Integration of System-Dynamics, Aspect-Programming, and Object-Orientation in System Information Modeling

Contemporary information modeling of enterprise systems only focuses on the technical aspect of the systems, though it is known that they are social-technical (socio-tech) systems in essence. In fact, there are many lessons that can be learned from failures in the management of enterprise systems, which range from a small one (e.g., failure to install a printer driver) to a large one (e.g., nuclear power plant post-accident management). This paper, therefore, proposes that the enterprise system should be viewed as a socio-tech system. The paper presents a novel integrated approach to information modeling of socio-tech enterprise systems. In particular, the approach integrates object-orientation, systems-dynamics (as a means to represent high-level dynamics), and aspect-programming. The paper discusses an example to illustrate how the proposed approach works. © 2012 IEEE.published_or_final_versio

Optical Guidance System /OGS/ for rendezvous and docking Final report

Optical guidance system for Apollo rendezvous and dockin

Cerebral hypometabolism and grey matter density in MAPT intron 10 +3 mutation carriers

Multiple systems tauopathy with presenile dementia (MSTD), a form of frontotemporal dementia with parkinsonism-17 with tau inclusions (FTDP-17T), is a neurodegenerative disorder caused by an (a) to (g) transition at position +3 of intron 10 of the microtubule associated protein tau (MAPT) gene. The mutation causes overexpression of 4 repeat (4R) tau isoforms with increased 4R/3R ratio leading to neurodegeneration. Clinically, these patients primarily present with behavioral variant FTD (bvFTD) and show disinhibition, disordered social comportment, and impaired executive function, memory, and speech. While altered glucose metabolism has been reported in subjects with sporadic bvFTD, it has yet to be investigated in an FTDP-17 sample of this size. In this study, eleven mutation carriers (5 males; mean age = 48.0 ± 6.9 years) and eight non-carriers (2 males; mean age = 43.7 ± 12.0 years) from a MSTD family were imaged using [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET). Eight of the MAPT intron 10 +3 mutation carriers met diagnostic criteria for bvFTD at the time of the PET scan, while three MAPT intron 10 +3 carriers were not cognitively impaired at the time of scan. Non-carriers had no clinically-relevant cognitive impairment at the time of the PET scan. Additionally, ten mutation carriers (5 males; mean age = 48.04 ± 2.1 years) and seven non-carriers (2 males; mean age 46.1 ± 4.1 years) underwent magnetic resonance imaging (MRI) which is an expanded sample size from a previous study. Seven MAPT mutation carriers met diagnostic criteria for bvFTD at the time of the MRI scan. Images were assessed on a voxel-wise basis for the effect of mutation carrier status. SPM8 was used for preprocessing and statistical analyses. Compared to non-carriers, MAPT mutation carriers showed lower [(18)F]FDG uptake bilaterally in the medial temporal lobe, and the parietal and frontal cortices. Anatomical changes were predominantly seen bilaterally in the medial temporal lobe areas which substantially overlapped with the hypometabolism findings. These anatomical and metabolic changes overlap previously described patterns of neurodegeneration in MSTD patients and are consistent with the characteristics of their cognitive dysfunction. These results suggest that neuroimaging can describe the neuropathology associated with this MAPT mutation

Propulsion System Testing for a Long-Endurance Solar-Powered Unmanned Aircraft

The increase in popularity of unmanned aerial vehicles (UAVs) has been driven by their use in civilian, education, government, and military applications. However, limited on-board energy storage significantly limits flight time and ultimately usability. The propulsion system plays a critical part in the overall energy consumption of the UAV; therefore, it is necessary to determine the most optimal combination of possible propulsion system components for a given mission profile, i.e. propellers, motors, and electronic speed controllers (ESC). Hundreds of options are available for the different components with little performance specifications available for most of them. In order to determine the performance specifications, a propulsion system testing apparatus has been developed and validated. This testing apparatus was designed to measure the performance and efficiency parameters of electric propulsion system components (propellers, motors, and ESC) while maintaining similar air flow characteristics in either a wind tunnel or on a moving automotive platform. Validation tests of four propellers are presented. All four propellers were tested under static conditions, and two were tested under advancing flow conditions where the testing apparatus was used on an automotive platform. The results show that this propulsion testing system provides for holistic testing of all possible compatible electric propulsion system components in a flight-like environment. Data from this system will be used in a mission-based propulsion system optimizer, currently in development, to select the best combination of components for a long-endurance solar-powered unmanned aircraft

