Motion Estimation and Reconstruction of a Heart Surface by Means of 2D-/3D-Membrane Models

In order to assist surgeons during minimally invasive interventions on the beating heart, it would be helpful to develop a robotic surgery system, which synchronizes the instruments with the heart surface, so that their positions do not change relative to the point of interest (POI). The synchronization of the robotic manipulators requires an estimation of the heart surface motion. In this paper, a modelbased motion estimation of the heart surface is presented. The motion of a partition of the heart surface is modelled by means of a thin or thick vibrating membrane in order to represent the epicardial surface or the connected epicard and myocard. The membrane motion is described by means of a system of coupled linear partial differential equations (PDEs), whose 3D-input function is assumed to be known. After spatial discretization of the PDE solution space by the Finite Spectral Element Method, a bank of lumped systems is obtained. A Kalman filter is used to estimate the state of the lumped systems by incorporating noisy measurements of the heart surface. Measurements can be the position or velocity of sonomicrometry-based sensors or of certain landmarks, which are tracked by optical sensors. With the model-based estimation it is possible to reconstruct the entire partition of the heart surface even at non-measurement points and thus at each POI

Induced Gamma-band Activity Elicited by Visual Representation of Unattended Objects

Peer reviewedPostprin

Transport of Mars-Crossing Asteroids from the Quasi-Hilda Region

We employ set oriented methods in combination with graph partitioning algorithms to identify key dynamical regions in the Sun-Jupiter-particle three-body system. Transport rates from a region near the 3:2 Hilda resonance into the realm of orbits crossing Mars' orbit are computed. In contrast to common numerical approaches, our technique does not depend on single long term simulations of the underlying model. Thus, our statistical results are particularly reliable since they are not affected by a dynamical behavior which is almost nonergodic (i.e., dominated by strongly almost invariant sets)

Probing the Earth's interior with a large-volume liquid scintillator detector

A future large-volume liquid scintillator detector would provide a high-statistics measurement of terrestrial antineutrinos originating from $\beta$-decays of the uranium and thorium chains. In addition, the forward displacement of the neutron in the detection reaction $\bar\nu_e+p\to n+e^+$ provides directional information. We investigate the requirements on such detectors to distinguish between certain geophysical models on the basis of the angular dependence of the geoneutrino flux. Our analysis is based on a Monte-Carlo simulation with different levels of light yield, considering both unloaded and gadolinium-loaded scintillators. We find that a 50 kt detector such as the proposed LENA (Low Energy Neutrino Astronomy) will detect deviations from isotropy of the geoneutrino flux significantly. However, with an unloaded scintillator the time needed for a useful discrimination between different geophysical models is too large if one uses the directional information alone. A Gd-loaded scintillator improves the situation considerably, although a 50 kt detector would still need several decades to distinguish between a geophysical reference model and one with a large neutrino source in the Earth's core. However, a high-statistics measurement of the total geoneutrino flux and its spectrum still provides an extremely useful glance at the Earth's interior.Comment: 21 pages, 9 figures. Minor changes, version accepted for publication in Astroparticle Physic

Tn6188 - A Novel Transposon in Listeria monocytogenes Responsible for Tolerance to Benzalkonium Chloride

peer-reviewedControlling the food-borne pathogen Listeria (L.) monocytogenes is of great importance from a food safety perspective, and thus for human health. The consequences of failures in this regard have been exemplified by recent large listeriosis outbreaks in the USA and Europe. It is thus particularly notable that tolerance to quaternary ammonium compounds such as benzalkonium chloride (BC) has been observed in many L. monocytogenes strains. However, the molecular determinants and mechanisms of BC tolerance of L. monocytogenes are still largely unknown. Here we describe Tn6188, a novel transposon in L. monocytogenes conferring tolerance to BC. Tn6188 is related to Tn554 from Staphylococcus (S.) aureus and other Tn554-like transposons such as Tn558, Tn559 and Tn5406 found in various Firmicutes. Tn6188 comprises 5117 bp, is integrated chromosomally within the radC gene and consists of three transposase genes (tnpABC) as well as genes encoding a putative transcriptional regulator and QacH, a small multidrug resistance protein family (SMR) transporter putatively associated with export of BC that shows high amino acid identity to Smr/QacC from S. aureus and to EmrE from Escherichia coli. We screened 91 L. monocytogenes strains for the presence of Tn6188 by PCR and found Tn6188 in 10 of the analyzed strains. These isolates were from food and food processing environments and predominantly from serovar 1/2a. L. monocytogenes strains harboring Tn6188 had significantly higher BC minimum inhibitory concentrations (MICs) (28.5 ± 4.7 mg/l) than strains without Tn6188 (14 ± 3.2 mg/l). Using quantitative reverse transcriptase PCR we could show a significant increase in qacH expression in the presence of BC. QacH deletion mutants were generated in two L. monocytogenes strains and growth analysis revealed that ΔqacH strains had lower BC MICs than wildtype strains. In conclusion, our results provide evidence that Tn6188 is responsible for BC tolerance in various L. monocytogenes strains.This work was supported by a grant from the Austrian Science Fund (FWF, http://www.fwf.ac.at/) to SSE (grant no. P22703‐B17), by the European Union funded integrated project BIOTRACER (contract no. 036272) under the 6th RTD framework and by the EU grant FP7‐KBBE‐2010‐4 (FOODSEG)

Status quo und Entwicklungstendenzen interner Unternehmensberatungen:Ergebnisse einer empirischen Untersuchung

Das vorliegende Arbeitspapier gründet sich auf eine Befragung zum Thema "Funktion und Organisation interner Unternehmensberatungen" unter besonderer Berücksichtigung des Bankensektors. Es verfolgt das Ziel, die momentane Bedeutung sowie die zukünftige Entwicklung der Beratungsleistungen, Funktionen und Organisation zu identifizieren. Daraus wird abgeleitet, auf welche Weise die besonderen Stärken von internen Beratungen wahrgenommen werden und welche Richtung die weitere Entwicklung nehmen könnte

Borehole Equilibration: Testing a New Method to Monitor the Isotopic Composition of Tree Xylem Water in situ

Forest water use has been difficult to quantify. One promising approach is to measure the isotopic composition of plant water, e.g., the transpired water vapor or xylem water. Because different water sources, e.g., groundwater versus shallow soil water, often show different isotopic signatures, isotopes can be used to investigate the depths from which plants take up their water and how this changes over time. Traditionally such measurements have relied on the extraction of wood samples, which provide limited time resolution at great expense, and risk possible artifacts. Utilizing a borehole drilled through a tree's stem, we propose a new method based on the notion that water vapor in a slow-moving airstream approaches isotopic equilibration with the much greater mass of liquid water in the xylem. We present two empirical data sets showing that the method can work in practice. We then present a theoretical model estimating equilibration times and exploring the limits at which the approach will fail. The method provides a simple, cheap, and accurate means of continuously estimating the isotopic composition of the source water for transpiration