Does the inclusion of moderate amounts of red meat in the diet of exercising older women impact on faecal markers of bowel health, including faecal lactoferrin?

Background: High intakes of red meat may be associated with increased risk of colorectal cancer (CRC), however, to determine CRC risk, it is important to assess faecal changes related to protein and carbohydrate metabolism.Objective: To determine the influence of three weekly meals rich in red meat as opposed to a carbohydrate control diet on faecal markers which are involved in the aetiology of CRC.Design: Twenty post-menopausal women (aged 60-75) undertook, 3 times a week for 12 weeks, a 30 minute exercise session followed immediately by a cooked meal that was high in lean red meat, low in carbohydrate (n= 10) or low in lean red meat, high in carbohydrate (n=10). Dietary fibre intake and macronutrients were kept constant. At the beginning and end of the study, three-day faecal samples were collected and by-products of protein fermentation and carbohydrate metabolism, undigested fibre residues, and faecal output and colonic bacterial microbiota changes measured.Outcomes: No significant differences were observed in subjects on either diet when comparing faecal output, faecal pH, other faecal markers, nor faecal lactoferrin. There was a trend observed in changes in the population of colonic microbiota using FISH analysis. Bacteroides spp. and Prevotella spp. appeared to decrease in women consuming a high red meat diet compared with an increase in women consuming a high carbohydrate diet.Conclusions: In this pilot study the trend in colonic microbiota change is interesting and suggests that dietary influence of colonic microbiota, especially changes in Bacteroidetes, may be indicative of risk of gut damage and disease compared to other faecal markers.<br /

Energy density of foods and beverages in the Australian food supply: influence of macronutrients and comparison to dietary intake.

OBJECTIVES: The energy density (ED) of the diet is considered an important determinant of total energy intake and thus energy balance and weight change. We aimed to compare relationships between ED and macronutrient content in individual food and beverage items as well as population diet in a typical Western country. DESIGN: Nutrient data for 3673 food items and 247 beverage items came from the Australian Food and Nutrient database (AusNut). Food and beverage intake data came from the 1995 Australian National Nutrition Survey (a 24-h dietary recall survey in 13 858 people over the age of 2). Relationships between ED and macronutrient and water content were analysed by linear regression with 95% prediction bands. RESULTS: For both individual food items and population food intake, there was a positive relationship between ED and percent energy as fat and negative relationships between ED and percent energy as carbohydrate and percent water by weight. In all cases, there was close agreement between the slopes of the regression lines between food items and dietary intake. There were no clear relationships between ED and macronutrient content for beverage items. Carbohydrate (mostly sucrose) contributed 91, 47, and 25% of total energy for sugar-based, fat-based, and alcohol-based beverages respectively. CONCLUSIONS: The relationship between ED and fat content of foods holds true across both population diets and individual food items available in the food supply in a typical Western country such as Australia. As high-fat diets are associated with a high BMI, population measures with an overall aim of reducing the ED of diets may be effective in mediating the growing problem of overweight and obesity

Reactions of Large Groups of Caribou to a Pipeline Corridor on the Arctic Coastal Plain of Alaska

Two large groups of mosquito-harassed caribou (Rangifer tarandus granti) were followed for 8-12 h as they repeatedly attempted to cross an elevated pipeline in the Kuparuk Development Area near Prudhoe Bay, Alaska. In 1981, 46% of a group of 917 eventually crossed beneath elevated portions of the pipeline in 26 separate attempts, 13% crossed a section of buried pipe in two attempts, 22% trotted parallel to the pipeline for 32 km and did not cross, and 19% separated from the group and were not accounted for. In 1982, 26% of a group of 655 crossed under elevated portions of the pipeline in 36 attempts, 37% crossed at a buried section in one attempt, and 37% left the main group and could not be accounted for. The majority of crossing attempts occured near intersections of lakes with the road/pipeline complex, but crossing success was highest at a section of buried pipe isolated from the road traffic.Key words: caribou, pipeline, petroleum development, insect harassment, Kuparuk Oil FieldMots cl&eacute;s: caribou, pipe-line, d&eacute;veloppement p&eacute;trolif&egrave;re, harc&egrave;lement par les moustiques, champ p&eacute;trolif&egrave;re Kuparu

