Synthesis of various highly halogenated monomers and polymers

Halogenated polyurethane and polycarbonate are synthesized and found to be LOX compatible but dependent upon the type nitrogen bonding

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence.

Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents. However, far less is known about the role for hypocretin transmission in regulating ongoing cocaine-taking behavior. Here, we investigated the effects of the selective Hcrt-R1 antagonist SB-334867 on cocaine intake, as measured by intravenous (IV) cocaine self-administration in rats. The stimulatory effects of cocaine on brain reward systems contribute to the establishment and maintenance of cocaine-taking behaviors. Therefore, we also assessed the effects of SB-334867 on the reward-enhancing properties of cocaine, as measured by cocaine-induced lowering of intracranial self-stimulation (ICSS) thresholds. Finally, to definitively establish a role for Hcrt-R1 in regulating cocaine intake, we assessed IV cocaine self-administration in Hcrt-R1 knockout mice. We found that SB-334867 (1-4 mg/kg) dose-dependently decreased cocaine (0.5 mg/kg/infusion) self-administration in rats but did not alter responding for food rewards under the same schedule of reinforcement. This suggests that SB-334867 decreased cocaine reinforcement without negatively impacting operant performance. SB-334867 (1-4 mg/kg) also dose-dependently attenuated the stimulatory effects of cocaine (10 mg/kg) on brain reward systems, as measured by reversal of cocaine-induced lowering of ICSS thresholds in rats. Finally, we found that Hcrt-R1 knockout mice self-administered far less cocaine than wildtype mice across the entire dose-response function. These data demonstrate that Hcrt-R1 play an important role in regulating the reinforcing and reward-enhancing properties of cocaine and suggest that hypocretin transmission is likely essential for establishing and maintaining the cocaine habit in human addicts

Stretched Exponential Relaxation in the Biased Random Voter Model

We study the relaxation properties of the voter model with i.i.d. random bias. We prove under mild condions that the disorder-averaged relaxation of this biased random voter model is faster than a stretched exponential with exponent $d/(d+\alpha)$, where $0<\alpha\le 2$ depends on the transition rates of the non-biased voter model. Under an additional assumption, we show that the above upper bound is optimal. The main ingredient of our proof is a result of Donsker and Varadhan (1979).Comment: 14 pages, AMS-LaTe

Synthesis of polyethers of hexafluorobenzene and hexafluoropentanediol

Two new polyethers, poly /hexafluoropentamethylene tetrafluoro-p-phenylene ether/ and a completely hydroxyl-terminated polyether, is prepared by reactions of hexafluorobenzene with hexafluoropentanediol. The polyethers can be prepared as low molecular weight oils, as intermediate molecular weight waxes, or as high molecular weight elastomers

Linearly edge-reinforced random walks

We review results on linearly edge-reinforced random walks. On finite graphs, the process has the same distribution as a mixture of reversible Markov chains. This has applications in Bayesian statistics and it has been used in studying the random walk on infinite graphs. On trees, one has a representation as a random walk in an independent random environment. We review recent results for the random walk on ladders: recurrence, a representation as a random walk in a random environment, and estimates for the position of the random walker.Comment: Published at http://dx.doi.org/10.1214/074921706000000103 in the IMS Lecture Notes--Monograph Series (http://www.imstat.org/publications/lecnotes.htm) by the Institute of Mathematical Statistics (http://www.imstat.org

The Current State of Normative Agent-Based Systems

Recent years have seen an increase in the application of ideas from the social sciences to computational systems. Nowhere has this been more pronounced than in the domain of multiagent systems. Because multiagent systems are composed of multiple individual agents interacting with each other many parallels can be drawn to human and animal societies. One of the main challenges currently faced in multiagent systems research is that of social control. In particular, how can open multiagent systems be configured and organized given their constantly changing structure? One leading solution is to employ the use of social norms. In human societies, social norms are essential to regulation, coordination, and cooperation. The current trend of thinking is that these same principles can be applied to agent societies, of which multiagent systems are one type. In this article, we provide an introduction to and present a holistic viewpoint of the state of normative computing (computational solutions that employ ideas based on social norms.) To accomplish this, we (1) introduce social norms and their application to agent-based systems; (2) identify and describe a normative process abstracted from the existing research; and (3) discuss future directions for research in normative multiagent computing. The intent of this paper is to introduce new researchers to the ideas that underlie normative computing and survey the existing state of the art, as well as provide direction for future research.Norms, Normative Agents, Agents, Agent-Based System, Agent-Based Simulation, Agent-Based Modeling

Possible loss and recovery of Gibbsianness during the stochastic evolution of Gibbs measures

We consider Ising-spin systems starting from an initial Gibbs measure $\nu$ and evolving under a spin-flip dynamics towards a reversible Gibbs measure $\mu\not=\nu$. Both $\nu$ and $\mu$ are assumed to have a finite-range interaction. We study the Gibbsian character of the measure $\nu S(t)$ at time $t$ and show the following: (1) For all $\nu$ and $\mu$, $\nu S(t)$ is Gibbs for small $t$. (2) If both $\nu$ and $\mu$ have a high or infinite temperature, then $\nu S(t)$ is Gibbs for all $t>0$. (3) If $\nu$ has a low non-zero temperature and a zero magnetic field and $\mu$ has a high or infinite temperature, then $\nu S(t)$ is Gibbs for small $t$ and non-Gibbs for large $t$. (4) If $\nu$ has a low non-zero temperature and a non-zero magnetic field and $\mu$ has a high or infinite temperature, then $\nu S(t)$ is Gibbs for small $t$, non-Gibbs for intermediate $t$, and Gibbs for large $t$. The regime where $\mu$ has a low or zero temperature and $t$ is not small remains open. This regime presumably allows for many different scenarios