R. v. Conway: UnChartered Territory for Administrative Tribunals

In R. v. Conway, the Supreme Court of Canada reformulated and simplified the test for when an administrative tribunal is a court of competent jurisdiction for the purposes of considering constitutional questions and ordering Charter remedies. Previously, there were two different tests for when a tribunal was a court of competent jurisdiction: one for when an administrative tribunal was considering whether a legislative provision was constitutional, and a second when it was considering whether it had jurisdiction to grant a Charter remedy. Conway amalgamated and simplified the tests. In so doing, the Supreme Court made clear that administrative tribunals should play a primary role in determining Charter issues and that the fundamental issue is whether a tribunal can consider questions of law. It is possible, under Conway, that many more tribunals will be considered courts of competent jurisdiction. However, as the powers of tribunals are constrained by the legislative scheme, in practice the change may not be as significant as initially thought

R. v. Conway: UnChartered Territory for Administrative Tribunals

In R. v. Conway, the Supreme Court of Canada reformulated and simplified the test for when an administrative tribunal is a court of competent jurisdiction for the purposes of considering constitutional questions and ordering Charter remedies. Previously, there were two different tests for when a tribunal was a court of competent jurisdiction: one for when an administrative tribunal was considering whether a legislative provision was constitutional, and a second when it was considering whether it had jurisdiction to grant a Charter remedy. Conway amalgamated and simplified the tests. In so doing, the Supreme Court made clear that administrative tribunals should play a primary role in determining Charter issues and that the fundamental issue is whether a tribunal can consider questions of law. It is possible, under Conway, that many more tribunals will be considered courts of competent jurisdiction. However, as the powers of tribunals are constrained by the legislative scheme, in practice the change may not be as significant as initially thought

R. v. Comeau: A Crack In the Wall?

In 2012, one man’s journey from New Brunswick to Quebec in pursuit of cheap beer sparked a fierce constitutional debate about the role of interprovincial trade in Canada. In a booze run that has since made Canadian legal history, G rard Comeau drove from his home in Tracadie, New Brunswick to the Listiguj First Nation Indian Reserve in Quebec, where alcohol is sold at a cheap price. While there, he stocked up on 15 cases of beer and three bottles of liquor, purchased from three different stores. Unbeknownst to him, Mr. Comeau had been under surveillance in his sojourn into Quebec. When he crossed back over into New Brunswick, Mr. Comeau’s vehicle was intercepted by the RCMP, the alcohol was seized, and Mr. Comeau was charged and fined close to $300 under section 134(b) of the New Brunswick Liquor Control Act, which prohibits possession of liquor not purchased from the New Brunswick Liquor Corporation in excess of a prescribed amount

Managing Access to Biobanks:How Can We Reconcile Privacy and Public Interests in Genetic Research?

This article is concerned with the ultimate objectives of genetic biobanks set up to promote the public interest—being the sharing of samples and data for medical research—and the consequences for personal privacy of realising them. Our aim is to chart the values, interests and principles in play, to consider the challenges of realizing biobanking objectives on a global scale, and to propose viable ways forward that ensure, as far as possible, that access provisions remain fit for purpose throughout the entire life of a biobank, while adequately protecting the privacy interests at stake. It is argued that key features in any robust access model must include mechanisms to (a) maintain participant trust in management of the resource and to measure and respond to participants’ expectations, (b) facilitate and promote the sharing of benefits, and (c) respond timeously and effectively to new challenges

Immunoreactivity of the AAA plus chaperone ClpB from Leptospira interrogans with sera from Leptospira-infected animals

Citation: Krajewska, J., Arent, Z., Wieckowski, D., Zolkiewski, M., & Kedzierska-Mieszkowska, S. (2016). Immunoreactivity of the AAA plus chaperone ClpB from Leptospira interrogans with sera from Leptospira-infected animals. Bmc Microbiology, 16, 8. doi:10.1186/s12866-016-0774-8Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the Leptospira virulence remain mostly unknown. Recently, it has been demonstrated that L. interrogans ClpB (ClpB(Li)) is essential for bacterial survival under stressful conditions and also during infection. The aim of this study was to provide further insight into the role of ClpB in L. interrogans and answer the question whether ClpB(Li) as a potential virulence factor may be a target of the humoral immune response during leptospiral infections in mammals. Results: ClpB(Li) consists of 860 amino acid residues with a predicted molecular mass of 96.3 kDa and shows multi-domain organization similar to that of the well-characterized ClpB from Escherichia coli. The amino acid sequence identity between ClpB(Li) and E. coli ClpB is 52 %. The coding sequence of the clpB(Li) gene was cloned and expressed in E. coli BL21(DE3) strain. Immunoreactivity of the recombinant ClpB(Li) protein was assessed with the sera collected from Leptospira-infected animals and uninfected healthy controls. Western blotting and ELISA analysis demonstrated that ClpB(Li) activates the host immune system, as evidenced by an increased level of antibodies against ClpB(Li) in the sera from infected animals, as compared to the control group. Additionally, ClpB(Li) was found in kidney tissues of Leptospira-infected hamsters. Conclusions: ClpB(Li) is both synthesized and immunogenic during the infectious process, further supporting its involvement in the pathogenicity of Leptospira. In addition, the immunological properties of ClpB(Li) point to its potential value as a diagnostic antigen for the detection of leptospirosis

