Curvatures and potential of M-theory in D=4 with fluxes and twist

We give the curvatures of the free differential algebra (FDA) of M--theory compactified to D=4 on a twisted seven--torus with the 4--form flux switched on. Two formulations are given, depending on whether the 1--form field strengths of the scalar fields (originating from the 3--form gauge field $\hat{A}^{(3)}$) are included or not in the FDA. We also give the bosonic equations of motion and discuss at length the scalar potential which emerges in this type of compactifications. For flat groups we show the equivalence of this potential with a dual formulation of the theory which has the full \rE_{7(7)} symmetry.Comment: 14 pages, LaTeX source, typos correcte

Type-IIA flux compactifications and N=4 gauged supergravities

We establish the precise correspondence between Type-IIA flux compactifications preserving an exact or spontaneously broken N=4 supersymmetry in four dimensions, and gaugings of their effective N=4 supergravities. We exhibit the explicit map between fluxes and Bianchi identities in the higher-dimensional theory and generalized structure constants and Jacobi identities in the reduced theory, also detailing the origin of gauge groups embedded at angles in the duality group. We present AdS4 solutions of the massive Type-IIA theory with spontaneous breaking to N=1, at small string coupling and large volume, and discuss their dual CFT3.Comment: 43 pages, 1 figure. v2: refs added, v3: minor additions. Final version to appear on JHE

The linear spectrum of OSp(32|1) Chern-Simons supergravity in eleven dimensions

We study linearized perturbations of eleven-dimensional $OSp(32|1)$ Chern-Simons supergravity. The action contains a term that changes the value of the cosmological constant, as considered by Horava. It is shown that the spectrum contains a 3-form and a 6-form whose field strengths are dual to each other, thus providing a link with the eleven-dimensional supergravity of Cremmer, Julia and Scherk. The linearized equations for the graviton and Rarita-Schwinger field are shown to be the standard ones as well.Comment: Minor additions. To appear in PRL. 4 pages, twocolumn, Revtex

Superconformal field theories from IIB spectroscopy on AdS5×T11AdS_5\times T^{11}

We report on tests of the AdS/CFT correspondence that are made possible by complete knowledge of the Kaluza-Klein mass spectrum of type IIB supergravity on $AdS_5 \times T^{11}$ with T^{11}=SU(2)^2/U(1). After briefly discussing general multiplet shortening conditions in SU(2,2|1) and PSU(2,2|4), we compare various types of short SU(2,2|1) supermultiplets on AdS_5 and different families of boundary operators with protected dimensions. The supergravity analysis predicts the occurrence in the SCFT at leading order in N and g_s N, of extra towers of long multiplets whose dimensions are rational but not protected by supersymmetry.Comment: 11 pages, To appear in the proceedings of the STRINGS '99 conference, Potsdam (Germany), 19-25 July 199

Constrained generalized supersymmetries and superparticles with tensorial central charges. A classification

We classify the admissible types of constraint (hermitian, holomorphic, with reality conditions on the bosonic sectors, etc.) for generalized supersymmetries in the presence of complex spinors. We further point out which constrained generalized supersymmetries admit a dual formulation. For both real and complex spinors generalized supersymmetries are constructed and classified as dimensional reductions of supersymmetries from {\em oxidized} space-times (i.e. the maximal space-times associated to $n$-component Clifford irreps). We apply these results to sistematically construct a class of models describing superparticles in presence of bosonic tensorial central charges, deriving the consistency conditions for the existence of the action, as well as the constrained equations of motion. Examples of these models (which, in their twistorial formulation, describe towers of higher-spin particles) were first introduced by Rudychev and Sezgin (for real spinors) and later by Bandos and Lukierski (for complex spinors).Comment: 32 pages, LaTe

N=1 effective potential from dual type-IIA D6/O6 orientifolds with general fluxes

We consider N=1 compactifications of the type-IIA theory on the T6/(Z2xZ2) orbifold and O6 orientifold, in the presence of D6-branes and general NSNS, RR and Scherk-Schwarz geometrical fluxes. Introducing a suitable dual formulation of the theory, we derive and solve the Bianchi identities, and show how certain combinations of fluxes can relax the constraints on D6-brane configurations coming from the cancellation of RR tadpoles. We then compute, via generalized dimensional reduction, the N=1, D=4 effective potential for the seven main moduli, and comment on the relation with truncated N=4 gaugings. As a byproduct, we obtain a general geometrical expression for the superpotential. We finally identify a family of fluxes, compatible with all Bianchi identities, that perturbatively stabilize all seven moduli in supersymmetric AdS4.Comment: 19 pages, no figures, JHEP3 LaTeX. Published versio

Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer. Efficacy in combination with hormonal therapy

