Adherence in Rheumatoid Arthritis patients assessed with a validated Italian version of the 5-item compliance questionnaire for rheumatology

OBJECTIVES: The 5-item Compliance Questionnaire for Rheumatology (CQR5) proved reliability and validity in respect of identification of patients likely to be high adherers (HAs) to anti-rheumatic treatment, or low adherers (LAs), i.e. taking<80% of their medications correctly. The objective of the study was to validate an Italian version of CQR5 (I-CQR5) in rheumatoid arthritis (RA) patients and to investigate factors associated with high adherence. METHODS: RA patients, undergoing treatment with ≥1 self-administered conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) or biological DMARD (bDMARD), were enrolled. The cross-cultural adaptation and validation of I-CQR5 followed standardised guidelines. I-CQR5 was completed by patients on one occasion. Data were subjected to factor analysis and Partial Credit model Parametrisation (PCM) to assess construct validity of I-CQR5. Analysis of factors associated with high adherence included demographic, social, clinical and treatment information. Factors achieving a p<0.10 in univariate analysis were included in multivariable analysis. RESULTS: Among 604 RA patients, 274 patients were included in the validation and 328 in the analysis of factors associated with adherence. Factor analysis and PCM confirmed the construct validity and consistency of I-CQR5. HAs were found to be 109 (35.2%) of the patients. bDMARD treatment and employment were found to be independently associated with high adherence: OR 2.88 (1.36-6.1), p=0.006 and OR 2.36 (1.21-4.62), p=0.012, respectively. CONCLUSIONS: Only one-third of RA patients were HAs according to I-CQR5. bDMARDs and employment status increased by almost 3-fold the likelihood of being highly adherent to the anti-rheumatic treatment.Peer reviewe

Three-dimensional Ginzburg-Landau simulation of a vortex line displaced by a zigzag of pinning spheres

A vortex line is shaped by a zigzag of pinning centers and we study here how far the stretched vortex line is able to follow this path. The pinning center is described by an insulating sphere of coherence length size such that in its surface the de Gennes boundary condition applies. We calculate the free energy density of this system in the framework of the Ginzburg-Landau theory and study the critical displacement beyond which the vortex line is detached from the pinning center.Comment: Submitted to special issue of Prammna-Journal of Physics devoted to the Vortex State Studie

Shocks in unmagnetized plasma with a shear flow: Stability and magnetic field generation

A pair of curved shocks in a collisionless plasma is examined with a two-dimensional particle-in-cell (PIC) simulation. The shocks are created by the collision of two electron-ion clouds at a speed that exceeds everywhere the threshold speed for shock formation. A variation of the collision speed along the initially planar collision boundary, which is comparable to the ion acoustic speed, yields a curvature of the shock that increases with time. The spatially varying Mach number of the shocks results in a variation of the downstream density in the direction along the shock boundary. This variation is eventually equilibrated by the thermal diffusion of ions. The pair of shocks is stable for tens of inverse ion plasma frequencies. The angle between the mean flow velocity vector of the inflowing upstream plasma and the shock's electrostatic field increases steadily during this time. The disalignment of both vectors gives rise to a rotational electron flow, which yields the growth of magnetic field patches that are coherent over tens of electron skin depths.Comment: 10 pages, 10 figures accepted for publication in Physics of Plasma

Effect of Acute Exercise on Plasma Nitric Oxide Level in Humans

Objective: Since nitric oxide (NO) plays an important role in regulating vascular tone and changes in the plasma concentration of the end product of NO (nitrite/nitrate) have been observed during exercise, we studied the influence of acute exercise on nitrite/nitrate plasma levels in a group of semiprofessional football players and in younger and older sedentary subjects. Methods: The subjects exercised for 10 min on a cycle ergometer and blood samples were obtained at rest and immediately after exercise. Plasma samples were analysed for nitrite/nitrate. Results: The acute physical exercise induced a significant increase in nitrite/nitrate plasma levels both in sedentary and in active subjects. No difference was evident between the younger and older subjects, both in the basal level and after exercise, indicating that the changes could not be due to age. The higher basal plasma level of nitrite/nitrate observed in the active subjects compared with sedentary groups indicates that the state of physical conditioning had an effect on resting NO concentration. Conclusion: It seems that either acute exercise, even for a short time, or training can induce an increase in circulating NO

Plus ça Change? Observing the Dynamics of Morocco's ‘Arab Spring’ in the High Atlas

This contribution focuses on the ‘Arab Spring’ in Morocco and on the interactions between the mainly urban-based activists that made up the 20 February Movement (F20M), and the population in rural areas. Based on six weeks of fieldwork between November 2013 and March 2014, mostly in the areas in and near Marrakech, we find that while the urban F20M events stimulated and inspired protests in rural areas, in practice there were only sporadic contacts based on the activists’ personal feelings of belonging rather than their organizational membership. This is mainly due to discursive disconnects between the centre and periphery. As for the outcomes, in particular the new constitution, many respondents believe that nothing has changed so far

Optimal control technique for Many Body Quantum Systems dynamics

We present an efficient strategy for controlling a vast range of non-integrable quantum many body one-dimensional systems that can be merged with state-of-the-art tensor network simulation methods like the density Matrix Renormalization Group. To demonstrate its potential, we employ it to solve a major issue in current optical-lattice physics with ultra-cold atoms: we show how to reduce by about two orders of magnitudes the time needed to bring a superfluid gas into a Mott insulator state, while suppressing defects by more than one order of magnitude as compared to current experiments [1]. Finally, we show that the optimal pulse is robust against atom number fluctuations.Comment: 5 pages, 4 figures, published versio

A guided search non-dominated sorting genetic algorithm for the multi-objective university course timetabling problem

Copyright @ Springer-Verlag Berlin Heidelberg 2011.The university course timetabling problem is a typical combinatorial optimization problem. This paper tackles the multi-objective university course timetabling problem (MOUCTP) and proposes a guided search non-dominated sorting genetic algorithm to solve the MOUCTP. The proposed algorithm integrates a guided search technique, which uses a memory to store useful information extracted from previous good solutions to guide the generation of new solutions, and two local search schemes to enhance its performance for the MOUCTP. The experimental results based on a set of test problems show that the proposed algorithm is efficient for solving the MOUCTP

The effect of tyre and rider properties on the stability of a bicycle

To work towards an advanced model of the bicycle-rider-environment system, an open-loop bicycle-rider model was developed in the commercial multibody dynamics software ADAMS. The main contribution of this article to bicycle dynamics is the analysis of tyre and rider properties that influence bicycle stability. A system identification method is used to extract linear stability properties from time domain analysis. The weave and capsize eigenmodes of the bicycle-rider system are analysed. The effect of tyre properties is studied using the tyre’s forces and torques that have been measured in several operating conditions. The main result is that extending simplified models with a realistic tyre model leads to a notable decrease in the weave stability and a stabilization of the capsize mode. This effect is mainly caused by the twisting torque. Different tyres and tyre inflation pressures have little effect on the bicycle’s stability, in the case of riding straight at a constant forward speed. On the other hand, the tyre load does have a large effect on bicycle stability. The sensitivity study of rider properties shows that body stiffness and damping have a small effect on the weave and capsize mode, whereas arm stiffness destabilizes the capsize mode and arm damping destabilizes the weave mode