Resignificaci?n del concepto de evaluaci?n formativa como eje dinamizador de la labor de los docentes en la Instituci?n Educativa ?Luis Carlos Gal?n Sarmiento? de Honda

236 p. Recurso Electr?nicoEl presente trabajo de investigaci?n tuvo como objetivo diagnosticar las pr?cticas de evaluaci?n de los aprendizajes desarrolladas en la instituci?n educativa Luis Carlos Gal?n Sarmiento del municipio de Honda-Tolima, con el fin de proponer estrategias que fortalezcan la reflexi?n y la conceptualizaci?n para trasformar la evaluaci?n a partir de seis categor?as: Conceptos de evaluaci?n educativa y evaluaci?n de los aprendizajes, t?cnicas e instrumentos, usos, finalidades y principios. As? mismo se realiza un proceso de formaci?n a trav?s del plan Lector a partir de algunos referentes te?ricos con el fin de resignificar la evaluaci?n de los aprendizajes y mejorar los procesos evaluativos en la instituci?n educativa, se realizaron intervenciones al SIE y al plan de clase. El enfoque de la investigaci?n fue de tipo cualitativa, alcance descriptivo y dise?o Investigaci?n Acci?n Participaci?n, el cual permiti? transformar las pr?cticas de evaluaci?n de 23 docentes y de esta forma hacer un aporte a la comunidad acad?mica y a la comunidad educativa de la regi?n en torno al tema de la evaluaci?n que es tan importante en el proceso de ense?anza y aprendizaje y a la vez complejo. Palabras claves: Evaluaci?n formativa, Sistema de Evaluaci?n SIE, Plan lectorThis research had as objective to diagnose learning assessment practices developed in the educational institution Luis Carlos Gal?n Sarmiento in Honda - Tolima town in order to propose strategies that strengthen reflection and conceptualization to transform evaluation based on six categories: Concepts of educational evaluation and evaluation of learning, techniques and instruments, uses, purposes and principles. Likewise, a training process is carried out through the reader plan based on some theoretical references in order to resignify the evaluation of learning and improve the evaluation processes in the educational institution, interventions were made to the SIE and the class plan. The focus of the research was qualitative, descriptive and design Research Action Participation, which allowed to transform the evaluation practices of 23 teachers and in this way make a contribution to the academic community and the educational community of the region about evaluation that is so important and at the same time complex in the teaching and learning process. Keywords: Formative evaluation, Evaluation System SIE, Reader Pla

La relaci?n entre la CAG de derecho interno y las CAE de los CDI

Aquellas Cl?usulas Antielusivas Espec?ficas (?CAE?) de los Convenios para evitar la Doble Imposici?n (?CDI?), que tienen una estructura objetiva (?CAE propias?), establecen su alcance a trav?s de criterios espec?ficos (l?mites temporales, l?mites cuantitativos, exigencias verificables de manera formal como las caracter?sticas del receptor del pago, el accionariado del receptor del flujo, entre otros), no entran en conflicto con la Cl?usula Antielusiva General (?CAG?) de derecho interno. Un an?lisis distinto debe llevarse a cabo en relaci?n a las ?CAE impropias?, esto es, aquellas cl?usulas que, destinadas a un sector o tipo de renta espec?fico, comparten la naturaleza de la CAG en el sentido que se encuentran sustentadas en el criterio ?sustancia sobre forma? o ?realidad econ?mica?. S?lo en este caso la relaci?n se resuelve a trav?s del principio lex specialis derogat generali. Estas cl?usulas (CAE impropias) no implican ning?n tipo de regla de protecci?n al contribuyente, lo que nos parece grave, ya que su redacci?n utiliza terminolog?a vaga y ambigua (?principal prop?sito o uno de los principales prop?sitos?), y sin ninguna disposici?n de salvaguarda. Nuestro planteamiento sugiere criterios para proteger al contribuyente de la aplicaci?n de las referidas cl?usulas por parte de la autoridad tributaria

Fortaleciendo los h?bitos lectores implementando la literatura infantil como estrategia l?dico pedag?gica para enriquecer las habilidades comunicativas de los ni?os y ni?as del grado preescolar