[(11)C]PiB PET in Gerstmann-Sträussler-Scheinker disease

Gerstmann-Sträussler-Scheinker Disease (GSS) is a familial neurodegenerative disorder characterized clinically by ataxia, parkinsonism, and dementia, and neuropathologically by deposition of diffuse and amyloid plaques composed of prion protein (PrP). The purpose of this study was to evaluate if [(11)C]Pittsburgh Compound B (PiB) positron emission tomography (PET) is capable of detecting PrP-amyloid in PRNP gene carriers. Six individuals at risk for GSS and eight controls underwent [(11)C]PiB PET scans using standard methods. Approximately one year after the initial scan, each of the three asymptomatic carriers (two with PRNP P102L mutation, one with PRNP F198S mutation) underwent a second [(11)C]PiB PET scan. Three P102L carriers, one F198S carrier, and one non-carrier of the F198S mutation were cognitively normal, while one F198S carrier was cognitively impaired during the course of this study. No [(11)C]PiB uptake was observed in any subject at baseline or at follow-up. Neuropathologic study of the symptomatic individual revealed PrP-immunopositive plaques and tau-immunopositive neurofibrillary tangles in cerebral cortex, subcortical nuclei, and brainstem. PrP deposits were also numerous in the cerebellar cortex. This is the first study to investigate the ability of [(11)C]PiB PET to bind to PrP-amyloid in GSS F198S subjects. This finding suggests that [(11)C]PiB PET is not suitable for in vivo assessment of PrP-amyloid plaques in patients with GSS

The Fine Guidance Sensor, An Electronic Scanning Star Tracker

The advent of space exploration has placed hitherto unheard of requirements on accuracy and precision sensing devices for guidance and attitude control. The necessity for high reliability, due to non-repairability, required new approaches to this design problem. Rather than try to improve upon existing systems, components, and approaches, a totally new concept evolved which eliminates the mechanical rotors and reticles of yesterday. Instead, a totally new breed of electronic scanning star sensor resulted. This paper describes one such device, a Boresighted Star and Planet Tracker developed for precise attitude sensing and control of an experimental sounding rocket. Discussed are the major elements of the basic sensing system, optics, detector, and electronics. The heart of the new sensor is the electronic scanning multiplier phototube, a small, rugged, highly accurate and highly reliable device. Electronic circuit design to enhance accuracy and precision is outlined

Performance Testing of APC Electric Fixed-Blade UAV Propellers

The increase in popularity of unmanned aerial vehicles (UAVs) has been driven by their use in civilian, education, government, and military applications. However, limited on-board energy storage significantly limits flight time and ultimately usability. The propulsion system plays a critical part in the overall energy consumption of the UAV; therefore, it is necessary to determine the most optimal combination of possible propulsion system components for a given mission profile, i.e., propellers, motors, and electronic speed controllers (ESC). Hundreds of options are available for the different components with little performance specifications available for most of them. APC Thin Electric propellers were identified as the most commonly used type of commercial-off-the-shelf propeller. However, little performance data exist in the open literature for the APC Thin Electric propellers with larger diameters. This paper describes the performance testing of 17 APC Thin Electric 2-bladed, fixed propellers with diameters of 12 to 21 in with various pitch values. The propellers were tested at rotation rates of 1,000 to 7,000 RPM and advancing flows of 8 to 80 ft/s, depending on the propeller and testing equipment limitations. Results are presented for the 17 propellers tested under static and advancing flow conditions with several key observations being discussed. The data produced will be available for download on the UIUC Propeller Data Site and on the Unmanned Aerial Vehicle Database

Static Performance Results of Propellers Used on Nano, Micro, and Mini Quadrotors

