Mathematical Modeling Of Horizontal Displacement Of Above-ground Gas Pipelines

The modern geodetic equipment allows observations as soon as possible, providing high accuracy and productivity. Achieving high accuracy of measurement is impossible without taking into account external factors that create influence on an observation object. Therefore, in order to evaluate an influence of thermal displacement on the results of geodetic monitoring a mathematical model of horizontal displacement of above-ground pipelines was theoretically grounded and built. In this paper we used data of experimental studies on the existing pipelines "Soyuz" and "Urengoy - Pomary - Uzhgorod". Above-ground pipeline was considered as a dynamic system "building - environment". Based on the characteristics of dynamic systems the correlation between the factors of thermal influence and horizontal displacement of the pipeline axis was defined.Establishing patterns between input factors and output response of the object can be useful not only for geodetic control, but also for their consideration in the design of new objects. It was investigated that the greatest influence on the accuracy of geodetic observations can create dispersion of high-frequency oscillations caused by daily thermal displacement. The magnitude of displacement exceeds actual measurement error.The article presents the results of calculation of high-frequency oscillations of above-ground gas pipeline.The result made it possible to substantiate the accuracy and methodology of geodetic observations of the horizontal displacement of pipeline axes taking into account an influence of cyclical thermal displacement.Research results were recommended for use in practice for enterprises that serve the main gas pipelines and successfully tested by specialists of PJSC "Ukrtransgaz" (Kharkiv, Ukraine) during the technical state control of aerial pipeline crossing in Ukraine and also can be used to form the relevant regulations

Use of Meldonium in the Treatment of Patients with Coronary Artery Disease and Concomitant Arterial Hypertension

Coronary artery disease (CAD) remains one of the leading causes of mortality and disability in Ukraine. Arterial hypertension (AH) is one of the most common diseases and a leading risk factor for coronary artery disease.The aim of the work is to evaluate the antianginal activity of meldonium in the complex therapy in patients with CAD with stable angina and concomitant AH.Materials and methods. The study included 82 patients with CAD, stable angina pectoris II–III functional class, including 52 patients with concomitant AH stage II. The patients were divided into 2 groups. Patients in group 1 were prescribed meldonium at a dose of 750 mg/d for 2 months in addition to basic therapy for the underlying disease. Patients in group 2 continued basic antianginal, disaggregant, hypolipidemic therapy.Results. The use of meldonium led to a decrease in the frequency of angina attacks and the need for nitroglycerin. From the 1st month of therapy and up to 2 months treatment decreased it consumption by 63 and 82.3 % respectively. Adding meldonium to basic therapy led to a likely reduction in shortness of breath, episodes of palpitations, tinnitus, and headache. In all patients, after the treatment, an increase in exercise tolerance was observed, which was more pronounced in the group where patients were receiving meldonium. In the group of patients receiving meldonium, normalisation of blood pressure was faster and more pronounced.Conclusions. Meldonium has antianginal activity, which is manifested by an increase in the physical tolerance of patients, a decrease in the frequency of angina attacks, the need for sublingual nitroglycerin intake and improvement in the well-being of patients. Additional use of meldonium promotes faster and better normalization of blood pressure. The use of meldonium in the complex therapy of patients with stable angina and concomitant AH allows to increase the effectiveness of traditional antianginal therapy and to improve the quality of life of such patients

Rashba Torque Driven Domain Wall Motion in Magnetic Helices

Manipulation of the domain wall propagation in magnetic wires is a key practical task for a number of devices including racetrack memory and magnetic logic. Recently, curvilinear effects emerged as an efficient mean to impact substantially the statics and dynamics of magnetic textures. Here, we demonstrate that the curvilinear form of the exchange interaction of a magnetic helix results in an effective anisotropy term and Dzyaloshinskii--Moriya interaction with a complete set of Lifshitz invariants for a one-dimensional system. In contrast to their planar counterparts, the geometrically induced modifications of the static magnetic texture of the domain walls in magnetic helices offer unconventional means to control the wall dynamics relying on spin-orbit Rashba torque. The chiral symmetry breaking due to the Dzyaloshinskii-Moriya interaction leads to the opposite directions of the domain wall motion in left- or right-handed helices. Furthermore, for the magnetic helices, the emergent effective anisotropy term and Dzyaloshinskii-Moriya interaction can be attributed to the clear geometrical parameters like curvature and torsion offering intuitive understanding of the complex curvilinear effects in magnetism

Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials

Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive–compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine (< 400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale–Brown Obsessive Compulsive Scale scores (P = 0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission

Biomimetic microelectronics for regenerative neuronal cuff implants

Smart biomimetics, a unique class of devices combining the mechanical adaptivity of soft actuators with the imperceptibility of microelectronics, is introduced. Due to their inherent ability to self‐assemble, biomimetic microelectronics can firmly yet gently attach to an inorganic or biological tissue enabling enclosure of, for example, nervous fibers, or guide the growth of neuronal cells during regeneration

Lower gastrointestinal bleeding-Computed Tomographic Angiography, Colonoscopy or both?

Lower endoscopy (LE) is the standard diagnostic modality for lower gastrointestinal bleeding (LGIB). Conversely, computed tomographic angiography (CTA) offers an immediate non-invasive diagnosis visualizing the entire gastrointestinal tract. The aim of this study was to compare these 2 modalities with regards to diagnostic value and bleeding control. Tertiary center retrospective analysis of consecutive patients admitted for LGIB between 2006 and 2012. Comparison of patients with LE &lt;i&gt;vs.&lt;/i&gt; CTA as first exam, respectively, with emphasis on diagnostic accuracy and bleeding control. Final analysis included 183 patients; 122 (66.7%) had LE first, while 32 (17.5%) had CTA; 29 (15.8%) had neither of both exams. Median time to CTA was shorter compared to LE (3 (IQR = 8.2) &lt;i&gt;vs.&lt;/i&gt; 22 (IQR = 36.9) hours, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). Active bleeding was identified in 31% with CTA &lt;i&gt;vs.&lt;/i&gt; 15% with LE ( &lt;i&gt;P&lt;/i&gt; = 0.031); a non-actively bleeding source was found by CTA and LE in 22 &lt;i&gt;vs.&lt;/i&gt; 31%, respectively ( &lt;i&gt;P&lt;/i&gt; = 0.305). Bleeding control required endoscopy in 19%, surgery in 14% and embolization in 1.6%, while 66% were treated conservatively. Post-interventional bleeding was mostly controlled by endoscopic therapy (57%). 80% of patients with active bleeding on CTA required surgery. Post-interventional LGIB was effectively addressed by LE. For other causes of LGIB, CTA was efficient, and more available than colonoscopy. Treatment was conservative for most patients. In case of active bleeding, CTA could localize the bleeding source and predict the need for surgery