On the properties of steady states in turbulent axisymmetric flows

We experimentally study the properties of mean and most probable velocity fields in a turbulent von K\'arm\'an flow. These fields are found to be described by two families of functions, as predicted by a recent statistical mechanics study of 3D axisymmetric flows. We show that these functions depend on the viscosity and on the forcing. Furthermore, when the Reynolds number is increased, we exhibit a tendency for Beltramization of the flow, i.e. a velocity-vorticity alignment. This result provides a first experimental evidence of nonlinearity depletion in non-homogeneous non-isotropic turbulent flow.Comment: latex prl-stationary-051215arxiv.tex, 9 files, 6 figures, 4 pages (http://www-drecam.cea.fr/spec/articles/S06/008/

Mild acetabular dysplasia and risk of osteoarthritis of the hip : a case-control study

Objective To determine whether mild variation in acetabular depth (AD) and shape is a risk factor for osteoarthritis (OA) of the hip. Methods The unaffected contralateral hip of patients with unilateral hip OA was compared with hips of asymptomatic controls without hip OA, derived from the Nottingham Genetics Osteoarthritis and Lifestyle case–control study. Standardised anteroposterior x-rays of the pelvis were used to measure centre edge (CE) angle and AD. Cut-off points for narrow CE angle and shallow AD were calculated from the control group (mean −1.96×SD). The relative risk of hip OA associated with each feature was estimated using OR and 95% CI and adjusted risks were calculated by logistic regression. Results In controls, both the CE angle and the AD were lower in the left hip than in the right hip. The CE angle related to age in both hips, and AD of the right hip was lower in men than in women. The contralateral unaffected hip in patients with unilateral hip OA had a decreased CE angle and AD compared with controls, irrespective of side. The lowest tertile of the CE angle in contralateral hips was associated with an eightfold risk of OA (aOR 8.06, 95% CI 4.87 to 13.35) and the lowest tertile of AD was associated with a 2.5-fold risk of OA (aOR 2.53, 95% CI 1.28 to 5.00). Significant increases in the risk of OA were also found as the CE angle and AD decreased

Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae

© 2019 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and pain flares are discrete entities. Methods: People from the Early RA Network (ERAN) cohort were assessed annually up to 11 years after presentation (n = 719, 3703 person-years of follow up). Flare events were defined in 2 different ways that were analysed in parallel; DAS28 or Pain Flares. DAS28 Flares satisfied OMERACT flare criteria of increases in DAS28 since the previous assessment (≥1.2 points if active RA or ≥ 0.6 points if inactive RA). A ≥ 4.8-point worsening of SF36-Bodily Pain score defined Pain Flares. The first documented episode of each of DAS28 and Pain Flare in each person was analysed. Subgroups within DAS28 and Pain Flares were determined using Latent Class Analysis. Clinical course was compared between flare subgroups. Results: DAS28 (45%) and Pain Flares (52%) were each common but usually discordant, with 60% of participants in DAS28 Flare not concurrently in Pain Flare, and 64% of those in Pain Flare not concurrently in DAS28 Flare. Three discrete DAS28 Flare subgroups were identified. One was characterised by increases in tender/swollen joint counts (14.4%), a second by increases in symptoms (13.1%), and a third displayed lower flare severity (72.5%). Two discrete Pain Flare subgroups were identified. One occurred following low disease activity and symptoms (88.6%), and the other occurred on the background of ongoing active disease and pain (11.4%). Despite the observed differences between DAS28 and Pain Flares, each was associated with increased disability which persisted beyond the flare episode. Conclusion: Flares are both common and heterogeneous in people with RA. Furthermore our findings indicate that for some patients there is a discordance between inflammation and pain in flare events. This discrete flare subgroups might reflect different underlying inflammation and pain mechanisms. Treatments addressing different mechanisms might be required to reduce persistent disability after DAS28 and Pain Flares.Peer reviewedFinal Published versio

Seasonal and Interspecific Variation in Frugivory by a Mixed Resident-Migrant Overwintering Songbird Community