An increase in the number of small quadrotors has created the interest in having performance data on the propellers used by these aircraft. With an aircraft size less than 5 in and propellers diameters less than 3 in, these quadrotors are typically referred to mini, micro, or nano by hobbyists and manufacturers. The size of the propellers used on these aircraft operate at low Reynolds numbers that are typically less than 50,000 for diameters up to 3 in and less than 20,000 for diameters up to 2 in. Static performance testing of the propellers used on 11 small quadrotors was completed. For propellers with diameters less than 1.4 in, the torque produced was too small to accurately measure

Structure and Ionic Conductivity in the Mixed-Network Former Chalcogenide Glass System [Na2S]2/3[(B2S3)x(P2S5)1–x]1/3

Glasses in the system [Na2S]2/3[(B2S3)x(P2S5)1–x]1/3 (0.0 ≤ x ≤ 1.0) were prepared by the melt quenching technique, and their properties were characterized by thermal analysis and impedance spectroscopy. Their atomic-level structures were comprehensively characterized by Raman spectroscopy and 11B, 31P, and 23Na high resolution solid state magic-angle spinning (MAS) NMR techniques. 31P MAS NMR peak assignments were made by the presence or absence of homonuclear indirect 31P–31P spin–spin interactions as detected using homonuclear J-resolved and refocused INADEQUATE techniques. The extent of B–S–P connectivity in the glassy network was quantified by 31P{11B} and 11B{31P} rotational echo double resonance spectroscopy. The results clearly illustrate that the network modifier alkali sulfide, Na2S, is not proportionally shared between the two network former components, B and P. Rather, the thiophosphate (P) component tends to attract a larger concentration of network modifier species than predicted by the bulk composition, and this results in the conversion of P2S74–, pyrothiophosphate, Na/P = 2:1, units into PS43–, orthothiophosphate, Na/P = 3:1, groups. Charge balance is maintained by increasing the net degree of polymerization of the thioborate (B) units through the formation of covalent bridging sulfur (BS) units, B–S–B. Detailed inspection of the 11B MAS NMR spectra reveals that multiple thioborate units are formed, ranging from neutral BS3/2 groups all the way to the fully depolymerized orthothioborate (BS33–) species. On the basis of these results, a comprehensive and quantitative structural model is developed for these glasses, on the basis of which the compositional trends in the glass transition temperatures (Tg) and ionic conductivities can be rationalized. Up to x = 0.4, the dominant process can be described in a simplified way by the net reaction equation P1 + B1 P0 + B4, where the superscripts denote the number of BS atoms for the respective network former species. Above x = 0.4, all of the thiophosphate units are of the P0 type and both pyro- (B1) and orthothioborate (B0) species make increasing contributions to the network structure with increasing x. In sharp contrast to the situation in sodium borophosphate glasses, four-coordinated thioborate species are generally less abundant and heteroatomic B–S–P linkages appear to not exist. On the basis of this structural information, compositional trends in the ionic conductivities are discussed in relation to the nature of the charge-compensating anionic species and the spatial distribution of the charge carriers

MediChainTM: A Secure Decentralized Medical Data Asset Management System

The set of distributed ledger architectures known as blockchain is best known for cryptocurrency applications such as Bitcoin and Ethereum. These permissionless block chains are showing the potential to be disruptive to the financial services industry. Their broader adoption is likely to be limited by the maximum block size, the cost of the Proof of Work consensus mechanism, and the increasing size of any given chain overwhelming most of the participating nodes. These factors have led to many cryptocurrency blockchains to become centralized in the nodes with enough computing power and storage to be a dominant miner and validator. Permissioned chains operate in trusted environments and can, therefore, avoid the computationally expensive consensus mechanisms. Permissioned chains are still susceptible to asset storage demands and non-standard user interfaces that will impede their adoption. This paper describes an approach to addressing these limitations: permissioned blockchain that uses off-chain storage of the data assets and this is accessed through a standard browser and mobile app. The implementation in the Hyperledger framework is described as is an example use of patient-centered health data management.Comment: 2018 IEEE Confs on Internet of Things, Green Computing and Communications, Cyber, Physical and Social Computing, Smart Data, Blockchain, Computer and Information Technology, Congress on Cybermatic