6,140 research outputs found
Understanding Student Computational Thinking with Computational Modeling
Recently, the National Research Council's framework for next generation
science standards highlighted "computational thinking" as one of its
"fundamental practices". 9th Grade students taking a physics course that
employed the Modeling Instruction curriculum were taught to construct
computational models of physical systems. Student computational thinking was
assessed using a proctored programming assignment, written essay, and a series
of think-aloud interviews, where the students produced and discussed a
computational model of a baseball in motion via a high-level programming
environment (VPython). Roughly a third of the students in the study were
successful in completing the programming assignment. Student success on this
assessment was tied to how students synthesized their knowledge of physics and
computation. On the essay and interview assessments, students displayed unique
views of the relationship between force and motion; those who spoke of this
relationship in causal (rather than observational) terms tended to have more
success in the programming exercise.Comment: preprint to submit to PERC proceedings 201
Recent La Plata basin drought conditions observed by satellite gravimetry
The Gravity Recovery and Climate Experiment (GRACE) provides quantitative
measures of terrestrial water storage (TWS) change. GRACE data show a
significant decrease in TWS in the lower (southern) La Plata river basin of
South America over the period 2002-2009, consistent with recognized drought
conditions in the region. GRACE data reveal a detailed picture of temporal and
spatial evolution of this severe drought event, which suggests that the drought
began in lower La Plata in around austral spring 2008 and then spread to the
entire La Plata basin and peaked in austral fall 2009. During the peak, GRACE
data show an average TWS deficit of ~12 cm (equivalent water layer thickness)
below the 7 year mean, in a broad region in lower La Plata. GRACE measurements
are consistent with accumulated precipitation data from satellite remote
sensing and with vegetation index changes derived from Terra satellite
observations. The Global Land Data Assimilation System model captures the
drought event but underestimates its intensity. Limited available
groundwater-level data in southern La Plata show significant groundwater
depletion, which is likely associated with the drought in this region.
GRAC-observed TWS change and precipitation anomalies in the studied region
appear to closely correlate with the ENSO climate index, with dry and wet
seasons corresponding to La Ni\~na and El Ni\~no events, respectively
The Robertson v. Princeton Case: Too Important to Be Left to the Lawyers
Offers comments from eleven contributors on the Robertson family's donor rights suit against the Woodrow Wilson School of Public and International Affairs for violation of donor intent. Explores its effects on and implications for the nonprofit sector
Beam alignment techniques based on the current multiplication effect in photoconductors Third summary technical progress report, 15 Nov. 1966 - 15 Oct. 1967
Beam alignment techniques developed for infrared sensitive single crystal germanium to study multiplication effect in photoconductor
Hypersonic simulations using open-source CFD and DSMC solvers
Hypersonic hybrid hydrodynamic-molecular gas flow solvers are required to satisfy the two essential requirements of any high-speed reacting code, these being physical accuracy and computational efficiency. The James Weir Fluids Laboratory at the University of Strathclyde is currently developing an open-source hybrid code which will eventually reconcile the direct simulation Monte-Carlo method, making use of the OpenFOAM application called dsmcFoam, and the newly coded open-source two-temperature computational fluid dynamics solver named hy2Foam. In conjunction with employing the CVDV chemistry-vibration model in hy2Foam, novel use is made of the QK rates in a CFD solver. In this paper, further testing is performed, in particular with the CFD solver, to ensure its efficacy before considering more advanced test cases. The hy2Foam and dsmcFoam codes have shown to compare reasonably well, thus providing a useful basis for other codes to compare against
Structural and magnetic characterization of the complete delafossite solid solution (CuAlO2){1-x}(CuCrO2){x}
We have prepared the complete delafossite solid solution series between
diamagnetic CuAlO2 and the t2g^3 frustrated antiferromagnet CuCrO2. The
evolution with composition x in CuAl(1-x)Cr(x)O2 of the crystal structure and
magnetic properties has been studied and is reported here. The room-temperature
unit cell parameters follow the Vegard law and increase with x as expected. The
effective moment is equal to the Cr^3+ spin-only S = 3/2 value throughout the
entire solid solution. Theta is negative, indicating that the dominant
interactions are antiferromagnetic, and its magnitude increases with Cr
substitution. For dilute Cr compositions, J_BB was estimated by mean-field
theory to be 2.0 meV. Despite the sizable Theta, long-range antiferromagnetic
order does not develop until very large x, and is preceeded by glassy behavior.
