2,848 research outputs found
Design of a low cost earth resources system
The author has identified the following significant results. Survey results indicated that users of remote sensing data in the Southeastern U.S. were increasingly turning to digital processing techniques. All the states surveyed have had some involvement in projects using digitally processed data. Even those states which do not yet have in-house capabilities for digital processing were extremely interested in and were planning to develop such capabilities
Computer processing of peach tree decline data
There are no author-identified significant results in this report
Development of large-internal-surface-area nickel-metal plaques third quarterly progress report, dec. 19, 1964 - mar. 18, 1965
Electrodes impregnated with cadmium for porosity and electrochemical evaluatio
Non-malleable codes for space-bounded tampering
Non-malleable codes—introduced by Dziembowski, Pietrzak and Wichs at ICS 2010—are key-less coding schemes in which mauling attempts to an encoding of a given message, w.r.t. some class of tampering adversaries, result in a decoded value that is either identical or unrelated to the original message. Such codes are very useful for protecting arbitrary cryptographic primitives against tampering attacks against the memory. Clearly, non-malleability is hopeless if the class of tampering adversaries includes the decoding and encoding algorithm. To circumvent this obstacle, the majority of past research focused on designing non-malleable codes for various tampering classes, albeit assuming that the adversary is unable to decode. Nonetheless, in many concrete settings, this assumption is not realistic
Development of large-internal-surface-area nickel-metal plaques Final report, Jun. 18, 1964 - Sep. 30, 1965
Large internal surface area porous nickel metal plaques for rechargeable cadmium electrodes to improve nickel-cadmium batterie
Density effect in Cu K-shell ionization by 5.1-GeV electrons
We have made an absolute measurement of the Cu K-shell impact ionization cross section by 5.1-GeV electrons, which demonstrates directly a density effect predicted by Fermi in 1940. By determining the ratio of the K x-ray yield from a thin front and back layer of the target by a novel grazing emission method, we have verified the effect of transition radiation on the x-ray production, suggested by Sorensen and reported by Bak et al
Intersections of Competencies for Practice and Research in Community Psychology
The Community Psychology Practice Competencies (Dalton & Wolfe, 2012) have helped the field of community psychology clarify the skills necessary to engage in community practice in our discipline and have begun to be used for designing curricula and other educational tools in community psychology training programs. Many community psychologists, however, combine elements of both practice and research in their work, and research skills are less represented in the practice competencies than other types of skills. Society for Community Research and Action’s Council on Education recently developed a set of Community Psychology Research Competencies to provide additional depth of understanding of the types of skills and knowledge associated with rigorous and impactful research in community psychology. This paper describes the research competencies and their development and considers them in the context of the existing practice competencies in the interests of expanding the understanding of how research and practice intersect in our training programs and our work in both academic and non-academic settings. An action-research cycle model is presented to help explain how practice and research competencies complement one another and how both are informed by a common set of principles guiding all the activities of our field. Recommendations are then offered for integrating the research and practice competencies across practice- or research-focused training programs
Intersections of Competencies for Practice and Research in Community Psychology
The Community Psychology Practice Competencies (Dalton & Wolfe, 2012) have helped the field of community psychology clarify the skills necessary to engage in community practice in our discipline and have begun to be used for designing curricula and other educational tools in community psychology training programs. Many community psychologists, however, combine elements of both practice and research in their work, and research skills are less represented in the practice competencies than other types of skills. Society for Community Research and Action’s Council on Education recently developed a set of Community Psychology Research Competencies to provide additional depth of understanding of the types of skills and knowledge associated with rigorous and impactful research in community psychology. This paper describes the research competencies and their development and considers them in the context of the existing practice competencies in the interests of expanding the understanding of how research and practice intersect in our training programs and our work in both academic and non-academic settings. An action-research cycle model is presented to help explain how practice and research competencies complement one another and how both are informed by a common set of principles guiding all the activities of our field. Recommendations are then offered for integrating the research and practice competencies across practice- or research-focused training programs
Cephalosporin-3’-diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of non-typeable Haemophilus influenzae biofilms
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Objectives: PYRRO-C3D is a cephalosporin-3-diazeniumdiolate nitric oxide (NO)-donor prodrug designed to selectively deliver NO to bacterial infection sites. The objective of this study was to assess the activity of PYRRO-C3D against non-typeable Haemophilus influenzae (NTHi) biofilms and examine the role of NO in reducing biofilm-associated antibiotic tolerance.
Methods: The activity of PYRRO-C3D on in vitro NTHi biofilms was assessed through CFU enumeration and confocal microscopy. NO release measurements were performed using an ISO-NO probe. NTHi biofilms grown on primary ciliated respiratory epithelia at an air-liquid interface were used to investigate the effects of PYRRO-C3D in the presence of host tissue. Label-free LC/MS proteomic analyses were performed to identify differentially expressed proteins following NO treatment.
Results: PYRRO-C3D specifically released NO in the presence of NTHi, while no evidence of spontaneous NO release was observed when the compound was exposed to primary epithelial cells. NTHi lacking β-lactamase activity failed to trigger NO release. Treatment significantly increased the susceptibility of in vitro NTHi biofilms to azithromycin, causing a log-fold reduction in viability (p<0.05) relative to azithromycin alone. The response was more pronounced for biofilms grown on primary respiratory epithelia, where a 2-log reduction was observed (p<0.01). Label-free proteomics showed that NO increased expression of sixteen proteins involved in metabolic and transcriptional/translational functions.
Conclusions: NO release from PYRRO-C3D enhances the efficacy of azithromycin against NTHi biofilms, putatively via modulation of NTHi metabolic activity. Adjunctive therapy with NO mediated through PYRRO-C3D represents a promising approach for reducing biofilm associated antibiotic tolerance
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