The survey and mapping of sand-boil landforms related to the Emilia 2012 earthquakes: preliminary results.

Sand boils, which are also known as sand blows or sand volcanoes, are among the most common superficial effects induced by high-magnitude earthquakes. These generally occur in or close to alluvial plains when a strong earthquake (M >5) strikes on a lens of saturated and unconsolidated sand deposits that are constrained between silt-clay layers, where the sediments are converted into a fluid suspension. The liquefaction phenomena requires the presence of saturated and uncompacted sand, and a groundwater table near the ground surface. This geological–geomorphological setting is common and widespread for the Po Plain (Italy). The Po Plain (ca. 46,000 km2) represents 15% of the Italian territory. It hosts a population of about 20 million people (mean density of 450 people/km2) and many infrastructures. Thus, the Po Plain is an area of high vulnerability when considering the liquefaction potential in the case of a strong earthquake. Despite the potential, such phenomena are rarely observed in northern Italy, because strong earthquakes are not frequent in this region; e.g., historical data report soil liquefaction near Ferrara in 1570 (M 5.3) and in Argenta 1624 (M 5.5). In the Emilia quakes of May 20 and 29, 2012, the most widespread coseismic effects were soil liquefaction and ground cracks, which occurred over wide areas in the Provinces of Modena, Ferrara, Bologna, Reggio Emilia and Mantov

The survey and mapping of sand-boil landforms related to the Emilia 2012 earthquakes: preliminary results.

Sand boils, which are also known as sand blows or sand volcanoes, are among the most common superficial effects induced by high-magnitude earthquakes. These generally occur in or close to alluvial plains when a strong earthquake (M >5) strikes on a lens of saturated and unconsolidated sand deposits that are constrained between silt-clay layers, where the sediments are converted into a fluid suspension. The liquefaction phenomena requires the presence of saturated and uncompacted sand, and a groundwater table near the ground surface. This geological\u2013geomorphological setting is common and widespread for the Po Plain (Italy). The Po Plain (ca. 46,000 km2) represents 15% of the Italian territory. It hosts a population of about 20 million people (mean density of 450 people/km2) and many infrastructures. Thus, the Po Plain is an area of high vulnerability when considering the liquefaction potential in the case of a strong earthquake. Despite the potential, such phenomena are rarely observed in northern Italy, because strong earthquakes are not frequent in this region; e.g., historical data report soil liquefaction near Ferrara in 1570 (M 5.3) and in Argenta 1624 (M 5.5). In the Emilia quakes of May 20 and 29, 2012, the most widespread coseismic effects were soil liquefaction and ground cracks, which occurred over wide areas in the Provinces of Modena, Ferrara, Bologna, Reggio Emilia and Mantov

SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1

BACKGROUND We have previously identified kinase suppressor of ras-1 (KSR1) as a potential regulatory gene in breast cancer. KSR1, originally described as a novel protein kinase, has a role in activation of mitogen-activated protein kinases. Emerging evidence has shown that KSR1 may have dual functions as an active kinase as well as a scaffold facilitating multiprotein complex assembly. Although efforts have been made to study the role of KSR1 in certain tumour types, its involvement in breast cancer remains unknown. METHODS A quantitative mass spectrometry analysis using stable isotope labelling of amino acids in cell culture (SILAC) was implemented to identify KSR1-regulated phosphoproteins in breast cancer. In vitro luciferase assays, co-immunoprecipitation as well as western blotting experiments were performed to further study the function of KSR1 in breast cancer. RESULTS Of significance, proteomic analysis reveals that KSR1 overexpression decreases deleted in breast cancer-1 (DBC1) phosphorylation. Furthermore, we show that KSR1 decreases the transcriptional activity of p53 by reducing the phosphorylation of DBC1, which leads to a reduced interaction of DBC1 with sirtuin-1 (SIRT1); this in turn enables SIRT1 to deacetylate p53. CONCLUSION Our findings integrate KSR1 into a network involving DBC1 and SIRT1, which results in the regulation of p53 acetylation and its transcriptional activity

