Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons

Burst firing of substantia nigra dopamine (SN DA) neurons is believed to represent an important teaching signal that instructs synaptic plasticity and associative learning. However, the mechanisms through which synaptic excitation overcomes the limiting effects of somatic Ca2+-dependent K+ current to generate burst firing are controversial. Modeling studies suggest that synaptic excitation sufficiently amplifies oscillatory dendritic Ca2+ and Na+ channel currents to lead to the initiation of high-frequency firing in SN DA neuron dendrites. To test this model, visually guided compartment-specific patch-clamp recording and ion channel manipulation were applied to rodent SN DA neurons in vitro. As suggested previously, the axon of SN DA neurons was typically found to originate from a large-diameter dendrite that was proximal to the soma. However, in contrast to the predictions of the model, (1) somatic current injection generated firing that was similar in frequency and form to burst firing in vivo, (2) the efficacy of glutamatergic excitation was inversely related to the distance of excitation from the axon, (3) pharmacological blockade or genetic deletion of Ca2+ channels did not prevent high-frequency firing, (4) action potential bursts were invariably detected first at sites that were proximal to the axon, and (5) pharmacological blockade of Na+ channels in the vicinity of the axon/soma but not dendritic excitation impaired burst firing. Together, these data suggest that SN DA neurons integrate their synaptic input in a more conventional manner than was hypothesized previously

Representing older people: towards meaningful images of the user in design scenarios

Designing for older people requires the consideration of a range of difficult and sometimes highly personal design problems. Issues such as fear, loneliness, dependency, and physical decline may be difficult to observe or discuss in interviews. Pastiche scenarios and pastiche personae are techniques that employ characters to create a space for the discussion of new technological developments and as a means to explore user experience. This paper argues that the use of such characters can help to overcome restrictive notions of older people by disrupting designers' prior assumptions. In this paper, we reflect on our experiences using pastiche techniques in two separate technology design projects that sought to address the needs of older people. In the first case pastiche scenarios were developed by the designers of the system and used as discussion documents with users. In the second case, pastiche personae were used by groups of users themselves to generate scenarios which were scribed for later use by the design team. We explore how the use of fictional characters and settings can generate new ideas and undermine rhetorical devices within scenarios that attempt to fit characters to the technology, rather than vice versa. To assist in future development of pastiche techniques in designing for older people, we provide an array of fictional older characters drawn from literary and popular culture.</p

Noise-induced dynamical transition in systems with symmetric absorbing states

We investigate the effect of noise strength on the macroscopic ordering dynamics of systems with symmetric absorbing states. Using an explicit stochastic microscopic model, we present evidence for a phase transition in the coarsening dynamics, from an Ising-like to a voter-like behavior, as the noise strength is increased past a nontrivial critical value. By mapping to a thermal diffusion process, we argue that the transition arises due to locally-absorbing states being entered more readily in the high-noise regime, which in turn prevents surface tension from driving the ordering process.Comment: v2 with improved introduction and figures, to appear in PRL. 4 pages, 4 figure

The Grand-Canonical Asymmetric Exclusion Process and the One-Transit Walk

The one-dimensional Asymmetric Exclusion Process (ASEP) is a paradigm for nonequilibrium dynamics, in particular driven diffusive processes. It is usually considered in a canonical ensemble in which the number of sites is fixed. We observe that the grand-canonical partition function for the ASEP is remarkably simple. It allows a simple direct derivation of the asymptotics of the canonical normalization in various phases and of the correspondence with One-Transit Walks recently observed by Brak et.al.Comment: Published versio

Random Networks with Tunable Degree Distribution and Clustering

We present an algorithm for generating random networks with arbitrary degree distribution and Clustering (frequency of triadic closure). We use this algorithm to generate networks with exponential, power law, and poisson degree distributions with variable levels of clustering. Such networks may be used as models of social networks and as a testable null hypothesis about network structure. Finally, we explore the effects of clustering on the point of the phase transition where a giant component forms in a random network, and on the size of the giant component. Some analysis of these effects is presented.Comment: 9 pages, 13 figures corrected typos, added two references, reorganized reference

Approach to Asymptotic Behaviour in the Dynamics of the Trapping Reaction

We consider the trapping reaction A + B -> B in space dimension d=1, where the A and B particles have diffusion constants D_A, D_B respectively. We calculate the probability, Q(t), that a given A particle has not yet reacted at time t. Exploiting a recent formulation in which the B particles are eliminated from the problem we find, for t -> \infty, $Q(t) \sim \exp[-(4/\sqrt{\pi})(\rho^2 D_Bt)^{1/2} - (C \rho^2 D_A t)^{1/3} + ...]$, where $\rho$ is the density of B particles and $C \propto D_A/D_B$ for $D_A/D_B << 1$.Comment: 8 pages, 2 figures; minor change

Single microwave photon detection in the micromaser

High efficiency single photon detection is an interesting problem for many areas of physics, including low temperature measurement, quantum information science and particle physics. For optical photons, there are many examples of devices capable of detecting single photons with high efficiency. However reliable single photon detection of microwaves is very difficult, principally due to their low energy. In this paper we present the theory of a cascade amplifier operating in the microwave regime that has an optimal quantum efficiency of 93%. The device uses a microwave photon to trigger the stimulated emission of a sequence of atoms where the energy transition is readily detectable. A detailed description of the detector's operation and some discussion of the potential limitations of the detector are presented.Comment: 8 pages, 5 figure

Lee-Yang zeros and phase transitions in nonequilibrium steady states

We consider how the Lee-Yang description of phase transitions in terms of partition function zeros applies to nonequilibrium systems. Here one does not have a partition function, instead we consider the zeros of a steady-state normalization factor in the complex plane of the transition rates. We obtain the exact distribution of zeros in the thermodynamic limit for a specific model, the boundary-driven asymmetric simple exclusion process. We show that the distributions of zeros at the first and second order nonequilibrium phase transitions of this model follow the patterns known in the Lee-Yang equilibrium theory.Comment: 4 pages RevTeX4 with 4 figures; revised version to appear in Phys. Rev. Let

Phase transition in a non-conserving driven diffusive system

An asymmetric exclusion process comprising positive particles, negative particles and vacancies is introduced. The model is defined on a ring and the dynamics does not conserve the number of particles. We solve the steady state exactly and show that it can exhibit a continuous phase transition in which the density of vacancies decreases to zero. The model has no absorbing state and furnishes an example of a one-dimensional phase transition in a homogeneous non-conserving system which does not belong to the absorbing state universality classes

An introduction to phase transitions in stochastic dynamical systems

We give an introduction to phase transitions in the steady states of systems that evolve stochastically with equilibrium and nonequilibrium dynamics, the latter defined as those that do not possess a time-reversal symmetry. We try as much as possible to discuss both cases within the same conceptual framework, focussing on dynamically attractive `peaks' in state space. A quantitative characterisation of these peaks leads to expressions for the partition function and free energy that extend from equilibrium steady states to their nonequilibrium counterparts. We show that for certain classes of nonequilibrium systems that have been exactly solved, these expressions provide precise predictions of their macroscopic phase behaviour.Comment: Pedagogical talk contributed to the "Ageing and the Glass Transition" Summer School, Luxembourg, September 2005. 12 pages, 8 figures, uses the IOP 'jpconf' document clas