Upper Paleozoic Dikes of the Marão Mountain (Northern Portugal); results of intra orogenic Extension?

[Abstract] In the Marão mountain occur hercynian mafic veins cutting the Schistose Formation of the Landeilian age. The geochemistry of these rocks present high concentrations on Ti ,P, Zr, Nb, Ba, and REE (Ti O2= 1.23-1,39 %, P2O5= 1.32-1,60 %, Zr = 565-641 ppm, Nb= 33-46 ppm, Ba = 2531-3219 ppm, ΣREE = 295-430 ppm) and indicate significant REE fractionation (CeN/ Y bN= 10.46) similar to that reported for alkaline mafic rocks. These characteristics and their patterns in THOMPSON (1984) diagram are typical of alkaline rocks. The dikes intrusion occurred in a late stage of the tectonic evolution of the Centro-Iberian autochthon prior to the granitic magmatic phase. Their intrusion was facilitated, either by the reorientation of the stress field due to the emplacement of the NW Iberian nappe complex or local extensions common in transpressive regimes. This geodynamical context could produce the generation of alkaline magmatism due to partial melting of the upper mantle, induced by adiabatical decompression in the major crustal NW-SE shear zones

Análise ergonômica do posto de trabalho de uma oficina de órteses e próteses para reabilitação de pessoas com deficiência

A presente pesquisa foi elaborada com o objetivo de averiguar as condições ergonômicas de um posto de trabalho em uma oficina de conformação de órteses e próteses. Essa pesquisa se caracteriza por uma pesquisa descritiva de abordagem qualitativa. Apresenta como procedimentos técnicos a pesquisa bibliográfica e o estudo de caso, apoiados por visitas técnicas e entrevistas semi estruturadas. A análise do posto de trabalho foi desenvolvido a partir da utilização da Análise Ergonômica do Trabalho (AET) na empresa Ortonew, especializada na comercialização e confecção de órteses e próteses. Os resultados diagnosticaram pontos positivos e negativos do posto de trabalho observado. Pontos positivos: alternância entre trabalho sentado e trabalho em pé, permissão de pausas/intervalos, horário de trabalho relativamente flexível, música ambiente e clima organizacional amistoso. Os principais pontos negativos identificados são relacionados ao mobiliário (bancada e cadeira), às posturas, à ausência de uso de equipamentos de proteção individual (EPIs) e uso de instrumentos perigosos

Maní tostado con miel y maní tostado de Argentina. Análisis químico y sensorial

The objective of this work was to characterize the chemical and sensory aspects of Honey Roasted (HRP) and Roasted Peanuts (RP). These products were evaluated for sensory analysis: overall acceptance using a consumer test and a descriptive analysis using a trained panel. Percentages of protein, oil, carbohydrate and ash was analyzed in HRP and RP. The contents of carbohydrate, oil and protein in HRP were 28.22%, 45.56% and 21.06%, respectively. RP showed higher percentages of lipids and protein and lower percentages of carbohydrate content than HRP. The total energetic value was lower in HRP. Values of 8 (like very much) were chosen by a higher number of consumer panelist for HRP while values of 6 (like slightly) were found in a higher proportion for RP. The trained panel described 11 attributes: brown color, roughness, roasted peanutty, oxidized, cardboard, sweet, salty, bitter, sour, hardness and crunchiness. The roasted peanutty intensity in RP was higher than in HRP. The intensities of roughness, sweet and salty in HRP were higher than in RP.El objetivo del trabajo fue caracterizar química y sensorialmente al Maní Tostado con Miel (MTM) y Maní Tostado (MT). Estos dos productos fueron evaluados sensorialmente analizando su aceptabilidad por parte de consumidores (test de aceptabilidad) y sus atributos sensoriales por el uso de un panel de jueces entrenados (prueba descriptiva). Por otra parte se describió la composición química porcentual: porcentajes de proteínas, aceites, hidratos de carbonos y cenizas. Los contenidos de hidratos de carbonos, aceites y proteínas en MTM fueron de 28,22%, 45.56% y 21,06%. MT presentó mayores porcentajes de lípidos y proteínas y menor contenido de hidratos de carbono que MTM. El valor energético total de MTM es levemente menor que en MT. La aceptabilidad de los productos mostró mayor número de consumidores que le asignaron un valor de 8 ( me gusta mucho) dentro de una escala hedónica de 9 puntos a MTM y de 6 (me gusta ligeramente) a MT. El panel de jueces entrenados describieron 11 atributos: color marrón, rugosidad, sabores a maní tostado, oxidado y cartón, dulce, salado, amargo, ácido, dureza y crujiente. La intensidad del atributo maní tostado fue mayor en MT que en MTM mientras que este último presentó mayor intensidad en los atributos rugosidad, dulce y salado