Acquired Refractory Iron Deficiency Anemia

Anemia is a global health problem affecting one-third of the world population, and half of the cases are due to iron deficiency (ID). Iron deficiency anemia (IDA) is the leading cause of disability in several countries. Although multiple mechanisms may coexist, ID and IDA causes can be classified as i) insufficient iron intake for the body requirement, ii) reduced absorption, and iii) blood losses. Oral iron represents the mainstay of IDA treatment. IDA is defined as "refractory" when the hematologic response after 4 to 6 weeks of treatment with oral iron (an increase of >=1 g/dL of Hb) is absent. The cause of iron-refractory anemia is usually acquired and frequently related to gastrointestinal pathologies, although a rare genetic form called iron-refractory iron deficiency anemia (IRIDA) exists. In some pathological circumstances, either genetic or acquired, hepcidin increases, limiting the absorption in the gut, remobilization, and recycling of iron, thereby reducing iron plasma levels. Indeed, conditions with high hepcidin levels are often under-recognized as iron refractory, leading to inappropriate and unsuccessful treatments. This review provides an overview of the iron refractory anemia underlying conditions, from gastrointestinal pathologies to hepcidin dysregulation and iatrogenic or provoked conditions, and the specific diagnostic and treatment approach

The survey and mapping of sand-boil landformsrelated to the Emilia 2012 earthquakes: preliminary results

In this report, we present preliminary results using methods to map the detailed micro-morphology of some representative liquefaction features that normally disappear for the aforementioned reasons, or that are recorded only in qualitative terms. Field surveys and activities were conducted a few days after the May 20 and 29, 2012, mainshocks (M 5.9, M 5.8, respectively). The surveys were carried out using global position system (GPS) and reflex digital cameras. GPS acquisition (tracklog) was used to record the topographic positions of the features and to automatically geolocate/geotag the numerous digital photos acquired. The field data, geomorphological features, and sand-boil location were loaded into a geodatabase and mapped using geographic information systems (GIS). Photogrammetric surveys were carried out on several sand boils using digital reflex cameras with calibrated 20-mm fixed lenses. To build high resolution digital elevation models (DEMs), images were taken from multiple angles to cover the entire areas of the features of interest

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.

The G protein-coupled receptor kinase-2 (GRK2 or beta-ARK1) regulates beta-adrenergic receptors (beta-ARs) in the heart, and its cardiac expression is elevated in human heart failure (HF). We sought to determine whether myocardial levels and activity of GRK2 could be monitored using white blood cells, which have been used to study cardiac beta-ARs. Moreover, we were interested in determining whether GRK2 levels in myocardium and lymphocytes may be associated with beta-AR dysfunction and HF severity.In myocardial biopsies from explanted failing human hearts, GRK activity was inversely correlated with beta-AR-mediated cAMP production (R(2)=-0.215, P<0.05, n=24). Multiple regression analysis confirmed that GRK activity participates with beta-AR density to regulate catecholamine-sensitive cAMP responses. Importantly, there was a direct correlation between myocardial and lymphocytes GRK2 activity (R(2)=0.5686, P<0.05, n=10). Lymphocyte GRK activity was assessed in HF patients with various ejection fractions (EFs) (n=33), and kinase activity was significantly higher in patients with lower EFs and was higher with increasing NYHA class (P<0.001).Myocardial GRK2 expression and activity are mirrored by lymphocyte levels of this kinase, and its elevation in HF is associated with the loss of beta-AR responsiveness and appears to increase with disease severity. Therefore, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF

Laparoscopic Ovariectomy in Standing Mule Mares

Mules are hybrids bred from the mating of a jack donkey and a horse mare, known for their strength and resistance and still used to work in agriculture. Although they have been for long considered sterile, evidence of estrus cycle has been demonstrated together with abnormal behavior related to ovarian activity. In this study, a bilateral standing laparoscopic ovariectomy technique using the LigaSure technology was applied in 10 mare mules for treating unwanted behavioral patterns. The technique was effectively performed on these animals avoiding the risk of general anesthesia, and the use of the LigaSure technology allowed good hemostasis and reduced surgical time. Owners declared to be satisfied with the resolution of the behavior