Middle Holocene environmental change and archaeology in coastal wetlands: further implications for our understanding of the history of Taxus woodland

A radiocarbon-dated multi-proxy palaeoenvironmental record from Beckton in the Lower Thames Valley, Southern England, has permitted a detailed reconstruction of human activities and environmental change during the middle-Holocene. Peat accumulation occurred over river terrace gravels from ca. 7200 to 6600 until at least 3450–3240 cal. BP, and in the later period a trackway and platform structure provide unequivocal evidence for human exploitation of the floodplain environment during the Bronze Age. The site is unique in offering the first certain evidence of the utilisation of Taxus in the construction of a wooden prehistoric platform. Across north-west Europe during the middle-Holocene, the colonisation of Taxus on peat is well documented; at Beckton, it occurred between ca. 5220–4940 and 4410–4220 cal. BP. This research provides important insights into the former distribution of Taxus, and reasons for its expansion and decline during the Holocene, which has relevance to present-day concerns over the conservation and management of Taxus woodland. Abandonment of the site occurred in response to environmental change to wetter conditions. The study employed multi-proxy analyses, including pollen, plant and wood macrofossils, and uniquely Coleoptera; Coleopteran analysis has significant potential to enhance understandings of environmental change and human–environment interactions in coastal wetland research

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis

Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity. Organometallic half-sandwich iridium (IrIII) complexes [Ir(Cpx)(XY)Cl]+/0 (Cpx = biphenyltetramethylcyclopentadienyl and XY = phenanthroline (1), bipyridine (2), or phenylpyridine (3)) all hydrolyze rapidly, forming monofunctional G adducts on DNA with additional intercalation of the phenyl substituents on the Cpx ring. In comparison, highly potent complex 4 (Cpx = phenyltetramethylcyclopentadienyl and XY = N,N-dimethylphenylazopyridine) does not hydrolyze. All show higher potency toward A2780 human ovarian cancer cells compared to cisplatin, with 1, 3, and 4 also demonstrating higher potency in the National Cancer Institute (NCI) NCI-60 cell-line screen. Use of the NCI COMPARE algorithm (which predicts mechanisms of action (MoAs) for emerging anticancer compounds by correlating NCI-60 patterns of sensitivity) shows that the MoA of these IrIII complexes has no correlation to cisplatin (or oxaliplatin), with 3 and 4 emerging as particularly novel compounds. Those findings by COMPARE were experimentally probed by transmission electron microscopy (TEM) of A2780 cells exposed to 1, showing mitochondrial swelling and activation of apoptosis after 24 h. Significant changes in mitochondrial membrane polarization were detected by flow cytometry, and the potency of the complexes was enhanced ca. 5× by co-administration with a low concentration (5 μM) of the γ-glutamyl cysteine synthetase inhibitor L-buthionine sulfoximine (L-BSO). These studies reveal potential polypharmacology of organometallic IrIII complexes, with MoA and cell selectivity governed by structural changes in the chelating ligands

Racism, anti-racist practice and social work: articulating the teaching and learning experiences of Black social workers

In the mid 1990s a Black practice teacher programme was established in Manchester and Merseyside with the primary aim to increase the number of Black practice teachers in social work organisations, and in turn provide a supportive and encouraging learning environment for Black student social workers whilst on placement. In the north‐west of England research has been undertaken, to establish the quality of the practice teaching and student learning taking place with Black practice teachers and students. This paper is an exploration of the ideas generated within the placement process that particularly focused on the discourse of racism and ant‐racist practice. Black students and practice teachers explain their understanding of racism and anti‐racist practice within social work. From the research, the paper will critique some of the ideas concerning anti‐racism. In particular, it will question whether anti‐racist social work practice needs to be re‐evaluated in the light of a context with new migrants, asylum seekers and refugees. It will concluded, by arguing that whilst the terms anti‐racism, Black and Minority Ethnic have resonance as a form of political strategic essentialism, it is important to develop more positive representations in the future

EFFECTS OF ACCESS TO PASTURE AND INTEGRATION WITH RABBITS ON PERFORMANCE AND CARCASS CHARACTERISTICS OF BROILER CHICKEN

The study was conducted during rainy season (June-August) to determine the performance and carcass characteristics of broiler chicken raised on partial free range and integration with rabbits using 180 unsexed Anak broiler chicks

Multivariable control of a nonlinear process : output prioritisation by error redistribution

