Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions.

The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty-six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. Regardless of the presence of dopaminergic denervation, cerebrovascular lesions in hemispheric white matter, basal ganglia, and cerebellum have an important effect in determining early onset and severity of cognitive impairment in patients with parkinsonism

A textbook example of ram-pressure stripping in the Hydra A/A780 cluster

In the current epoch, one of the main mechanisms driving the growth of galaxy clusters is the continuous accretion of group-scale halos. In this process, the ram pressure applied by the hot intracluster medium on the gas content of the infalling group is responsible for stripping the gas from its dark-matter halo, which gradually leads to the virialization of the infalling gas in the potential well of the main cluster. Using deep wide-field observations of the poor cluster Hydra A/A780 with XMM-Newton and Suzaku, we report the discovery of an infalling galaxy group 1.1 Mpc south of the cluster core. The presence of a substructure is confirmed by a dynamical study of the galaxies in this region. A wake of stripped gas is trailing behind the group over a projected scale of 760 kpc. The temperature of the gas along the wake is constant at kT ~ 1.3 keV, which is about a factor of two less than the temperature of the surrounding plasma. We observe a cold front pointing westwards compared to the peak of the group, which indicates that the group is currently not moving in the direction of the main cluster, but is moving along an almost circular orbit. The overall morphology of the group bears remarkable similarities with high-resolution numerical simulations of such structures, which greatly strengthens our understanding of the ram-pressure stripping process

Prevalence of Defaecatory Disorders in Morbidly Obese Patients Before and After Bariatric Surgery

BACKGROUND: The prevalence of obesity is increasing worldwide and has lately reached epidemic proportions in western countries. Several epidemiological studies have consistently shown that both overweight and obesity are important risk factors for the development of various functional defaecatory disorders (DDs), including faecal incontinence and constipation. However, data on their prevalence as well as effectiveness of bariatric surgery on their correction are scant. The primary objective of this study was to estimate the effect of morbid obesity on DDs in a cohort of patients listed for bariatric surgery. We also evaluated preliminary results of the effects of sleeve gastrectomy on these disorders. PATIENTS AND METHODS: A questionnaire-based study was proposed to morbidly obese patients having bariatric surgery. Data included demographics, past medical, surgical and obstetrics histories, as well as obesity related co-morbidities. Wexner Constipation Score (WCS) and the Faecal Incontinence Severity Index (FISI) questionnaires were used to evaluate constipation and incontinence. For the purpose of this study, we considered clinically relevant a WCS ≥5 and a FISI score ≥10. The same questionnaires were completed at 3 and 6 months follow-up after surgery. RESULTS: A total of 139 patients accepted the study and 68 underwent sleeve gastrectomy and fully satisfied our inclusion criteria with a minimum follow-up of 6 months. Overall, mean body mass index (BMI) at listing was 47 ± 7 kg/m(2) (range 35-67 kg/m(2)). Mean WCS was 4.1 ± 4 (range 0-17), while mean FISI score (expressed as mean±standard deviation) was 9.5 ± 9 (range 0-38). Overall, 58.9% of the patients reported DDs according to the above-mentioned scores. Twenty-eight patients (20%) had WCS ≥5. Thirty-five patients (25%) had a FISI ≥10 while 19 patients (13.7%) reported combined abnormal scores. Overall, DDs were more evident with the increase of obesity grade: Mean BMI decreased significantly from 47 ± 7 to 36 ± 6 and to 29 ± 4 kg/m(2) respectively at 3 and 6 months after surgery (p < 0.0001). According to the BMI decrease, the mean WCS decreased from 3.7 ± 3 to 3.1 ± 4 and to 1.6 ± 3 respectively at 3 and 6 months (p = 0.02). Similarly, the FISI score decreased from 10 ± 8 to 3 ± 4 and to 1 ± 2 respectively at 3 and 6 months (p = 0.0001). CONCLUSIONS: Defaecatory disorders are common in morbidly obese patients. The risk of DDs increases with BMI. Bariatric surgery reduces DDs, mainly faecal incontinence, and these findings correlated with BMI reduction