Protección de la Heparina a las células B- pancreáticas frente a radicales libres de Oxígeno.

La diabetes autoinmune tipo 1 se caracteriza por la invasión de células mononucleares en los islotes pancreáticos, destruyendo así las células beta productoras de insulina. Se ha visto que in vivo la destrucción autoinmune de los islotes se asocia con la producción de heparanasa, la cual degrada heparán sulfato (molécula imprescindible para la supervivencia de los islotes) y se permite la entrada de las células inmunitarias que atacarán los islotes beta pancreáticos. Se han obtenido resultados mediante la adición de concentraciones conocidas de heparina, la cual confiere una protección extra frente a radicales libres de oxígeno y como consecuencia hay una disminución de la mortalidad celular.A través de tres líneas celulares distintas se ha llevado a cabo el experimento. Primeramente con Rinm5F productora de insulina y somatostatina, con células Ins capaces de responder al estímulo de glucosa produciendo y secretando insulina y finalmente con fibroblastos. El experimento se basa en dejar crecer las cepas celulares en un número determinado de flacs según el tratamiento. Se añade heparina a una concentración conocida y establecida anteriormente y al día siguiente con una concentración exacta de agua oxigenada (aporta los radicales libres de oxígeno) se la añadimos al cultivo. Recogemos las células y gracias al ioduro de propidio con concentración 1 mg/ml marcamos las células muertas para así poder comprobar el porcentaje de supervivencia celular que le ha conferido la heparina a cada línea celular. Procedemos a realizar el contaje con el citómetro que indica el % de muerte celular, ya que el ioduro de propidio es un agente intercalante que se une a los ácidos nucleicos. Esta molécula fluorescente se utiliza para evaluar la viabilidad celular o el contenido de ADN en las células. Se puede utilizar para diferenciar células necróticas, apoptóticas o vivas.Los resultados obtenidos con las líneas celulares Rinm5F y las Ins nos muestran que a bajas concentraciones de agua oxigenada y con heparina, efectivamente hay protección ya que la muerte celular se reduce de un 10 a un 15%. En cambio con los fibroblastos no vemos protección a ninguna de las concentraciones establecidas, resultado que ya esperábamos en nuestra hipótesis inicial. Estos resultados sólo son el inicio de un largo estudio, ya que  primero se ajustan las concentraciones a trabajar con radicales libres de oxígeno, pero en un  futuro el estudio se realizará también con radicales de nitrógeno

Closed circuits : kinship, neighborhood and incarceration in urban Portugal

The notion that prisons are a ‘world apart’, with their walls severing prisoners from their external relationships, and incarceration an interruption, ‘time away’ spent in a separate social universe, has provided an adequate framework for understanding the social realities of imprisonment in the past. But it has also created an analytical dead angle that prevents us from identifying the ramifying social effects of concentrated incarceration upon both the prison and heavily penalized lower-class neighborhoods. This article addresses these effects with data from an ethnographic revisit of a major women’s prison in Portugal, where the recomposition of the inmate population that has accompanied the rapid inflation of the country’s carceral population is especially pronounced and entails the activation of wide-ranging carceralized networks bringing kinship and neighborhood into the prison as well as the prison into the domestic world. The analysis focuses on the ways whereby these constellations have transformed the experience of confinement and the texture of correctional life, calling for a reconsideration of the theoretical status of the prison as a ‘total institution’ and for exploring anew the boundary that separates it (or not) from outside worlds.Wenner-Gren Foundation for Anthropological Research

