Economic Doctrines and Approaches to Climate Change Policy

In climate change, as in all policy issues, economic philosophy has a significant influence on how people view both the problems and the solutions. For the first time, ITIF surveys four dominant schools of economic thought and analyzes how adherents approach policy options for climate change and energy policy. With climate change and major energy legislation stalled, maybe it is time to put aside fixed philosophical notions and take a practical look on ways to address climate change in an economically feasible way. The report reviews the principles and goals of each economic doctrine, and offers a critique of the advantages and limitations of each doctrine's contribution to addressing the challenge of climate change.Innovation; Economics; Climate Change; Public Policy

User's guide for CCT2WA (converting CCT's to work-addressable file)

The CCT2WA program, developed to convert the shuttle post-flight computer compatible tape data to a word addressable mass storage file, is described. The use of utility processors that can be used to copy word addressable files from mass storage to mass storage is also described

Partnering to Enhance Education and Public Engagement Programs

Collaborating with partners is a fundamental aspect of the Lunar and Planetary Institute's (LPI) educational and public engagement efforts. Such partnerships enable scientists and educators to include members of the audience in program planning and execution. Ultimately, partnerships strengthen programs by providing diverse resources, expertise, and expanding the potential audience

Economic Doctrines and Approaches to Climate Change Policy

In climate change, as in all policy issues, economic philosophy has a significant influence on how people view both the problems and the solutions. For the first time, ITIF surveys four dominant schools of economic thought and analyzes how adherents approach policy options for climate change and energy policy. With climate change and major energy legislation stalled, maybe it is time to put aside fixed philosophical notions and take a practical look on ways to address climate change in an economically feasible way. The report reviews the principles and goals of each economic doctrine, and offers a critique of the advantages and limitations of each doctrine's contribution to addressing the challenge of climate change

Economic Doctrines and Approaches to Climate Change Policy

In climate change, as in all policy issues, economic philosophy has a significant influence on how people view both the problems and the solutions. For the first time, ITIF surveys four dominant schools of economic thought and analyzes how adherents approach policy options for climate change and energy policy. With climate change and major energy legislation stalled, maybe it is time to put aside fixed philosophical notions and take a practical look on ways to address climate change in an economically feasible way. The report reviews the principles and goals of each economic doctrine, and offers a critique of the advantages and limitations of each doctrine's contribution to addressing the challenge of climate change

I Feel Like He\u27s Looking in the Computer World to be Social, But I Can\u27t Trust His Judgement : Reimagining Parental Control for Children With ASD

Children with Autism Spectrum Disorder (ASD) often seek comfort from devices (e.g., smartphones) to deal with social overstimulation. However, such reliance exposes them to inappropriate digital content and increases susceptibility to mimicry and social vulnerability. Thus, parents having children with ASD encounter unique challenges in regulating their device usage, which are little addressed in the existing literature on parental mediation. As we begin to address this gap, we designed low-fidelity prototypes centered around open communication and self-regulation, which we refined based on the feedback from six ASD experts in two focus groups. We evaluated updated designs (presented in the form of storyboards) through semi-structured interviews with 25 parents whose children with ASD (aged below 14) are active Internet users. Our study joins the body of work on parental mediation; our findings provide insights into inclusive parental control tools for children with ASD, and offer guidelines for future research in these directions

Q134R: Small Chemical Compound with NFAT Inhibitory Properties Improves Behavioral Performance and Synapse Function in Mouse Models of Amyloid Pathology

Inhibition of the protein phosphatase calcineurin (CN) ameliorates pathophysiologic and cognitive changes in aging rodents and mice with aging-related Alzheimer\u27s disease (AD)-like pathology. However, concerns over adverse effects have slowed the transition of common CN-inhibiting drugs to the clinic for the treatment of AD and AD-related disorders. Targeting substrates of CN, like the nuclear factor of activated T cells (NFATs), has been suggested as an alternative, safer approach to CN inhibitors. However, small chemical inhibitors of NFATs have only rarely been described. Here, we investigate a newly developed neuroprotective hydroxyquinoline derivative (Q134R) that suppresses NFAT signaling, without inhibiting CN activity. Q134R partially inhibited NFAT activity in primary rat astrocytes, but did not prevent CN-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro. Acute (≤1 week) oral delivery of Q134R to APP/PS1 (12 months old) or wild-type mice (3–4 months old) infused with oligomeric Aβ peptides led to improved Y maze performance. Chronic (≥3 months) oral delivery of Q134R appeared to be safe, and, in fact, promoted survival in wild-type (WT) mice when given for many months beyond middle age. Finally, chronic delivery of Q134R to APP/PS1 mice during the early stages of amyloid pathology (i.e., between 6 and 9 months) tended to reduce signs of glial reactivity, prevented the upregulation of astrocytic NFAT4, and ameliorated deficits in synaptic strength and plasticity, without noticeably altering parenchymal Aβ plaque pathology. The results suggest that Q134R is a promising drug for treating AD and aging-related disorders