NPS pollution analysis in groundwater and streams of rural watersheds in western and southeastern Pampas, Argentina

Non-point source water pollution is a key question in rural watersheds and it needs to be studied in order to prevent damages to ground and surface water quality. The main goal of this study is to analyze nutrient and chemical loads in groundwater and streams in Pampa region, Argentina. For studying groundwater loads, a set of 19 observation wells were installed in 2011, in western Buenos Aires. The wells were located at three landscape positions (upper, middle and lower hill) in seven agricultural fields and groundwater samples were monthly collected. As for surface water, two watersheds located in southeastern Buenos Aires, were chosen: Napaleofu creek Watershed (34.000 hectares) and Quequen Grande River watershed (938.000 hectares). Daily water samples were taken from the main stream from October 2011 to May 2013, at both watersheds. Water Samples collected from wells and streams, were analyzed to determine N, and chemical loads. A group of 11 herbicides and one insecticide frequently used by farmers in the watershed were chosen for the study. Nitrogen and chemical concentrations were analyzed considering rainfall events and also compared to critical limits. Preliminary results are presented from a subset of samples since remaining samples are currently being processed in laboratory. As for NO3-N concentration, most of wells presented variable concentration depending on monthly precipitation and landscape position. Considering 10 mg/L NO3-N as a standard limit, 52% of the observations exceed this value mostly related to unusual precipitations events at winter 2012. Nitrate-Nconcentration in streamflow at Quequen Grande River and Napaleofu creek were on average 5 ppm. NPS Pollution modeling is a second goal of this on-going research. SWAT validation results are also presented for one of the watersheds under study

Mean Area of Self-Avoiding Loops

The mean area of two-dimensional unpressurised vesicles, or self-avoiding loops of fixed length $N$, behaves for large $N$ as $A_0 N^{3/2}$, while their mean square radius of gyration behaves as $R^2_0 N^{3/2}$. The amplitude ratio $A_0/R_0^2$ is computed exactly and found to equal $4\pi/5$. The physics of the pressurised case, both in the inflated and collapsed phases, may be usefully related to that of a complex O(n) field theory coupled to a U(1) gauge field, in the limit $n \to 0$.Comment: 12 pages, plain TeX, (one TeX macro omission corrected

Iron in x-cop: Tracing enrichment in cluster outskirts with high accuracy abundance profiles

We present the first metal abundance profiles for a representative sample of massive clusters. Our measurements extend to R500 and are corrected for a systematic error plaguing previous outskirt estimates. Our profiles flatten out at large radii, admittedly not a new result, however the radial range and representative nature of our sample extends its import well beyond previous findings. We find no evidence of segregation between cool-core and non-cool-core systems beyond 3c0.3\ue2 R500, implying that, as was found for thermodynamic properties, the physical state of the core does not affect global cluster properties. Our mean abundance within R500 shows a very modest scatter, < 15%, suggesting the enrichment process must be quite similar in all these massive systems. This is a new finding and has significant implications for feedback processes. Together with results from the thermodynamic properties presented in a previous X-COP paper, it affords a coherent picture in which feedback effects do not vary significantly from one system to another. By combining intra-cluster medium with stellar measurements we have found the amount of Fe diffused in the intra-cluster medium to be about ten times higher than that locked in stars. Although our estimates suggest, with some strength, that the measured iron mass in clusters is well in excess of the predicted one, systematic errors prevent us from making a definitive statement. Further advancements will only be possible when systematic uncertainties, principally those associated with stellar masses, both within and beyond R500, can be reduced

