Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"

Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad “Debates en torno a la NUEVa Agenda Urbana”, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB –Instituto de Investigación de Vivienda y Hábitat y MGyDH-Maestría en Gestión y Desarrollo Habitacional-1), hemos convidado un espacio que se concretó con potencia en un debate transdisciplinario. Convocó a intelectuales de prestigio internacional, investigadores, académicos y gestores estatales, y en una metodología de innovación articuló las voces académicas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes están trabajando en los desafíos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI

Valoración de bienes de uso público en el modelo contable de entidades de gobierno en Colombia. Una aproximación desde los precios hedónicos

Developed and developing countries have taken the decision to modify their accounting models in response to the approaches proposed by international regulatory bodies. Colombia, in particular, has decided to restructure its Public Accounting Regime taking as reference the international model. Although the Contaduría General de la Nación has established a very complete structure. It has encountered some difficulties in terms of the lack of methodological tools for the measurement of non-market goods. The objective of this paper is to propose a measurement technique to update public assets, by using econometric model for the measurement of public goods with which the availability of public space is determined from hedonic prices. The result achieved will have a methodological tool with a consistent theoretical support. This will be used to update the value of some public assets of the Bogotá capital district, as well as those entities at national and international level that require it. Keyword: public use assets, prices Hedonic, economic valuation, IPSAS. IntroducciónPaíses desarrollados y en vía de desarrollo han modificado su modelo contable como respuesta a los planteamientos de los entes de regulación internacional. Colombia en particular, ha decidido restructurar su Régimen de Contabilidad Pública tomando como referente el modelo internacional. Aunque la Contaduría General de la Nación ha definido una estructura completa, ésta ha presentado algunas dificultades por la falta de herramientas metodológicas para la medición de los bienes de no mercado. El propósito de este artículo es justamente proponer una técnica de medición para actualizar los bienes de uso público, a través de un modelo econométrico que permita determinar la disponibilidad a pagar por el espacio público a partir de precios hedónicos. El resultado alcanzado permite contar con un instrumento metodológico que puede ser utilizado para actualizar el valor de algunos bienes de uso público tanto del distrito capital como de aquellas entidades a nivel nacional e internacional que así lo requieran

A new pollen sequence from southern Iberia suggesting coastal Pleistocene phytodiversity hotspot

This paper presents a palynological study of the archeological layers from the Neanderthal site Abrigo 3 del Complejo del Humo, in southern Spain (Málaga), with the aim of reconstructing the environmental conditions in the vicinity of this hominin site. The Upper Pleistocene vegetation and its variability are described, revealing a high diversity of thermophilous plant taxa throughout the cold dry phases, together with a long-term persistence of woody taxa, including Mediterranean, mesophytes, xerothermics and conifers. With the pollen records of Maytenus senegalensis as an outstanding finding, this study demonstrates the co-existence of temperate, Mediterranean and Ibero-Maghrebian angiosperms on the southern coastal plains of the Iberian Pleistocene where Neanderthals survived for a long time. It is therefore clear that Neanderthals and early Upper Paleolithic modern humans lived in a litoral refugium, which was a propitious environment for maintaining a high biodiversity, including potentially edible plant species. Besides, this coastal refugium offers broad possibilities for hunting, and interpopulational relationships through coastal platforms.The research of this work was funded by the projects MED-REFUGIA-RTI2018-101714-B-I00 (Plan Nacional I + D + I, Spanish Ministry of Economy and Competitiveness) and by the ERC-Starting Grant Proposal No. 805478. The development of this work was supported by Project (CGL-BOS2015-68604-P), funded by: FEDER/Ministry of Science and Innovation - Agencia Estatal de Investigación, Project (PID2019-1049449GB-I00), funded by: FEDER/Ministry of Science and Innovation - Agencia Estatal de Investigación and Fundación Séneca (grant number 20788/PI/18). Reyes Luelmo Lautenschlaeger is funded by a FPU contract (Spanish Ministry of Education, Culture and Sports). FPU16/00676.Peer reviewe

Smart Technologies. SmartTech-IC 2021: Proceedings of the Second International Conference on Smart Technologies, Systems and Applications

This book contains a group of selected papers, which were presented at the Second International Conference on Smart Technologies, Systems and Applications (SmartTech-IC 2021) held on December 1-3, 2021 in Quito, Ecuador. The SmartTech-IC conference aims to attract researchers, scientists and technologists from some of the top companies, universities, research groups, and government agencies from Latin America and around of the world to communicate their research results, inventions and innovative applications in the area of smart science and the most recent smart technological trends. The second edition of SmartTech-IC conference was organized by the Universidad Politécnica Salesiana (Campus Giron), a private institution of higher education with social purposes, nonprofit and co-financed from the Ecuadorian State. The SmartTech-IC conference has been conceived as an academic platform to promote the creation of technical and scientific collaboration networks. The goal of the conference was addressed some relevant topics related to smart technologies, smart systems, smart trends and applications in different domains in the field of computer science and information systems that represent innovation in current society

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking transmission to mosquitoes, making it a potential multistage drug target. We report the optimization of an aspartyl protease binding scaffold and the discovery of potent, orally active PMX inhibitors with in vivo antimalarial efficacy. Incorporation of safety evaluation early in the characterization of PMX inhibitors precluded compounds with a long human half-life (t1/2) to be developed. Optimization focused on improving the off-target safety profile led to the identification ofUCB7362that had an improved in vitro and in vivo safety profile but a shorter predicted humant1/2.UCB7362is estimated to achieve 9 log 10 unit reduction in asexual blood-stage parasites with once-daily dosing of 50 mg for 7 days. This work demonstrates the potential to deliver PMX inhibitors with in vivo efficacy to treat malaria

Examining the accuracy of density functional theory for predicting the thermodynamics of water incorporation into minerals: The hydrates of calcium carbonate

The thermodynamics of water incorporation into calcium carbonate to form hydrates has been computed quantum mechanically using density functional theory (DFT). The structure of both the hydrated and the anhydrous phases are accurately reproduced by pure-DFT, hybrid Hartree–Fock/DFT, and DFT-D2 (long-range empirical correction). However, all of the aforementioned schemes fail to correctly reproduce the experimental energetics for the hydration process. In particular, functionals that provide reliable values for the anhydrous and low water content phases (calcite, aragonite, monohydrocalcite) fail to predict the energetics for the highly hydrated phase (ikaite) and vice versa, such that a comprehensive reliable study cannot be performed with a single method. Given that the available C6 parameters for the dispersive contributions in augmented DFT schemes typically are derived for atoms in molecular environments, we have refitted this parameter specifically for carbonates based on the relative enthalpy of aragonite versus calcite. This leads to a major improvement of the computed relative enthalpy and free energy of the anhydrous and hydrated phases.This paper therefore confirms that (i) the most widely used DFT schemes are unable to predict the energetics of reactions involving systems with very different structures or those that are characterized by different kinds of interactions; (ii) van der Waals interactions are important even in systems dominated by strong ionic and covalent interactions; (iii) using literature C6 parameters that have been derived for molecular systems can lead to significant errors for solid systems; and (iv) PBE-type functionals specifically tailored for solids are able to predict at least the stability order of two polymorphs and the sign of ?H and ?G of a reaction, despite the fact that long-range correlation effects are not explicitly included in their formulation