Phase I clinical trial in healthy adults of a nasal vaccine candidate containing recombinant hepatitis B surface and core antigens

SummaryBackgroundThe nasal vaccine candidate (NASVAC), comprising hepatitis B virus (HBV) surface (HBsAg) and core antigens (HBcAg), has been shown to be highly immunogenic in animal models.MethodsA phase I double-blinded, placebo-controlled randomized clinical trial was carried out in 19 healthy male adults with no serologic markers of immunity/infection to HBV. This study was aimed at exploring the safety and immunogenic profile of nasal co-administration of both HBV recombinant antigens. The trial was performed according to Good Clinical Practice guidelines. Participants ranged in age from 18 to 45 years and were randomly allocated to receive a mixture of 50μg HBsAg and 50μg HBcAg or 0.9% physiologic saline solution, as a placebo, via nasal spray in a five-dose schedule at 0, 7, 15, 30, and 60 days. A total volume of 0.5ml was administered in two dosages of 125μl per nostril. Adverse events were actively recorded 1h, 6h, 12h, 24h, 48h, 72h, 7 days and 30 days after each dose. Anti-HBs and anti-HBc titers were evaluated using corresponding ELISA kits at days 30 and 90.ResultsThe vaccine candidate was safe and well tolerated. Adverse reactions included sneezing (34.1%), rhinorrhea (12.2%), nasal stuffiness (9.8%), palate itching (9.8%), headache (9.8%), and general malaise (7.3%). These reactions were all self-limiting and mild in intensity. No severe or unexpected events were recorded during the trial. The vaccine elicited anti-HBc seroconversion in 100% of subjects as early as day 30 of the immunization schedule, while a seroprotective anti-HBs titer (≥10IU/l) was at a maximum at day 90 (75%). All subjects in the placebo group remained seronegative during the trial.ConclusionThe HBsAg–HBcAg vaccine candidate was safe, well tolerated and immunogenic in this phase I study in healthy adults. To our knowledge, this is the first demonstration of safety and immunogenicity for a nasal vaccine candidate comprising HBV antigens

Present and future tradeoffs between biodiversity, ecosystem services and human well-being in tropical Latin America.

Tropical forests are critical for the maintenance of biodiversity, the mitigation of climate change, this assets has to be in line with the upkeep of the livelihood of rural populations that live with them. Yet, tropical areas have been and still are transformed under the pressure imposed by the production of commodities for global markets. In order to assess the challenges in balancing these multiple needs of tropical areas, we modeled biodiversity change, ecosystem services and human well-being under current conditions and into three contrasting future scenarios (low and high climate forcing, conventional and sustainable development) for Mexico, Brazil and Bolivia. We aimed to answer the following questions: 1- What is the relationship between ecosystem integrity, as an indicator of biodiversity, and ecosystem services? 2- What is the nature of tradeoffs between biodiversity, ecosystem services and human well-being? 3- What policies can contribute to better navigate these tradeoffs

Paleobiology of titanosaurs: reproduction, development, histology, pneumaticity, locomotion and neuroanatomy from the South American fossil record

Fil: García, Rodolfo A.. Instituto de Investigación en Paleobiología y Geología. Museo Provincial Carlos Ameghino. Cipolletti; ArgentinaFil: Salgado, Leonardo. Instituto de Investigación en Paleobiología y Geología. General Roca. Río Negro; ArgentinaFil: Fernández, Mariela. Inibioma-Centro Regional Universitario Bariloche. Bariloche. Río Negro; ArgentinaFil: Cerda, Ignacio A.. Instituto de Investigación en Paleobiología y Geología. Museo Provincial Carlos Ameghino. Cipolletti; ArgentinaFil: Carabajal, Ariana Paulina. Museo Carmen Funes. Plaza Huincul. Neuquén; ArgentinaFil: Otero, Alejandro. Museo de La Plata. Universidad Nacional de La Plata; ArgentinaFil: Coria, Rodolfo A.. Instituto de Paleobiología y Geología. Universidad Nacional de Río Negro. Neuquén; ArgentinaFil: Fiorelli, Lucas E.. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica. Anillaco. La Rioja; Argentin