Non-thermal pressure support in X-COP galaxy clusters

Galaxy clusters are the endpoints of structure formation and are continuously growing through the merging and accretion of smaller structures. Numerical simulations predict that a fraction of their energy content is not yet thermalized, mainly in the form of kinetic motions (turbulence, bulk motions). Measuring the level of non-thermal pressure support is necessary to understand the processes leading to the virialization of the gas within the potential well of the main halo and to calibrate the biases in hydrostatic mass estimates. We present high-quality measurements of hydrostatic masses and intracluster gas fraction out to the virial radius for a sample of 13 nearby clusters with available XMM-Newton and Planck data. We compare our hydrostatic gas fractions with the expected universal gas fraction to constrain the level of non-thermal pressure support. We find that hydrostatic masses require little correction and infer a median non-thermal pressure fraction of ∼6% and ∼10% at R500 and R200, respectively. Our values are lower than the expectations of hydrodynamical simulations, possibly implying a faster thermalization of the gas. If instead we use the mass calibration adopted by the Planck team, we find that the gas fraction of massive local systems implies a mass bias 1 − b = 0.85 ± 0.05 for Sunyaev– Zeldovich-derived masses, with some evidence for a mass-dependent bias. Conversely, the high bias required to match Planck cosmic microwave background and cluster count cosmology is excluded by the data at high significance, unless the most massive halos are missing a substantial fraction of their baryons

Efficacy of Multisensory Technology in Post-Stroke Cognitive Rehabilitation: A Systematic Review

Post-stroke, in addition to sensorimotor signs and symptoms, could lead to cognitive deficits. Theories of embodiment stress the role of sensorimotor system and multisensory integration in sustaining high-order cognitive domains. Despite conventional post-stroke cognitive rehabilitation being effective, innovative technologies could overcome some limitations of standard interventions and exploit bodily information during cognitive rehabilitation. This systematic review aims to investigate whether ‘multisensory technologies’ compared to usual care treatment can be a viable alternative for cognitive rehabilitation. By applying PRISMA guidelines, we extracted data and assessed the bias of 10 studies that met the required criteria. We found that multisensory technologies were at least comparable to standard treatment but particularly effective for attention, spatial cognition, global cognition, and memory. Multisensory technologies consisted principally of virtual reality alone or combined with a motion tracking system. Multisensory technologies without motion tracking were more effective than standard procedures, whereas those with motion tracking showed balanced results for the two treatments. Limitations of the included studies regarded the population (e.g., no study on acute stroke), assessment (e.g., lack of multimodal/multisensory pre-post evaluation), and methodology (e.g., sample size, blinding bias). Recent advancements in technological development and metaverse open new opportunities to design embodied rehabilitative programs

Particle re-acceleration and diffuse radio sources in the galaxy cluster Abell 1550

We study diffuse radio emission in the galaxy cluster A1550, with the aim of constraining particle re-acceleration in the intra-cluster medium. We exploit observations at four different frequencies: 54, 144, 400 and 1400 MHz. To complement our analysis, we make use of archival Chandra X-ray data. At all frequencies we detect an ultra-steep spectrum radio halo ($S_\nu \propto \nu^{-1.6}$) with an extent of 1.2 Mpc at 54 MHz. Its morphology follows the distribution of the thermal intra-cluster medium inferred from the Chandra observation. West of the centrally located head-tail radio galaxy, we detect a radio relic with projected extent of 500 kpc. From the relic, a 600 kpc long bridge departs and connect it to the halo. Between the relic and the radio galaxy, we observe what is most likely a radio phoenix, given its curved spectrum. The phoenix is connected to the tail of the radio galaxy through two arms, which show a nearly constant spectral index for 300 kpc. The halo could be produced by turbulence induced by a major merger, with its axis lying in the NE-SW direction. This is supported by the position of the relic, whose origin could be attributed to a shock propagating along the merger axis. It is possible that the same shock has also produced the phoenix through adiabatic compression, while the bridge could be generated by electrons which were pre-accelerated by the shock, and then re-accelerated by turbulence. Finally, we detect hints of gentle re-energisation in the two arms which depart from the tail of the radio galaxy.Comment: 16 pages, 10 figure