Genetics Analysis Workshop 16 Problem 2: tTe Framingham Heart Study Data

Genetic Analysis Workshop 16 (GAW16) Problem 2 presented data from the Framingham Heart Study (FHS), an observational, prospective study of risk factors for cardiovascular disease begun in 1948. Data have been collected in three generations of family participants in the study and the data presented for GAW16 included phenotype data from all three generations, with four examinations of data collected repeatedly for the first two generations. The trait data consisted of information on blood pressure, hypertension treatment, lipid levels, diabetes and blood glucose, smoking, alcohol consumed, weight, and coronary heart disease incidence. Additionally, genotype data obtained through a genome-wide scan (FHS SHARe) of 550,000 single-nucleotide polymorphisms from Affymetrix chips were included with the GAW16 data. The genotype data were also used for GAW16 Problem 3, where simulated phenotypes were generated using the actual FHS genotypes. These data served to provide investigators with a rich resource to study the behavior of genome-wide scans with longitudinally collected family data and to develop and apply new procedures.National Heart, Lung and Blood Institute (2 N01-HC-25195-06); National Institutes of Health (National Institute of General Medical Sciences R01 GM031575

The European Arrest Warrant: the role of judges when human rights are at risk

This article examines the role of the judiciary in protecting fundamental rights in European extradition cases, in particular the impact of the European Court of Human Rights' decision in Mss v Belgium and Greece

Detained without trial: Fair Trials International‟s response to the European Commission‟s Green Paper on detention

The report presents the case studies of 11 individuals whose rights were infringed due to excessive and unjustified pre-trial detention. The report analyses the pre-trial detention regimes of 15 EU Member States: the Czech Republic, France, England and Wales, Germany, Greece, Ireland, Italy, Luxembourg, the Netherlands, Poland, Portugal, Romania, Slovakia, Spain and Sweden. Key statistical data on rates of pre-trial detention in these and other EU countries are presented in Appendix 1. The report was submitted to the European Commission in response to its Green Paper on detention issued in 2010

Expanding Universe Illusion

We present a new induced movement illusion from global expansion or contraction in a triangular region filled with rising or falling textures. Objective global expansion or contraction induces lateral movement in the oblique edges of the triangle. The effects may be due to common and relative movements operating within a single texture

Genome-Wide Association to Body Mass Index and Waist Circumference: The Framingham Heart Study 100K Project

BACKGROUND: Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures of adiposity in the Framingham Heart Study. METHODS: A total of 1341 Framingham Heart Study participants in 310 families genotyped with the Affymetrix 100K SNP GeneChip had adiposity traits measured over 30 years of follow up. Body mass index (BMI), waist circumference (WC), weight change, height, and radiographic measures of adiposity (subcutaneous adipose tissue, visceral adipose tissue, waist circumference, sagittal height) were measured at multiple examination cycles. Multivariable-adjusted residuals, adjusting for age, age-squared, sex, smoking, and menopausal status, were evaluated in association with the genotype data using additive Generalized Estimating Equations (GEE) and Family Based Association Test (FBAT) models. We prioritized mean BMI over offspring examinations (1–7) and cohort examinations (10, 16, 18, 20, 22, 24, 26) and mean WC over offspring examinations (4–7) for presentation. We evaluated associations with 70,987 SNPs on autosomes with minor allele frequencies of at least 0.10, Hardy-Weinberg equilibrium p ≥ 0.001, and call rates of at least 80%. RESULTS: The top SNPs to be associated with mean BMI and mean WC by GEE were rs110683 (p-value 1.22*10-7) and rs4471028 (p-values 1.96*10-7). Please see for the complete set of results. We were able to validate SNPs in known genes that have been related to BMI or other adiposity traits, including the ESR1 Xba1 SNP, PPARG, and ADIPOQ. CONCLUSION: Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.National Heart, Lung, and Blood Institute's Framingham Heart Study (N01-HC-25195); Atwood (R01 DK066241); National Institutes of Health National Center for Research Resources Shared Instrumentation grant (1S10RR163736-01A1

Angular dependence of domain wall resistivity in artificial magnetic domain structures