Many temperate passerine bird species switch from diets of mostly invertebrates in the spring and summer to diets that include fruit and seeds in the fall and winter. However, relatively few studies have quantified diet composition or the extent of seasonal shifts during the non-breeding period, particularly among species and across communities with both residents and migrants. We measured carbon and nitrogen stable isotope values in food items (fruits, C3 and C4seeds, and insects from various trophic levels and plant communities) and in multiple tissues (feathers and plasma/whole blood) from 11 species of songbirds wintering in the southeastern U.S. We combined these diet and tissue values with empirically derived discrimination factors and used concentration-dependent mixing models to quantify seasonal diet shifts. We also validated mixing model results with data from fecal samples. Diets in this bird community, as delineated N and C isotopic space, diverged in the fall and winter relative to the summer as consumption of fruits and seeds increased. Across this songbird community, estimated contributions of fruit to plasma/whole blood increased from 16.2 ± 7.5% in the fall (mean ± SD; range: 4–26%) to 21.7 ± 10.3% (range: 9–37%) in the winter, while contributions of seeds increased from 29.4 ± 2.6% (range: 28–32%) in the fall to 36.6 ± 4.8% (range: 32–42%) in the winter. Fecal data showed qualitatively similar trends to mixing models, but consistently estimated higher contributions of fruit. Our work indicates that fruits and seeds constitute substantial sources of sustenance for non-breeding songbirds, there is considerable separation of resource use among species in the fall and winter, and fecal estimates of contributions to songbird tissues should be interpreted cautiously

Binary Black Hole Mergers in the First Advanced LIGO Observing Run

The first observational run of the Advanced LIGO detectors, from September 12, 2015 to January 19, 2016, saw the first detections of gravitational waves from binary black hole mergers. In this paper, we present full results from a search for binary black hole merger signals with total masses up to 100M⊙ and detailed implications from our observations of these systems. Our search, based on general-relativistic models of gravitational-wave signals from binary black hole systems, unambiguously identified two signals, GW150914 and GW151226, with a significance of greater than 5σ over the observing period. It also identified a third possible signal, LVT151012, with substantially lower significance and with an 87% probability of being of astrophysical origin. We provide detailed estimates of the parameters of the observed systems. Both GW150914 and GW151226 provide an unprecedented opportunity to study the two-body motion of a compact-object binary in the large velocity, highly nonlinear regime. We do not observe any deviations from general relativity, and we place improved empirical bounds on several highorder post-Newtonian coefficients. From our observations, we infer stellar-mass binary black hole merger rates lying in the range 9–240 Gpc−3 yr−1. These observations are beginning to inform astrophysical predictions of binary black hole formation rates and indicate that future observing runs of the Advanced detector network will yield many more gravitational-wave detections

Turbulent dissipation in the ISM: the coexistence of forced and decaying regimes and implications for galaxy formation and evolution

We discuss the dissipation of turbulent kinetic energy Ek in the global ISM by means of 2-D, MHD, non-isothermal simulations in the presence of model radiative heating and cooling. We argue that dissipation in 2D is representative of that in three dimensions as long as it is dominated by shocks rather than by a turbulent cascade. Energy is injected at a few isolated sites in space, over relatively small scales, and over short time periods. This leads to the coexistence of forced and decaying regimes in the same flow. We find that the ISM-like flow dissipates its turbulent energy rapidly. In simulations with forcing, the input parameters are the radius l_f of the forcing region, the total kinetic energy e_k each source deposits into the flow, and the rate of formation of those regions, sfr_OB. The global dissipation time t_d depends mainly on l_f. In terms of measurable properties of the ISM, t_d >= Sigma_g u_rms^2/(e_k sfr_OB), where Sigma_g is the average gas surface density and u_rms is the rms velocity dispersion. For the solar neighborhood, t_d >= 1.5x10^7 yr. The global dissipation time is consistently smaller than the crossing time of the largest energy-containing scales. In decaying simulations, Ek decreases with time as t^-n, where n~0.8-0.9. This suggests a decay with distance d as Ek\propto d^{-2n/(2-n)} in the mixed forced+decaying case. If applicable to the vertical direction, our results support models of galaxy evolution in which stellar energy injection provides significant support for the gas disk thickness, but not models of galaxy formation in which this energy injection is supposed to reheat an intra-halo medium at distances of up to 10-20 times the optical galaxy size, as the dissipation occurs on distances comparable to the disk height.Comment: 23 pages, including figures. To appear in ApJ. Abstract abridge

Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine

Cladribine tablets are a treatment for multiple sclerosis with effects on lymphocytes, yet its mode of action has not been fully established. Here, we analyzed the effects of cladribine on mitochondrial DNA integrity in lymphocytes. We treated cultured human T-cell lines (CCRF-CEM and Jurkat) with varying concentrations of cladribine to mimic the slow cell depletion observed in treated patients. The CCRF-CEM was more susceptible to cladribine than Jurkat cells. In both cells, mitochondrial protein synthesis, mitochondrial DNA copy number, and mitochondrial cytochrome-c oxidase-I mRNA mutagenesis was not affected by cladribine, while caspase-3 cleavage was detected in Jurkat cells at 100 nM concentration. Cladribine treatment at concentrations up to 10 nM in CCRF-CEM and 100 nM in Jurkat cells did not induce significant increase in mitochondrial DNA mutations. Peripheral blood mononuclear cells from eight multiple sclerosis patients and four controls were cultured with or without an effective dose of cladribine (5 nM). However, we did not find any differences in mitochondrial DNA somatic mutations in lymphocyte subpopulations (CD4+, CD8+, and CD19+) between treated versus nontreated cells. The overall mutation rate was similar in patients and controls. When different lymphocyte subpopulations were compared, greater mitochondrial DNA mutation levels were detected in CD8+ (P = 0.014) and CD4+ (P = 0.038) as compared to CD19+ cells, these differences were independent of cladribine treatment. We conclude that T cells have more detectable mitochondrial DNA mutations than B cells, and cladribine has no detectable mutagenic effect on lymphocyte mitochondrial genome nor does it impair mitochondrial function in human T-cell lines

Coherent Bayesian analysis of inspiral signals

We present in this paper a Bayesian parameter estimation method for the analysis of interferometric gravitational wave observations of an inspiral of binary compact objects using data recorded simultaneously by a network of several interferometers at different sites. We consider neutron star or black hole inspirals that are modeled to 3.5 post-Newtonian (PN) order in phase and 2.5 PN in amplitude. Inference is facilitated using Markov chain Monte Carlo methods that are adapted in order to efficiently explore the particular parameter space. Examples are shown to illustrate how and what information about the different parameters can be derived from the data. This study uses simulated signals and data with noise characteristics that are assumed to be defined by the LIGO and Virgo detectors operating at their design sensitivities. Nine parameters are estimated, including those associated with the binary system, plus its location on the sky. We explain how this technique will be part of a detection pipeline for binary systems of compact objects with masses up to 20 \sunmass, including cases where the ratio of the individual masses can be extreme.Comment: Accepted for publication in Classical and Quantum Gravity, Special issue for GWDAW-1

Fluctuation dynamo and turbulent induction at low magnetic Prandtl numbers

This paper is a detailed report on a programme of simulations used to settle a long-standing issue in the dynamo theory and demonstrate that the fluctuation dynamo exists in the limit of large magnetic Reynolds number Rm>>1 and small magnetic Prandtl number Pm<<1. The dependence of the critical Rm_c vs. the hydrodynamic Reynolds number Re is obtained for 1<Re<6700. In the limit Pm<<1, Rm_c is ~3 times larger than for Pm>1. The stability curve Rm_c(Re) (and, it is argued, the nature of the dynamo) is substantially different from the case of the simulations and liquid-metal experiments with a mean flow. It is not as yet possible to determine numerically whether the growth rate is ~Rm^{1/2} in the limit Re>>Rm>>1, as should be the case if the dynamo is driven by the inertial-range motions. The magnetic-energy spectrum in the low-Pm regime is qualitatively different from the Pm>1 case and appears to develop a negative spectral slope, although current resolutions are insufficient to determine its asymptotic form. At 1<Rm<Rm_c, the magnetic fluctuations induced via the tangling by turbulence of a weak mean field are investigated and the possibility of a k^{-1} spectrum above the resistive scale is examined. At low Rm<1, the induced fluctuations are well described by the quasistatic approximation; the k^{-11/3} spectrum is confirmed for the first time in direct numerical simulations.Comment: IoP latex, 27 pages, 25 figures, 3 tables. Accepted by New J. Physic