Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after γ-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis

Learning Bodily and Temporal Attention in Protective Movement Behavior Detection

For people with chronic pain, the assessment of protective behavior during physical functioning is essential to understand their subjective pain-related experiences (e.g., fear and anxiety toward pain and injury) and how they deal with such experiences (avoidance or reliance on specific body joints), with the ultimate goal of guiding intervention. Advances in deep learning (DL) can enable the development of such intervention. Using the EmoPain MoCap dataset, we investigate how attention-based DL architectures can be used to improve the detection of protective behavior by capturing the most informative temporal and body configurational cues characterizing specific movements and the strategies used to perform them. We propose an end-to-end deep learning architecture named BodyAttentionNet (BANet). BANet is designed to learn temporal and bodily parts that are more informative to the detection of protective behavior. The approach addresses the variety of ways people execute a movement (including healthy people) independently of the type of movement analyzed. Through extensive comparison experiments with other state-of-the-art machine learning techniques used with motion capture data, we show statistically significant improvements achieved by using these attention mechanisms. In addition, the BANet architecture requires a much lower number of parameters than the state of the art for comparable if not higher performances.Comment: 7 pages, 3 figures, 2 tables, code available, accepted in ACII 201

Oocyte cryopreservation as an adjunct to the assisted reproductive technologies

The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included. See page 2 of PDF for this item.Keith L Harrison, Michelle T Lane, Jeremy C Osborn, Christine A Kirby, Regan Jeffrey, John H Esler and David Mollo

Doppler cooling of gallium atoms: 2. Simulation in complex multilevel systems

This paper derives a general procedure for the numerical solution of the Lindblad equations that govern the coherences arising from multicoloured light interacting with a multilevel system. A systematic approach to finding the conservative and dissipative terms is derived and applied to the laser cooling of gallium. An improved numerical method is developed to solve the time-dependent master equation and results are presented for transient cooling processes. The method is significantly more robust, efficient and accurate than the standard method and can be applied to a broad range of atomic and molecular systems. Radiation pressure forces and the formation of dynamic dark-states are studied in the gallium isotope 66Ga.Comment: 15 pages, 8 figure

Anchors for the Cosmic Distance Scale: the Cepheids U Sgr, CF Cas and CEab Cas

New and existing X-ray, UBVJHKsW(1-4), and spectroscopic observations were analyzed to constrain fundamental parameters for M25, NGC 7790, and dust along their sight-lines. The star clusters are of particular importance given they host the classical Cepheids U Sgr, CF Cas, and the visual binary Cepheids CEa and CEb Cas. Precise results from the multiband analysis, in tandem with a comprehensive determination of the Cepheids' period evolution (dP/dt) from ~140 years of observations, helped resolve concerns raised regarding the clusters and their key Cepheid constituents. Specifically, distances derived for members of M25 and NGC 7790 are 630+-25 pc and 3.40+-0.15 kpc, respectively.Comment: To appear in Astronomy and Astrophysic

Optical constants of uranium plasma Final report

Thermodynamic and optical properties of uranium plasma in proposed gaseous core nuclear rocket

Organizing the innovation process : complementarities in innovation networking

This paper contributes to the developing literature on complementarities in organizational design. We test for the existence of complementarities in the use of external networking between stages of the innovation process in a sample of UK and German manufacturing plants. Our evidence suggests some differences between the UK and Germany in terms of the optimal combination of innovation activities in which to implement external networking. Broadly, there is more evidence of complementarities in the case of Germany, with the exception of the product engineering stage. By contrast, the UK exhibits generally strong evidence of substitutability in external networking in different stages, except between the identification of new products and product design and development stages. These findings suggest that previous studies indicating strong complementarity between internal and external knowledge sources have provided only part of the picture of the strategic dilemmas facing firms

Equivalence of the Siegert-pseudostate and Lagrange-mesh R-matrix methods

Siegert pseudostates are purely outgoing states at some fixed point expanded over a finite basis. With discretized variables, they provide an accurate description of scattering in the s wave for short-range potentials with few basis states. The R-matrix method combined with a Lagrange basis, i.e. functions which vanish at all points of a mesh but one, leads to simple mesh-like equations which also allow an accurate description of scattering. These methods are shown to be exactly equivalent for any basis size, with or without discretization. The comparison of their assumptions shows how to accurately derive poles of the scattering matrix in the R-matrix formalism and suggests how to extend the Siegert-pseudostate method to higher partial waves. The different concepts are illustrated with the Bargmann potential and with the centrifugal potential. A simplification of the R-matrix treatment can usefully be extended to the Siegert-pseudostate method.Comment: 19 pages, 1 figur

Pseudo-Goldstone Boson Effects in Top-Antitop Productions at High Energy Hadron Colliders and Testing Technicolor Models

We study the top quark pair production process p+p(anti-p)-->top+antitop in various kinds of technicolor (TC) models at the Fermilab Tevatron Run II and the CERN LHC. The s-channel neutral pseudo-Goldstone bosons (PGB's) contribute dominately to the production amplitudes from its coupling to the gluons through the triangle loops of techniquarks and the top quark. Cross sections in different TC models with s-channel PGB contributions are calculated. It is shown that the PGB effects can be experimentally tested and different TC models under consideration can be distinguished at the LHC. Therefore, the p+p-->top+antitop process at the LHC provides feasible tests of the TC models.Comment: 10 pages in RevTex and 4 PS-files for the figures. Paramemter range is changed, and some references are added. Version for publication in Phys. Rev.