Background: Data on efficacy of bevacizumab (B) beyond first-line taxane -including regimen (BT) as first-line treatment are lacking. Although preclinical results that anti-angiogenic agents combined with hormonal therapy (HT) could be active, no clinical data exist about combination of maintenance Bevacizumab (mBev) with HT.Methods: Thirty-five patients who experienced a response after first-line BT, were given mBev at the dose of 15 mg/kg every 3 weeks. Among 30 pts with hormonal receptor-positive metastatic breast cancer (MBC), 20 (66.6%) received HT with mBev (mHTBev). Objective of the study was the outcome and safety of mBev and in two groups of patients receiving HT or not.Results: Complete response and partial response was achieved/maintained in 4 (11.4%) and 13 (37.1%) patients, respectively (overall response rate: 48.5%). Clinical benefit was obtained on 23 patients (65.7%). Median of mBev PFS and clinical benefit were 6.8 months (95% CI: 0.8-12.7) and 17.1 months (95% CI :12.2-21.9), respectively. Median PFS of patients who received mHTBev was longer than mBev without HT (13 months and 4.1 months, respectively, p = 0.05). The most common severe toxicities were proteinuria (11.4%) and hypertension (8.5%). No additional toxicity was observed with HTBev.Conclusion: Maintenance bevacizumab with or without anti-hormonal therapy in patients with hormone receptor positive breast cancer is tolerable and associated with long-term clinical outcome; these results encourage the strategy of prolonging bevacizumab until progression in combination with anti-hormonal agents

Type II compactifications on manifolds with SU(2) x SU(2) structure

We study compactifications of type II theories on SU(2) x SU(2) structure manifolds to six, five and four spacetime dimensions. We use the framework of generalized geometry to describe the NS-NS sector of such compactifications and derive the structure of their moduli spaces. We show that in contrast to SU(3) x SU(3) structure compactifications, there is no dynamical SU(2) x SU(2) structure interpolating between an SU(2) structure and an identity structure. Furthermore, we formulate type II compactifications on SU(2) x SU(2) structures in the context of exceptional generalized geometry which makes the U-duality group manifest and naturally incorporates the scalar degrees of freedom arising in the Ramond-Ramond sector. Via this formalism we derive the structure of the moduli spaces as it is expected from N=4 supergravity.Comment: 69 pages, v2 published versio

Hermitian versus holomorphic complex and quaternionic generalized supersymmetries of the M-theory. A classification

Relying upon the division-algebra classification of Clifford algebras and spinors, a classification of generalized supersymmetries (or, with a slight abuse of language,"generalized supertranslations") is provided. In each given space-time the maximal, saturated, generalized supersymmetry, compatible with the division-algebra constraint that can be consistently imposed on spinors and on superalgebra generators, is furnished. Constraining the superalgebra generators in both the complex and the quaternionic cases gives rise to the two classes of constrained hermitian and holomorphic generalized supersymmetries. In the complex case these two classes of generalized supersymmetries can be regarded as complementary. The quaternionic holomorphic supersymmetry only exists in certain space-time dimensions and can admit at most a single bosonic scalar central charge. The results here presented pave the way for a better understanding of the various $M$ algebra-type of structures which can be introduced in different space-time signatures and in association with different division algebras, as well as their mutual relations. In a previous work, e.g., the introduction of a complex holomorphic generalized supersymmetry was shown to be necessary in order to perform the analytic continuation of the standard $M$-theory to the 11-dimensional Euclidean space. As an application of the present results, it is shown that the above algebra also admits a 12-dimensional, Euclidean, $F$-algebra presentation.Comment: 25 pages, LaTe

Higher Spin Fields in Siegel Space, Currents and Theta Functions

Dynamics of four-dimensional massless fields of all spins is formulated in the Siegel space of complex $4\times 4$ symmetric matrices. It is shown that the unfolded equations of free massless fields, that have a form of multidimensional Schrodinger equations, naturally distinguish between positive- and negative-frequency solutions of relativistic field equations, i.e. particles and antiparticles. Multidimensional Riemann theta functions are shown to solve massless field equations in the Siegel space. We establish the correspondence between conserved higher-spin currents in four-dimensional Minkowski space and those in the ten-dimensional matrix space. It is shown that global symmetry parameters of the current in the matrix space should be singular to reproduce a nonzero current in Minkowski space. The \D-function integral evolution formulae for 4d massless fields in the Fock-Siegel space are obtained. The generalization of the proposed scheme to higher dimensions and systems of higher ranks is considered.Comment: LaTeX, 38 pages, v.3: clarifications, acknowledgements and references added, typos corrected, v.4: more comments and references added, typos corrected, the version to appear in JHE