Beliefs about back pain and pain management behaviours, and their associations in the general population : a systematic review

This work was supported by the Arthritis Research UK/Medical Research Council Centre for Musculoskeletal Health and Work (grant number: 20665).Peer reviewedPublisher PD

Breit-Wheeler Process in Intense Short Laser Pulses

Energy-angular distributions of electron-positron pair creation in collisions of a laser beam and a nonlaser photon are calculated using the $S$-matrix formalism. The laser field is modeled as a finite pulse, similar to the formulation introduced in our recent paper in the context of Compton scattering [Phys. Rev. A {\bf 85}, 062102 (2012)]. The nonperturbative regime of pair creation is considered here. The energy spectra of created particles are compared with the corresponding spectra obtained using the modulated plane wave approximation for the driving laser field. A very good agreement in these two cases is observed, provided that the laser pulse is sufficiently long. For short pulse durations, this agreement breaks down. The sensitivity of pair production to the polarization of a driving pulse is also investigated. We show that in the nonperturbative regime, the pair creation yields depend on the polarization of the pulse, reaching their maximal values for the linear polarization. Therefore, we focus on this case. Specifically, we analyze the dependence of pair creation on the relative configuration of linear polarizations of the laser pulse and the nonlaser photon. Lastly, we investigate the carrier-envelope phase effect on angular distributions of created particles, suggesting the possibility of phase control in relation to the pair creation processes.Comment: 13 pages, 8 figure

Kinetics of the urea–urease clock reaction with urease immobilized in hydrogel beads

Feedback driven by enzyme catalyzed reactions occurs widely in biology and has been well characterized in single celled organisms such as yeast. There are still few examples of robust enzyme oscillators in vitro that might be used to study nonlinear dynamical behavior. One of the simplest is the urea–urease reaction that displays autocatalysis driven by the increase in pH accompanying the production of ammonia. A clock reaction was obtained from low to high pH in batch reactor and bistability and oscillations were reported in a continuous flow rector. However, the oscillations were found to be irreproducible and one contributing factor may be the lack of stability of the enzyme in solution at room temperature. Here, we investigated the effect of immobilizing urease in thiol-poly(ethylene glycol) acrylate (PEGDA) hydrogel beads, prepared using emulsion polymerization, on the urea–urease reaction. The resultant mm-sized beads were found to reproduce the pH clock and, under the conditions employed here, the stability of the enzyme was increased from hours to days

Analysis of fungal air pollution using different samplers

The aim of this study was the analysis of fungal air pollution in different rooms using different the air samplers. Air for mycological studies was collected from various hospital rooms. To monitor fungal air pollution were used samplers: SAS SUPER 100 (pbi-international), MAS 100 (Merck) and AIR IDEAL (BioMerieux). We found differences in CFU/L values in depending on hospital room and the air sampler type. The CFU/L values of air samples taken by the AIR IDEAL ranged from 350 to 850 and (724.2 ± 159.9), and the CFU/L values of air samples taken by the sampler SAS SUPER 100 ranged from 160 to 800 (455.3 ± 250.73). The CFU/L values of air samples taken by the MAS 100 sampler varied from 50 to 1340 (302.5±56.6) From the air samples of both samplers was incubated 6 genera/species of fungi. Candia albicans fungi species and genus Penicillium species were most frequently isolated from SAS Super 100 sampler, and Penicillium species from the AIR IDEAL sampler. From the air samples of MAS 100 was isolated 11 types/species of fungi and in air samples of SAS Super 100 was isolated 7 types/species. Significant differences of CFU/L values in the tested rooms were found in depending on the used sampler. Mycological analysis of the obtained cultures from air samples suggests that there is not same isolation of fungi using the different samplers