Kadison-Kastler stable factors

A conjecture of Kadison and Kastler from 1972 asks whether sufficiently close operator algebras in a natural uniform sense must be small unitary perturbations of one another. For n≥3 and a free, ergodic, probability measure-preserving action of SL&lt;sub&gt;n&lt;/sub&gt;(Z) on a standard nonatomic probability space (X,μ), write M=(L&lt;sup&gt;∞&lt;/sup&gt;(X,μ)⋊SL&lt;sub&gt;n&lt;/sub&gt;(Z))⊗¯¯¯R, where R is the hyperfinite II1-factor. We show that whenever M is represented as a von Neumann algebra on some Hilbert space H and N⊆B(H) is sufficiently close to M, then there is a unitary u on H close to the identity operator with uMu∗=N. This provides the first nonamenable class of von Neumann algebras satisfying Kadison and Kastler’s conjecture. We also obtain stability results for crossed products L&lt;sup&gt;∞&lt;/sup&gt;(X,μ)⋊Γ whenever the comparison map from the bounded to usual group cohomology vanishes in degree 2 for the module L&lt;sup&gt;2&lt;/sup&gt;(X,μ). In this case, any von Neumann algebra sufficiently close to such a crossed product is necessarily isomorphic to it. In particular, this result applies when Γ is a free group

A remark on the similarity and perturbation problems

In this note we show that Kadison's similarity problem for C*-algebras is equivalent to a problem in perturbation theory: must close C*-algebras have close commutants?Comment: 6 Pages, minor typos fixed. C. R. Acad. Sci. Canada, to appea

Compact Modeling for a Double Gate MOSFET

MOSFETs (metal-oxide-silicon field-effect transistors) are an integral part of modern electronics. Improved designs are currently under investigation, and one that is promising is the double gate MOSFET. Understanding device characteristics is critical for the design of MOSFETs as part of design tools for integrated circuits such as SPICE. Current methods involve the numerical solution of PDEs governing electron transport. Numerical solutions are accurate, but do not provide an appropriate way to optimize the design of the device, nor are they suitable for use in chip simulation software such as SPICE. As chips contain more and more transistors, this problem will get more and more acute. There is hence a need for analytic solutions of the equations governing the performance of MOSFETs, even if these are approximate. Almost all solutions in the literature treat the long-channel case (thin devices) for which the PDEs reduce to ODEs. The goal of this problem is to produce analytical solutions based on the underlying PDEs that are rapid to compute (e.g. require solving only a small number of algebraic equations rather than systems of PDEs). Guided by asymptotic analysis, a fast numerical procedure has been developed to obtain approximate solutions of the governing PDEs governing MOSFET properties, namely electron density, Fermi potential and electrostatic potential. The approach depends on the channel’s being long enough, and appears accurate in this limit

Influence of Cytomatrix Proteins on Water and on Ions in Cells

This review concerns the influence that cytomatrix proteins have on the motional properties of water and on the major inorganic ions in cells. The techniques we used for study of water in cells and on the cytomatrix proteins include: pulsed NMR of water protons, quench cooled ice crystal imprint size, and osmotic behavior. The technique for study of ions involved use of electron-probe X-ray microanalysis of thin cryosections of cells. The cytomatrix was found to play the major role in determining the extent of hydration water in cells, The amount of hydration water varied greatly between cell types (e.g., lens fiber cells have no detectable bulk water) and varied in the same cell type studied under different states (e.g., unfertilized and fertilized sea urchin eggs). Aggregation of cytomatrix proteins (actin in particular) is a determinant of the extent of hydration water in cells. Hydration water appears not to participate in the ideal osmotic equation of van\u27t Hoff. The ionic content of cells does not accurately predict the chemical activity of the ions in cytoplasm. A major proportion of intracellular K+ and a substantial fraction of Cl- was found to be influenced by the cytomatrix such that their diffusion was impaired. The cytomatrix is responsible for the decreased motional properties of a substantial portion of cellular water and ions

Nitrogen transport in the orchid mycorrhizal symbiosis - further evidence for a mutualistic association.

Mycorrhizas are symbioses integral to the health of plant-based ecosystems (Smith & Read, 2008). In a typical mycorrhizal association, fungi in, or on, plant roots pass soil-acquired inorganic nutrients and water to the plant host. In return, the host transfers excess photosynthate to the fungus