MicroRNA regulation of CD8+ T cell responses.

MicroRNAs (miRNAs) are a class of short noncoding RNAs that play critical roles in the regulation of a broad range of biological processes. Like transcription factors, miRNAs exert their effects by modulating the expression of networks of genes that operate in common or convergent pathways. CD8+ T cells are critical agents of the adaptive immune system that provide protection from infection and cancer. Here, we review the important roles of miRNAs in the regulation of CD8+ T cell biology and provide perspectives on the broader emerging principles of miRNA function

Alien Registration- Brewer, Ansel D. (Thomaston, Knox County)

https://digitalmaine.com/alien_docs/13014/thumbnail.jp

The Clinical Rationale for the Sentry Bioconvertible Inferior Vena Cava Filter for the Prevention of Pulmonary Embolism

The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection against pulmonary embolism (PE) during transient high-risk periods and then to bioconvert after 60 days after implantation. At the time of bioconversion, the device's nitinol arms retract from the filtering position into the caval wall. Subsequently, the stable stent-like nitinol frame is endothelialized. The Sentry bioconvertible IVC filter has been evaluated in a multicenter investigational-device-exemption pivotal trial (NCT01975090) of 129 patients with documented deep vein thrombosis (DVT) or PE, or at temporary risk of developing DVT or PE, and with contraindications to anticoagulation. Successful filter conversion was observed in 95.7% of patients at 6 months (110/115) and 96.4% at 12 months (106/110). Through 12 months, there were no cases of symptomatic PE. The rationale for development of the Sentry bioconvertible device includes the following considerations: (1) the period of highest risk of PE for the vast majority of patients occurs within the first 60 days after an index event, with most of the PEs occurring in the first 30 days; (2) the design of retrievable IVC filters to support their removal after a transitory high-PE-risk period has, in practice, been associated with insecure filter dynamics and time-dependent complications including tilting, fracture, embolization, migration, and IVC perforation; (3) most retrievable IVC filters are placed for temporary protection, but for a variety of reasons they are not removed in any more than half of implanted patients, and when removal is attempted, the procedure is not always successful even with advanced techniques; and (4) analysis of Medicare hospital data suggests that payment for the retrieval procedure does not routinely compensate for expense. The Sentry device is not intended for removal after bioconversion. In initial clinical use, complications have been limited. Long-term results for the Sentry bioconvertible IVC filter are anticipated soon

Enhancing quantum exchanges between two oscillators

We explore the extent to which two quantum oscillators can exchange their quantum states efficiently through a three-level system which can be spin levels of colored centers in solids. High transition probabilities are obtained using Hamiltonian engineering and quantum control techniques. Starting from a weak coupling approximation, we derive conditions on the spin-oscillator interaction Hamiltonian that enable a high fidelity exhange of quanta. We find that these conditions cannot be fulfilled for arbitrary spin-oscillator coupling. To overcome this limitation, we illustrate how a time-dependent control field applied to the three-level system can lead to an effective dynamic that performs the desired exchange of excitation. In the strong coupling regime, an important loss of fidelity is induced by the dispersion of the excitation onto many Fock states of the oscillators. We show that this detrimental effect can be substantially reduced by suitable control fields, which are computed with optimal control numerical algorithms.Comment: 11 figure

Quadratic BSDEs driven by a continuous martingale and application to utility maximization problem

In this paper, we study a class of quadratic Backward Stochastic Differential Equations (BSDEs) which arises naturally when studying the problem of utility maximization with portfolio constraints. We first establish existence and uniqueness results for such BSDEs and then, we give an application to the utility maximization problem. Three cases of utility functions will be discussed: the exponential, power and logarithmic ones

Method of providing a lunar habitat from an external tank

A lunar habitat is provided by placing an external tank of an orbiter in a low Earth orbit where the hydrogen tank is separated from the intertank and oxygen tank which form a base structure. The base structure is then outfitted with an air lock, living quarters, a thermal control system, an environmental control and life support system, and a propulsion system. After the mounting of an outer sheath about the base structure to act as a micrometeoroid shield, the base structure is propelled to a soft landing on the moon. The sheath is mounted at a distance from the base structure to provide a space therebetween which is filled with regolith after landing. Conveniently, a space station is used to outfit the base structure. Various elements of the oxygen tank and intertank are used in outfitting