We exploit the ability to precisely control the magnetic domain structure of perpendicularly magnetized Pt/Co/Pt trilayers to fabricate artificial domain wall arrays and study their transport properties. The scaling behaviour of this model system confirms the intrinsic domain wall origin of the magnetoresistance, and systematic studies using domains patterned at various angles to the current flow are excellently described by an angular-dependent resistivity tensor containing perpendicular and parallel domain wall resistivities. We find that the latter are fully consistent with Levy-Zhang theory, which allows us to estimate the ratio of minority to majority spin carrier resistivities, rho-down/rho-up~5.5, in good agreement with thin film band structure calculations.Comment: 14 pages, 3 figure

A new method for atmospheric detection of the CH3O2 radical

A new method for measurement of the methyl peroxy (CH3O2) radical has been developed using the conversion of CH3O2 into CH3O by excess NO with subsequent detection of CH3O by fluorescence assay by gas expansion (FAGE) with laser excitation at ca. 298 nm. The method can also directly detect CH3O, when no nitric oxide is added. Laboratory calibrations were performed to characterise the FAGE instrument sensitivity using the conventional radical source employed in OH calibration with conversion of a known concentration of OH into CH3O2 via reaction with CH4 in the presence of O2. Detection limits of 3.8 × 108 and 3.0 × 108 molecule cm−3 were determined for CH3O2 and CH3O respectively for a signal-to-noise ratio of 2 and 5 min averaging time. Averaging over 1 h reduces the detection limit for CH3O2 to 1.1 × 108 molecule cm−3, which is comparable to atmospheric concentrations. The kinetics of the second-order decay of CH3O2 via its self-reaction were observed in HIRAC (Highly Instrumented Reactor for Atmospheric Chemistry) at 295 K and 1 bar and used as an alternative method of calibration to obtain a calibration constant with overlapping error limits at the 1σ level with the result of the conventional method of calibration. The overall uncertainties of the two methods of calibrations are similar – 15 % for the kinetic method and 17 % for the conventional method – and are discussed in detail. The capability to quantitatively measure CH3O in chamber experiments is demonstrated via observation in HIRAC of CH3O formed as a product of the CH3O2 self-reaction

First Report of the Alfalfa Blotch Leafminer (Diptera: Agromyzidae), and Selected Parasites (Hymenoptera: Eulophidae) in Minnesota and Wisconsin, USA

Alfalfa blotch leafminer, Agromyza frontella, has been a serious pest of alfalfa, Medicago sativa, in the northeastern U.S. and in eastern Ontario, Canada. Until recently, the western edge of the A. frontella distribution in the U.S. was limited to eastern Ohio. We document for the first time, the occurrence of A. frontella in Minnesota and Wisconsin. Alfalfa stems damaged by A. frontella, based on adult feeding punctures, obvious blotched leafmining or the presence of larvae, were first found in 3 northern Minnesota coun­ties during October, 1994. Infested counties included Lake of the Woods, Cook and Lake, all bordering western Ontario, Canada. In 1995, A. frontella was again found in Cook and Lake counties, where 99-100% of the stems, and 18-35% of the trifoliates/stem, contained larvae or exhibited obvious feeding damage. In 1996, following a more expanded survey, a total of 11 and 5 counties, in Minnesota and Wisconsin, respectively, showed some level of A. frontella feeding damage (stem samples ranged from \u3c5 to 100% infested). Based on additional counties surveyed 11 October, 1996, where A. frontella was not found, we now have a reasonable estimate of the southern edge of the distribution in Minnesota and Wisconsin. A total of 2 and 6 A. frontella adults were identified from sweep-net samples taken from fields with obvious feeding damage during 1995 (Lake Co.) and 1996 (Cook Co,), respectively. Three eulophid (Hymenoptera) parasites were reared from A. frontella-infested alfalfa stems collected during October, 1994 in Cook Co., Minn., including: Diglyphus begini, D. pulchripes, and Diglyphus sp., prob. isaea, all of which are new records. Our hypothesis is that A. frontella moved into Minnesota from Ontario Canada, via alfalfa hay purchased by northern Minnesota growers