2,943 research outputs found
Investigation of the feasibility of sterile assembly of silver-zinc batteries
Electrical performance, bioassays, and packaging concepts evaluated in sterile assembly of silver zinc batterie
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.
Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons and oligodendrocyte progenitors (NG2(+) cells) exhibit enhanced proliferation and differentiation, although the cause of these changes in oligodendroglia is unknown. We found extensive degeneration of gray matter oligodendrocytes in the spinal cord of SOD1 (G93A) ALS mice prior to disease onset. Although new oligodendrocytes were formed, they failed to mature, resulting in progressive demyelination. Oligodendrocyte dysfunction was also prevalent in human ALS, as gray matter demyelination and reactive changes in NG2(+) cells were observed in motor cortex and spinal cord of ALS patients. Selective removal of mutant SOD1 from oligodendroglia substantially delayed disease onset and prolonged survival in ALS mice, suggesting that ALS-linked genes enhance the vulnerability of motor neurons and accelerate disease by directly impairing the function of oligodendrocytes
On Writ of Certiorari to the United States Court of Appeals for the Ninth Circuit, Brief of Product Liability Advisory Council, Inc., National Association of Manufacturers, Business Roundtable, and Chemical Manufacturers Association as Amici Curiae in Support of Respondent, William Daubert and Joyce Daubert, Individually and as Guardians Ad Litem for Jason Daubert, and Anita De Young, Individually and as Gaurdian Ad Litem for Eric Schuller v. Merrell Dow Pharmaceuticals, Inc.
The Federal Rules of Evidence exclude expert scientific testimony when it has been developed without regard for accepted scientific methods.
This case focuses on expert scientific evidence. Such evidence plays a vital and often dispositive role in modern litigation. For scientific evidence to be helpful to the factfinder it must meet some minimal threshold of reliability. To hold otherwise would be to allow a system of adjudication based more on chance than on reason
New Upper Limits on the Tau Neutrino Mass from Primordial Helium Considerations
In this paper we reconsider recently derived bounds on tau neutrinos,
taking into account previously unaccounted for effects. We find that, assuming
that the neutrino life-time is longer than , the constraint
rules out masses in the range
for Majorana neutrinos and
for Dirac neutrinos. Given that the present
laboratory bound is 35 MeV, our results lower the present bound to and
for Majorana and Dirac neutrinos respectively.Comment: 9 pages (2 figures available upon request), UM-AC-93-0
Next to leading order spin-orbit effects in the motion of inspiralling compact binaries
Using effective field theory (EFT) techniques we calculate the
next-to-leading order (NLO) spin-orbit contributions to the gravitational
potential of inspiralling compact binaries. We use the covariant spin
supplementarity condition (SSC), and explicitly prove the equivalence with
previous results by Faye et al. in arXiv:gr-qc/0605139. We also show that the
direct application of the Newton-Wigner SSC at the level of the action leads to
the correct dynamics using a canonical (Dirac) algebra. This paper then
completes the calculation of the necessary spin dynamics within the EFT
formalism that will be used in a separate paper to compute the spin
contributions to the energy flux and phase evolution to NLO.Comment: 25 pages, 4 figures, revtex4. v2: minor changes, refs. added. To
appear in Class. Quant. Gra
Casimir effect in de Sitter and Anti-de Sitter braneworlds
We discuss the bulk Casimir effect (effective potential) for a conformal or
massive scalar when the bulk represents five-dimensional AdS or dS space with
two or one four-dimensional dS brane, which may correspond to our universe.
Using zeta-regularization, the interesting conclusion is reached, that for both
bulks in the one-brane limit the effective potential corresponding to the
massive or to the conformal scalar is zero. The radion potential in the
presence of quantum corrections is found. It is demonstrated that both the dS
and the AdS braneworlds may be stabilized by using the Casimir force only. A
brief study indicates that bulk quantum effects are relevant for brane
cosmology, because they do deform the de Sitter brane. They may also provide a
natural mechanism yielding a decrease of the four-dimensional cosmological
constant on the physical brane of the two-brane configuration.Comment: 37 pages, LaTeX, references added, some revision is done, version to
appear in PR
Matched Asymptotic Expansion for Caged Black Holes - Regularization of the Post-Newtonian Order
The "dialogue of multipoles" matched asymptotic expansion for small black
holes in the presence of compact dimensions is extended to the Post-Newtonian
order for arbitrary dimensions. Divergences are identified and are regularized
through the matching constants, a method valid to all orders and known as
Hadamard's partie finie. It is closely related to "subtraction of
self-interaction" and shows similarities with the regularization of quantum
field theories. The black hole's mass and tension (and the "black hole
Archimedes effect") are obtained explicitly at this order, and a Newtonian
derivation for the leading term in the tension is demonstrated. Implications
for the phase diagram are analyzed, finding agreement with numerical results
and extrapolation shows hints for Sorkin's critical dimension - a dimension
where the transition turns second order.Comment: 28 pages, 5 figures. v2:published versio
Ethnomedicine in healthcare systems of the world: a Semester at Sea pilot survey in 11 countries
An understanding and appreciation for the varied healthcare systems in use throughout the world are increasingly vital for medical personnel as patient populations are now composed of ethnically diverse people with wide-ranging belief systems. While not a statistically valid survey, this pilot study gives a global overview of healthcare differences around the world. A pilot study of 459 individuals from 11 different countries around the world was administered by 33 students in the upper division course, People, Pathology, and World Medicine from Semester at Sea, Fall 2007, to ascertain trends in healthcare therapies. Open-ended surveys were conducted in English, through an interpreter, or in the native language. Western hospital use ranked highly for all countries, while ethnomedical therapies were utilized to a lesser degree. Among the findings, mainland China exhibited the greatest overall percentage of ethnomedical therapies, while the island of Hong Kong, the largest use of Western hospitals. The figures and trends from the surveys suggest the importance of understanding diverse cultural healthcare beliefs when treating individuals of different ethnic backgrounds. The study also revealed the increasingly complex and multisystem-based medical treatments being used internationally
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