Análise morfológica de três tipos de limpeza em feridas potencialmente infectadas - estudo experimental em ratos wistar

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Dapartamento de Clínica Cirúrgica

Dermoscopy in nail psoriasis

The authors report on their experience with the use of dermoscopy in nail psoriasis and describe their findings with this diagnostic tool.Os autores relatam sua experiência no uso da dermatoscopia na psoríase ungueal e descrevem os achados dessa ferramenta diagnóstica.Santa Casa de São Paulo Clínica de dermatologiaUniversidade de BolonhaHospital do Servidor Público do Estado de São Paulo Clínica de dermatologiaUniversidade Federal de São Paulo (UNIFESP) departamento de dermatologiaUNIFESP, Depto. de dermatologiaSciEL

Protective effect of the probiotic Lactobacillus acidophilus ATCC 4356 in BALB/c mice infected with Toxocara canis

Human toxocariasis consists of chronic tissue parasitosis that is difficult to treat and control. This study aimed to evaluate the action of the probiotic Lactobacillus acidophilus ATCC 4356 on larvae of Toxocara canis and the effect of IFN-γ cytokine on parasite-host in vivo (1.109 CFU) and in vitro (1.106, 1.107, 1.108, 1.109 CFU) interactions. Four groups of six BALB/c mice were formed: G1 - L. acidophilus supplementation and T. canis infection; G2 - T. canis infection; G3 - L. acidophilus supplementation; and G4 - PBS administration. Mice were intragastrically suplemented with probiotics for 15 days before inoculation and 48 h after inoculation with 100 T. canis eggs. The inoculation of T. canis was also perfomed intragastrically. The recovery of larvae took place through digestion of liver and lung tissues; the evaluation of IFN-γ gene transcription in leukocytes was performed by qPCR. The in vitro test consisted of incubating the probiotic with T. canis larvae. The supplementation of probiotics produced a reduction of 57.7% (p = 0.025) in the intensity of infection of T. canis larvae in mice, whereas in the in vitro test, there was no larvicidal effect. In addition, a decrease in the IFN-γ gene transcription was observed in both, T. canis-infected and uninfected mice, regardless of whether or not they received supplementation. The probiotic L. acidophilus ATCC 4356 reduced T. canis infection intensity in mice, however, the probiotic did not have a direct effect on larvae, demonstrating the need of interaction with the host for the beneficial effect of the probiotic to occur. Yet, the proinflammatory cytokine IFN-γ did not apparently contributed to the observed beneficial effect of probiotics

Nail involvement in epidermolysis bullosa

Nail abnormalities are a common feature in most subtypes of epidermolysis bullosa (EB), and they recently have been included among the criteria for scoring EB severity. Trauma undoubtedly contributes to the development of nail dystrophy, and for this reason the great toenails often are affected more severely. The nail abnormalities may be the first or the only symptom of EB. Nail abnormalities observed in EB are not specific or pathognomonic, as they result from nail bed and matrix scarring. The spectrum of clinical severity is large, and nail abnormalities may cause severe disability or just be a mild cosmetic problem. This article reviews the nail abnormalities observed in EB

Quality of life in alopecia areata

Alopecia areata is a recurrent, nonscarring type of hair loss; it is an autoimmune disease mediated by T lymphocytes, often resistant to multiple therapies. The aim of the study was to evaluate the quality of life in people with alopecia areata. 142 people with alopecia areata were the subjects of our study. The quality of life was measured using a questionnaire voluntarily and anonymously filled in by the patients. The questionnaire contains 21 items. Each patient is asked the following: to state the level of physical and psychological discomfort caused by alopecia areata; the influence that alopecia areata has over their self esteem; their expected consistency and faith in performing the suggested medical treatment; the esthetic perception they have of themselves; limitations due to emotional problems; social functioning; pain, energy/fatigue; emotional well-being. Each question is answered on a 100-point rating scale, with higher scores indicating worse quality of life. Alopecia areata negatively affect quality of life. Patients with alopecia areata have high depression and anxiety levels, social avoidance and low self-esteem. We found that 84% of the patients studied stated that alopecia areata causes noticeable discomfort in their lives. However, the data is more evident in females (66%) compared to males (34%). This outcome suggests that psychological support, in addition to proper alopecia areata treatment, could help in eliminating the social and individual distress caused by hair loss

Você conhece esta síndrome? Do you know this syndrome?

Paquidermoperiostose é genodermatose autossômica dominante rara, que afeta pele e ossos, porém sua prevalência e incidência permanecem desconhecidas. Ocorre predominantemente em homens, que também mostram fenótipo mais grave da doença. Descrevese o caso de paciente do sexo masculino, de 60 anos.<br>Pachydermoperiostosis is a rare autosomal dominant genodermatosis characterized by bone and cutaneous involvement, even though its prevalence and incidence are ignored. It occurs predominantly in men, which present a more serious clinical presentation. We report a case of a 60-year-old man with this disease

Erosive pustular dermatosis of the scalp after aplasia cutis congenita in a 9-year-old patient: A 5-year follow-up

Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory skin disease that occurs mainly in elderly adults with a history of trauma to the scalp, but a few cases of EPDS in children have been reported. We report a rare case of EPDS after aplasia cutis congenita in a child