Data presented here, and that on dilute Al-substitution from Okuda et al.,
suggest that the reduction in magnetic frustration due to the presence of
non-magnetic Al does not have as dominant an effect on magnetism as chemical
disorder and dilution of the magnetic exchange. For all samples, the 5 K
isothermal magnetization does not saturate in fields up to 5 T and minimal
hysteresis is observed. The presence of antiferromagnetic interactions is
clearly evident in the sub-Brillouin behavior with a reduced magnetization per
Cr atom. An inspection of the scaled Curie plot reveals that significant
short-range antiferromagnetic interactions occur in CuCrO2 above its Neel
temperature, consistent with its magnetic frustration. Uncompensated
short-range interactions are present in the Al-substituted samples and are
likely a result of chemical disorder
Rationality as the Rule of Reason
The demands of rationality are linked both to our subjective normative perspective (given that rationality is a person-level concept) and to objective reasons or favoring relations (given that rationality is non-contingently authoritative for us). In this paper, I propose a new way of reconciling the tension between these two aspects: roughly, what rationality requires of us is having the attitudes that correspond to our take on reasons in the light of our evidence, but only if it is competent. I show how this view can account for structural rationality on the assumption that intentions and beliefs as such involve competent perceptions of downstream reasons, and explore various implications of the account
Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.The interaction of IGF-II with the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF-1R) has recently been identified as potential therapeutic target for the treatment of cancer. Understanding the interactions of IGF-II with these receptors is required for the development of potential anticancer therapeutics. This work describes an efficient convergent synthesis of native IGF-II and two nonnative IGF-II analogues with coumarin fluorescent probes incorporated at residues 19 and 28. These fluorescent analogues bind with nanomolar affinities to the IGF-1R and are suitable for use in fluorescence resonance energy transfer (FRET) studies. From these studies the F19Cou IGF-II and F28Cou IGF-II proteins were identified as good probes for investigating the binding interactions of IGF-II with the IGF-1R and its other high affinity binding partners
Cost-Effective Use of Silver Dressings for the Treatment of Hard-to-Heal Chronic Venous Leg Ulcers
Aim
To estimate the cost-effectiveness of silver dressings using a health economic model based on time-to-wound-healing in hard-to-heal chronic venous leg ulcers (VLUs).
Background
Chronic venous ulceration affects 1–3% of the adult population and typically has a protracted course of healing, resulting in considerable costs to the healthcare system. The pathogenesis of VLUs includes excessive and prolonged inflammation which is often related to critical colonisation and early infection. The use of silver dressings to control this bioburden and improve wound healing rates remains controversial.
Methods
A decision tree was constructed to evaluate the cost-effectiveness of treatment with silver compared with non-silver dressings for four weeks in a primary care setting. The outcomes: ‘Healed ulcer’, ‘Healing ulcer’ or ‘No improvement’ were developed, reflecting the relative reduction in ulcer area from baseline to four weeks of treatment. A data set from a recent meta-analysis, based on four RCTs, was applied to the model.
Results
Treatment with silver dressings for an initial four weeks was found to give a total cost saving (£141.57) compared with treatment with non-silver dressings. In addition, patients treated with silver dressings had a faster wound closure compared with those who had been treated with non-silver dressings.
Conclusion
The use of silver dressings improves healing time and can lead to overall cost savings. These results can be used to guide healthcare decision makers in evaluating the economic aspects of treatment with silver dressings in hard-to-heal chronic VLUs
Onset of Surface-Tension-Driven Benard Convection
Experiments with shadowgraph visualization reveal a subcritical transition to
a hexagonal convection pattern in thin liquid layers that have a free upper
surface and are heated from below. The measured critical Marangoni number (84)
and observation of hysteresis (3%) agree with theory. In some experiments,
imperfect bifurcation is observed and is attributed to deterministic forcing
caused in part by the lateral boundaries in the experiment.Comment: 4 pages. The RevTeX file has a macro allowing various styles. The
appropriate style is "mypprint" which is the defaul
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