Aerodynamic performance of flared fan nozzles used as inlets

Tests were conducted in a low speed wind tunnel to determine the aerodynamic performance of several flared fan nozzles. Each of the flared nozzles was a downstream-facing inlet to a model fan that was used to simulate a variable pitch fan during reverse thrust operation. The total pressure recovery of each of the flared nozzles as well as that of an unflared nozzle and a serrated flare nozzle was obtained for comparison. The aerodynamic performance of a selected flared nozzle was considered in further detail. The nozzle surface pressures for a flared nozzle were also determined. Results indicated that the differences in aerodynamic performance among the nozzles were most apparent at the wind-tunnel-off condition. A nonzero free stream velocity significantly reduced the perforamnce of all the nozzles, and crosswind flow (free stream flow perpendicular to the model axis) further reduced the performance of the nozzles. The unflared nozzle and the serrated flare nozzle had reduced aerodynamic performance compared to a solid surface flared nozzle

Dynamics of a flexible rotor in magnetic bearings

Discussed is a magnetic bearing which was designed and tested in a flexible rotor both as support bearings and as a vibration controller. The design of the bearing is described and the effect of control circuit bandwidth determined. Both stiffness and damping coefficients were measured and calculated for the bearing with good agreement. The bearings were then placed in a single mass rotor as support bearings and the machine run through two critical speeds. Measurements were made of the vibration response in plain bushings and magnetic bearings. Comparisons were also made of the theoretical calculations with the measured peak unbalance response speeds. Finally, runs were made with the magnetic bearing used as a vibration controller

Mechanical behaviour of standardized, endoskeleton-including hip spacers implanted into composite femurs

Two-stage reconstruction using an antibiotic loaded cement spacer is the preferred treatment method of late hip joint infections. Hip spacers maintain stability of the joint and length of the limb during treatment period. However, as the material strength of bone cement (PMMA) is limited, spacer fractures led to serious complications in the past. This study investigated the load capacity of custom made hip spacers, developed at the 'Klinik für Orthopädie und Orthopädische Chirurgie' (Universitätsklinikum des Saarlandes, Homburg / Saar, Germany), and implanted into composite femurs. In a quasi-static test, non-reinforced spacers tolerated hip joint loads of about 3000 N, whereas reinforced spacers with titanium-grade-two endoskeletons doubled this load up to 6000 N. Even for cyclic loading, endoskeleton-including hip spacers tolerated loads of >4500 N with 500,000 load cycles. Thus, an endoskeleton-including spacer should provide a mobile and functional joint through the treatment course. A generated FE-model was used to determine the fracture stresses and allows for further sensitivity analysis

Seal Oil Piping Vibration On An Oil-Free Screw Compressor In An FPSO Application.

Case StudyA dry screw compressor skid was fabricated for offshore service that included oil buffered mechanical seals on the compressor. During shop testing, excessive seal oil piping vibration was observed that resulted in pipe component failures. The oil system was designed to include a common lube and seal oil system with a pump design pressure of 590 psi. There were six oil control valves on the system, including a lube oil pressure control valve, one flow control valve on the inlet end of the compressor, another flow control valve on the discharge end, two differential pressure controllers to maintain differential pressure on the seals for each end of the compressor, as well as a back pressure control valve for the oil system. Vibration and pressure pulsation measurements indicated that the response was at the pocket pass frequency of 206 Hz. The source was determined to be at the compressor. Arrangement of the control valves and control sensing lines were likely contributors to the severity of the response. Modification to the seal oil system included addition of several volumes at strategic locations to change the acoustical characteristics of the oil system to reduce the shaking forces in the pipe system. These changes along with pipe support modifications and changes to the control valve sensing lines were successful at reducing the pipe pulsations and vibration response to acceptable levels

Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b/CD18

Polymorphonuclear neutrophils (PMNs) play a critical role in the innate immune response to invading pathogens. However, dysregulated mucosal trafficking of PMNs and associated epithelial tissue damage is a pathological hallmark of numerous inflammatory conditions including inflammatory bowel disease. The glycoprotein CD11b/CD18 plays a well‐described role in regulating PMN transepithelial migration and PMN inflammatory functions. Previous studies have demonstrated that targeting of the N‐linked glycan Lewis X on CD11b blocks PMN transepithelial migration (TEpM). Given evidence of glycosylation‐dependent regulation of CD11b/CD18 function, we performed MALDI TOF Mass Spectrometry (MS) analyses on CD11b/CD18 purified from human PMNs. Unusual glycan epitopes identified on CD11b/CD18 included high Mannose oligosaccharides recognized by the Galanthus Nivalis lectin and biantennary galactosylated N‐glycans recognized by the Phaseolus Vulgaris erythroagglutinin lectin. Importantly, we show that selective targeting of glycans on CD11b with such lectins results in altered intracellular signaling events that inhibit TEpM and differentially affect key PMN inflammatory functions including phagocytosis, superoxide release and apoptosis. Taken together, these data demonstrate that discrete glycan motifs expressed on CD11b/CD18 such as biantennary galactose could represent novel targets for selective manipulation of CD11b function and reduction of PMN‐associated tissue damage in chronic inflammatory diseases.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154461/1/fsb220152-sup-0003-FigS3.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154461/2/fsb220152_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154461/3/fsb220152-sup-0004-TableS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154461/4/fsb220152-sup-0001-FigS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154461/5/fsb220152.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154461/6/fsb220152-sup-0002-FigS2.pd

Micromechanical properties and structural characterization of modern inarticulated brachiopod shells

[1] We investigated micromechanical properties and ultrastructure ofthe shells of the modern brachiopod species Lingula anatina, Disciniscalaevis, and Discradisca stella with scanning electron microscopy (SEM,EDX), transmission electron microscopy (TEM) and Vickers microhardnessindentation analyses. The shells are composed of two distinct layers, anouter primary layer and an inner secondary layer. Except for the primarylayer in Lingula anatina, which is composed entirely of organic matter,all other shell layers are laminated organic/inorganic composites. Theorganic matter is built of chitin fibers, which provide the matrix forthe incorporation of calcium phosphate. Amorphous calcium phosphate inthe outer, primary layer and crystalline apatite is deposited into theinner, secondary layer of the shell. Apatite crystallite sizes in theumbonal region of the shell are about 50 x 50 nm, while within thevalves crystallite sizes are significantly smaller, averanging 10 x 25nm. There is great variation in hardness values between shell layers andbetween the investigated brachiopod species. The microhardness of theinvestigated shells is significantly lower than that of inorganichydroxyapatite. This is caused by the predominantly organic materialcomponent that in these shells is either developed as purely organiclayers or as an organic fibrous matrix reinforced by crystallites. Ourresults show that this particular fiber composite material is veryefficient for the protection and the support of the soft animal tissue.It lowers the probability of crack formation and effectively impedescrack propagation perpendicular to the shell by crack-deviationmechanisms. The high degree of mechanical stability and toughness isachieved by two design features. First, there is the fiber compositematerial which overcomes some detrimental and enhances some advantageousproperties of the single constituents, that is the softness andflexibility of chitin and the hardness and brittleness of apatite.Second, there is a hierarchical structuring from the nanometer to amicrometer level. We could identify at least seven levels of hierarchywithin the shells

Small scale systems of galaxies I. Photometric and spectroscopic properties of members

This paper is the first of a series addressed to the investigation of galaxy formation/evolution in small scale systems of galaxies (SSSGs) which are located in low density cosmic environments. Our algorithm for SSSG selection includes galaxy systems of 2 or more galaxies lying within 1000 km/s and a 200 h_{100}^{-1} kpc radius volume. We present the analysis of the photometric and spectroscopic properties of 19 member galaxies belonging to a sample of 11 SSSGs. In the $\mu_e - r_e$ plane, early-type members may be considered "ordinary", not "bright" galaxies in the definition given by Capaccioli et al.(1992) with a significant fraction of galaxies having a disk or disky isophotes. We do not detect fine structure and signatures of recent interaction events in the early-type galaxy population, a picture also confirmed by the spectroscopy. At odd, there are several spiral members with open arm configurations as expected in interacting systems. At the same time, emission lines in the spectra of spiral members fall in the HII regions regime defined with diagnostic diagrams (Veilleux & Osterbrock 1987). None of the objects displays unambiguous indication of nuclear activity, although fourspiral nuclei could be ascribed to the class of Seyferts. The star formation rate seems enhanced over the average expected in spiral galaxies only for poorer SSSGs in particular pairs (<50 solar masses per year) but without being in the range of starburst systems.Comment: 24 pages, including 6 figures and 6 tables. Accepted for publication in A