Bibliography: leaves 149-154

Dynamic behavior of a subcooled BWR core during a rod-drop accident

The techniques and models used in the study of rapid reactivity insertion in a BWR have ranged from approximate conservative methods with simple feedback models to detailed representations of coupled neutronic thermal-hydraulic mechanisms. In a recent paper Cheng and Diamond presented a detailed evaluation of the control rod drop accident (CRDA). Their calculations suggested that the effect of inlet subcooling and rod drop speed may play an important role in determining the severity of the rod drop accident. The purpose of the work summarized in this paper has been to determine in detail the dynamic behavior of a BWR core as the inlet moderator temperature and the speed of the dropped rod are varied

Towards neuro-inspired symbolic models of cognition: linking neural dynamics to behaviors through asynchronous communications

A computational architecture modeling the relation between perception and action is proposed. Basic brain processes representing synaptic plasticity are first abstracted through asynchronous communication protocols and implemented as virtual microcircuits. These are used in turn to build mesoscale circuits embodying parallel cognitive processes. Encoding these circuits into symbolic expressions gives finally rise to neuro-inspired programs that are compiled into pseudo-code to be interpreted by a virtual machine. Quantitative evaluation measures are given by the modification of synapse weights over time. This approach is illustrated by models of simple forms of behaviors exhibiting cognition up to the third level of animal awareness. As a potential benefit, symbolic models of emergent psychological mechanisms could lead to the discovery of the learning processes involved in the development of cognition. The executable specifications of an experimental platform allowing for the reproduction of simulated experiments are given in “Appendix”

‘This restless enemy of all fertility’: exploring paradigms of coastal dune management in Western Europe over the last 700 years

Drifting sand has inundated settlements and damaged agricultural land along the coasts of Western Europe for the last 700 years. The need to control sand migration has been an important driver of the management of coastal sand dunes and here we analyse original archival materials to provide new insights into historically changing coastal dune management practices. Records of coastal sand movement in Denmark, The Netherlands, Britain, Ireland and France were reviewed and three distinct management approaches were identified. The ways in which these approaches have played out in space and time were examined with particular reference to records from landed estates in Britain and Ireland. We demonstrate how historical evidence can be used to inform contemporary debates on dune management strategy and practice. We propose a new place-based approach to the future management of coastal dunes that can incorporate both expert and locally produced ‘knowledges’ and that is underpinned by an understanding of how both natural forces and human interventions have shaped these dune landscapes over time

Ympäristönmuutoksen vaikutukset hedelmien, pähkinöiden ja siementen satoihin ja ravitsemuskoostumukseen: systemaattinen kirjallisuustarkastelu

Background: Environmental changes are predicted to threaten human health, agricultural production and food security. Whilst their impact has been evaluated for major cereals, legumes and vegetables, no systematic evidence synthesis has been performed to date evaluating impact of environmental change on fruits, nuts and seeds (FN&S)-valuable sources of nutrients and pivotal in reducing risks of non-communicable disease. Methods: We systematically searched seven databases, identifying available published literature (1970-2018) evaluating impacts of water availability and salinity, temperature, carbon dioxide (CO2) and ozone (O-3) on yields and nutritional quality of FN&S. Dose-response relationships were assessed and, where possible, mean yield changes relative to baseline conditions were calculated. Results: 81 papers on fruits and 24 papers on nuts and seeds were identified, detailing 582 and 167 experiments respectively. A 50% reduction in water availability and a 3-4dS m(-1) increase in water salinity resulted in significant fruit yield reductions (mean yield changes: -20.7% [95%CI -43.1% to -1.7%]; and -28.2% [95%CI -53.0% to -3.4%] respectively). A 75%-100% increase in CO2 concentrations resulted in positive yield impacts (+37.8%; [95%CI 4.1% to 71.5%]; and 10.1%; [95%CI -30.0% to 50.3%] for fruits and nuts respectively). Evidence on yield impacts of increased O-3 concentrations and elevated temperatures (>25 degrees C) was scarce, but consistently negative. The positive effect of elevated CO2 levels appeared to attenuate with simultaneous exposure to elevated temperatures. Data on impacts of environmental change on nutritional quality of FN&S were sparse, with mixed results. Discussion: In the absence of adaptation strategies, predicted environmental changes will reduce yields of FN&S. With global intake already well-below WHO recommendations, declining FN&S yields may adversely affect population health. Adaptation strategies and careful agricultural and food system planning will be essential to optimise crop productivity in the context of future environmental changes, thereby supporting and safeguarding sustainable and resilient food systems.Peer reviewe

Geology of Rum Cay, Bahamas: A Field Trip Guide

See other Smith authored Field Trip Guides of Gerace Research Centre