3,736 research outputs found
Role of mycobacteria-induced monocyte/macrophage apoptosis in the pathogenesis of human tuberculosis
Superconductivity and Rattling under High Pressure in the beta-Pyrochlore Oxide RbOs2O6
Rattling-induced superconductivity in the beta-pyrochlore oxide RbOs2O6 is
investigated under high pressures up to 6 GPa. Resistivity measurements in a
high-quality single crystal show that the superconducting transition
temperature Tc increases gradually from 6.3 K at ambient pressure to 8.8 K at
3.5 GPa, surprisingly remains almost constant at 8.8 \pm 0.1 K in a wide
pressure range between 3.5 (Po) and 4.8 GPa, and suddenly drops to 6.3 K at Ps
= 4.9 GPa, followed by a gradual decrease with further pressure increase. Two
anomalies in the temperature dependence of the normal-state resistivity are
observed at Po Ps, revealing the presence of two high-pressure
phases corresponding to the changes in Tc. The rattling of the Rb ion inside a
cage made of Os and O atoms may be slightly and seriously modified in these
high-pressure phases that probably have cages of reduced symmetry,
respectively, so that electron-rattler interactions that govern the
superconducting and transport properties of beta-RbOs2O6 are significantly
affected.Comment: arXiv admin note: text overlap with arXiv:1009.035
Peripheral depletion of NK cells and imbalance of the Treg/Th17 axis in idiopathic pulmonary fibrosis patients
The immune response plays an unsettled role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), the contribution of inflammation being controversial as well. Emerging novel T cell sub-populations including regulatory T lymphocytes (Treg) and interleukin (IL)-17 secreting T helper cells (Th17) may exert antithetical actions in this scenario. Phenotype and frequency of circulating immune cell subsets were assessed by multi-parametric flow cytometry in 29 clinically stable IPF patients and 17 healthy controls. The interplay between Treg lymphocytes expressing transforming growth factor (TGF)-β and Th17 cells was also investigated. Proportion and absolute number of natural killer (NK) cells were significantly reduced in IPF patients in comparison with controls (p90%) expressed TGF-β upon stimulation. Interestingly, the frequency of Th17 cells was significantly compromised in IPF patients (p=0.000) leading to an increased TGF-β/IL-17 ratio (4.2±2.3 vs 0.5±0.3 in controls, p=0.000). Depletion of NK and Th17 cells along with a not compromised Treg compartment delineate the existence of an "immune profile" that argue against the recent hypothesis of IPF as an autoimmune disease. Our findings along with the imbalance of the Treg/Th17 axis more closely suggest these immune perturbations to be similar to those observed in cancer. Clinical relevance, limitations and perspectives for future research are discussed. © 2014 Elsevier Ltd
Procedure for short-lived particle detection in the OPERA experiment and its application to charm decays
The OPERA experiment, designed to perform the first observation of oscillations in appearance mode through the detection of
the leptons produced in charged current interactions, has
collected data from 2008 to 2012. In the present paper, the procedure developed
to detect particle decays, occurring over distances of the order of 1 mm
from the neutrino interaction point, is described in detail. The results of its
application to the search for charmed hadrons are then presented as a
validation of the methods for appearance detection
Phonon Dynamics and Multipolar Isomorphic Transition in beta-pyrochlore KOs2O6
We investigate with a microscopic model anharmonic K-cation oscillation
observed by neutron experiments in beta-pyrochlore superconductor KOs2O6, which
also shows a mysterious first-order structural transition at Tp=7.5 K. We have
identified a set of microscopic model parameters that successfully reproduce
the observed temperature dependence and the superconducting transition
temperature. Considering changes in the parameters at Tp, we can explain
puzzling experimental results about electron-phonon coupling and neutron data.
Our analysis demonstrates that the first-order transition is multipolar
transition driven by the octupolar component of K-cation oscillations. The
octupole moment does not change the symmetry and is characteristic to
noncentrosymmetric K-cation potential.Comment: 5 pages, 4 figures, submitted to J. Phys. Soc. Jp
A facility to Search for Hidden Particles (SHiP) at the CERN SPS
A new general purpose fixed target facility is proposed at the CERN SPS
accelerator which is aimed at exploring the domain of hidden particles and make
measurements with tau neutrinos. Hidden particles are predicted by a large
number of models beyond the Standard Model. The high intensity of the SPS
400~GeV beam allows probing a wide variety of models containing light
long-lived exotic particles with masses below (10)~GeV/c,
including very weakly interacting low-energy SUSY states. The experimental
programme of the proposed facility is capable of being extended in the future,
e.g. to include direct searches for Dark Matter and Lepton Flavour Violation.Comment: Technical Proposa
Determination of the muon charge sign with the dipolar spectrometers of the OPERA experiment
The OPERA long-baseline neutrino-oscillation experiment has observed the
direct appearance of in the CNGS beam. Two large muon
magnetic spectrometers are used to identify muons produced in the
leptonic decay and in interactions by measuring their charge and
momentum. Besides the kinematic analysis of the decays, background
resulting from the decay of charmed particles produced in
interactions is reduced by efficiently identifying the muon track. A new method
for the charge sign determination has been applied, via a weighted angular
matching of the straight track-segments reconstructed in the different parts of
the dipole magnets. Results obtained for Monte Carlo and real data are
presented. Comparison with a method where no matching is used shows a
significant reduction of up to 40\% of the fraction of wrongly determined
charges.Comment: 10 pages. Improvements in the tex
Observation of nu_tau appearance in the CNGS beam with the OPERA experiment
The OPERA experiment is searching for nu_mu -> nu_tau oscillations in
appearance mode i.e. via the direct detection of tau leptons in nu_tau charged
current interactions. The evidence of nu_mu -> nu_tau appearance has been
previously reported with three nu_tau candidate events using a sub-sample of
data from the 2008-2012 runs. We report here a fourth nu_tau candidate event,
with the tau decaying into a hadron, found after adding the 2012 run events
without any muon in the final state to the data sample. Given the number of
analysed events and the low background, nu_mu -> nu_tau oscillations are
established with a significance of 4.2sigma.Comment: Submitted to Progress of Theoretical and Experimental Physics (PTEP
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