massive (16e6 M_sun), and compact (density ~ 115 M_sun pc^(-3) within a 32 pc half-light radius), assuming a Salpeter IMF (0.1 - 100 M_sun). Its hot stars have a radiation field characterized by T_eff ~ 39,000 K, and they ionize a compact H II region with n_e ~ 1e4 cm^(-3). The stars are deeply embedded in gas and dust (A_V ~ 9-10 mag), and their strong FUV field powers a clumpy photodissociation region with densities n_H >= 1e5 cm^(-3) on scales of up to 200 pc, radiating L[H_2 1-0 S(1)] = 9600 L_sun.Comment: 4 pages, 5 embedded figures. To appear in proceedings of 33d ESLAB Symposium: Star Formation from the Small to the Large Scale, held in Noordwijk, The Netherlands, Nov. 1999. Also available at http://astro.berkeley.edu/~agilber

A solar active region loop compared with a 2D MHD model

We analyzed a coronal loop observed with the Normal Incidence Spectrometer (NIS), which is part of the Coronal Diagnostic Spectrometer (CDS) on board the Solar and Heliospheric Observatory (SOHO). The measured Doppler shifts and proper motions along the selected loop strongly indicate unidirectional flows. Analysing the Emission Measure Curves of the observed spectral lines, we estimated that the temperature along the loop was about 380000 K. We adapted a solution of the ideal MHD steady equations to our set of measurements. The derived energy balance along the loop, as well as the advantages/disadvantages of this MHD model for understanding the characteristics of solar coronal loops are discussed.Comment: A&A in press, 10 pages, 6 figure