Impact of Software Modeling on the Accuracy of Perfusion MRI in Glioma

PURPOSE: To determine whether differences in modeling implementation will impact the correction of leakage effects (from blood brain barrier disruption) and relative cerebral blood volume (rCBV) calculations as measured on T2*-weighted dynamic susceptibility-weighted contrast-enhanced (DSC)-MRI at 3T field strength. MATERIALS AND METHODS: This HIPAA-compliant study included 52 glioma patients undergoing DSC-MRI. Thirty-six patients underwent both non Preload Dose (PLD) and PLD-corrected DSC acquisitions, with sixteen patients undergoing PLD-corrected acquisitions only. For each acquisition, we generated two sets of rCBV metrics using two separate, widely published, FDA-approved commercial software packages: IB Neuro (IBN) and NordicICE (NICE). We calculated 4 rCBV metrics within tumor volumes: mean rCBV, mode rCBV, percentage of voxels with rCBV > 1.75 (%>1.75), and percentage of voxels with rCBV > 1.0 (Fractional Tumor Burden or FTB). We determined Pearson (r) and Spearman (ρ) correlations between non-PLD- and PLD-corrected metrics. In a subset of recurrent glioblastoma patients (n=25), we determined Receiver Operator Characteristic (ROC) Areas-Under-Curve (AUC) for FTB accuracy to predict the tissue diagnosis of tumor recurrence versus post-treatment effect (PTRE). We also determined correlations between rCBV and microvessel area (MVA) from stereotactic biopsies (n=29) in twelve patients. RESULTS: Using IBN, rCBV metrics correlated highly between non-PLD- and PLD-corrected conditions for FTB (r=0.96, ρ=0.94), %>1.75 (r=0.93, ρ=0.91), mean (r=0.87, ρ=0.86) and mode (r=0.78, ρ=0.76). These correlations dropped substantially with NICE. Using FTB, IBN was more accurate than NICE in diagnosing tumor vs PTRE (AUC=0.85 vs 0.67) (p<0.01). The highest rCBV-MVA correlations required PLD and IBN (r=0.64, ρ=0.58, p=0.001). CONCLUSIONS: Different implementations of perfusion MRI software modeling can impact the accuracy of leakage correction, rCBV calculation, and correlations with histologic benchmarks

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade

Elaboration of tumor necrosis factor (TNF) is a very early event in development of ischemia/reperfusion injury pathophysiology. Therefore, TNF may be a prominent mediator of endothelial cell and vascular wall dysfunction in sickle cell anemia, a hypothesis we addressed using NY1DD, S+SAntilles, and SS‐BERK sickle transgenic mice. Transfusion experiments revealed participation of abnormally activated blood monocytes exerting an endothelial activating effect, dependent upon Egr‐1 in both vessel wall and blood cells, and upon NFκB(p50) in a blood cell only. Involvement of TNF was identified by beneficial impact from TNF blockers, etanercept and infliximab, with less benefit from an IL‐1 blocker, anakinra. In therapeutic studies, etanercept ameliorated multiple disturbances of the murine sickle condition: monocyte activation, blood biomarkers of inflammation, low platelet count and Hb, vascular stasis triggered by hypoxia/reoxygenation (but not if triggered by hemin infusion), tissue production of neuro‐inflammatory mediators, endothelial activation (monitored by tissue factor and VCAM‐1 expression), histopathologic liver injury, and three surrogate markers of pulmonary hypertension (perivascular inflammatory aggregates, arteriolar muscularization, and right ventricular mean systolic pressure). In aggregate, these studies identify a prominent—and possibly dominant—role for an abnormal monocyte‐TNF‐endothelial activation axis in the sickle context. Its presence, plus the many benefits of etanercept observed here, argue that pilot testing of TNF blockade should be considered for human sickle cell anemia, a challenging but achievable translational research goal