La implementación de la calidad, herramienta para el éxito

En el desarrollo de éste ensayo se analiza cómo en una Institución Prestadora de Servicios de Salud (IPS), la implementación de políticas basadas en el modelo de la calidad permite que una empresa pequeña y muy organizada sea más competitiva y exitosa en su medio. Así mismo, se estudian algunas situaciones reales en donde la IPS implementa día a día conceptos como planeación y mejora continua. El análisis permitió determinar y reconocer la importancia de tener políticas claras plasmadas en procesos y procedimientos como promesa básica de las organizaciones que buscan obtener un factor diferencial en un entorno tan competitivo como el de hoy, y por otro lado identificar la estrategia de implementación de la calidad, como una herramienta clave para la productividad de la organizació

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population