116 p. Recurso Electr?nicoEl presente proyecto de investigaci?n centra su acci?n en estimular desde edades tempranas, la lectura y el acercamiento a los libros, como v?a para desarrollar h?bitos lectores y enriquecer las habilidades comunicativas. Tiene como objetivo fijar en el ni?o el h?bito de la lectura donde el principal factor es determinar aquellas posibles causas que propician o desmotivan a los ni?os el deseo de leer dentro de su mundo, aprender a tener un h?bito lector a temprana edad se ve como una necesidad en el desarrollo personal y social de cada uno de los ni?os, por eso vemos necesidad o alternativa de desarrollar estrategias l?dico pedag?gicas como la literatura infantil, por medio de un proyecto pedag?gico de aula para fortalecer h?bitos lectores, que le permitan transformar su inteligencia creadora, mejorar sus competencias comunicativas entre las que aparecen, leer, escribir, hablar y escuchar adem?s permite acercarlos de manera agradable a los textos. Conforme con esto, se tiene como referencia la investigaci?n formativa, de igual manera un modelo de investigaci?n cualitativo con enfoque etnogr?fico, con ?nfasis participativo y cooperativo, utilizando instrumentos como entrevistas, cuestionarios entre otros dentro del desarrollo del proyecto. El cual se llev? mediante dos fases, la primera se hizo mediante la observaci?n de la cual se detect? una problem?tica y la segunda en la cual se hizo una intervenci?n mediante el proyecto pedag?gico de aula, que dio paso a la participaci?n activa de toda una comunidad educativa. Palabras clave: literatura ? lectura ? h?bitos ? cuentos ? habilidades comunicativasThe present research project focuses on stimulating reading and the approaching to books from early ages, as a way to develop reading habits and enriching communicative skills. Its aim is to establish the habit of reading in children, where the main factor is to determine those possible causes that encourage or discourage children the desire to read within their world; learning to acquire a reading habit at an early age is seen as a necessity in the personal and social development of each child, thus, it is seen the necessity or alternative to implement dynamic-pedagogical strategies such as children's literature, through a pedagogical classroom project to strengthen reading habits, that allows him to transform his creative intelligence and to improve his communicative competences such as, reading, writing, speaking and listening; it also allows to connect them in a pleasant way to texts. Accordingly, the research is based on formative research, as well as a qualitative research model with an ethnographic approach, with a participative and cooperative emphasis, using instruments such as interviews, questionnaires and others within the project development. This was carried out in two phases: the first one was done through the observation in which a problematic was detected and the second one, where an intervention was made through the classroom pedagogical project, which gave way to the active participation of an entire educational community. Keywords: Literature - reading - habits - stories - communicative skill

Novel Mutation Hotspots within Non-Coding Regulatory Regions of the Chronic Lymphocytic Leukemia Genome

Mutations in non-coding DNA regions are increasingly recognized as cancer drivers. These mutations can modify gene expression in cis or by inducing high-order chormatin structure modifications with long-range effects. Previous analysis reported the detection of recurrent and functional non-coding DNA mutations in the chronic lymphocytic leukemia (CLL) genome, such as those in the 3' untranslated region of NOTCH1 and in the PAX5 super-enhancer. In this report, we used whole genome sequencing data produced by the International Cancer Genome Consortium in order to analyze regions with previously reported regulatory activity. This approach enabled the identification of numerous recurrently mutated regions that were frequently positioned in the proximity of genes involved in immune and oncogenic pathways. By correlating these mutations with expression of their nearest genes, we detected significant transcriptional changes in genes such as PHF2 and S1PR2. More research is needed to clarify the function of these mutations in CLL, particularly those found in intergenic regions

New Recurrent Structural Aberrations in the Genome of Chronic Lymphocytic Leukemia Based on Exome-Sequencing Data

Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative syndrome in Western countries, and it is characterized by recurrent large genomic rearrangements. During the last decades, array techniques have expanded our knowledge about CLL's karyotypic aberrations. The advent of large sequencing databases expanded our knowledge cancer genomics to an unprecedented resolution and enabled the detection of small-scale structural aberrations in the cancer genome. In this study, we have performed exome-sequencing-based copy number aberration (CNA) and loss of heterozygosity (LOH) analysis in order to detect new recurrent structural aberrations. We describe 54 recurrent focal CNAs enriched in cancer-related pathways, and their association with gene expression and clinical evolution. Furthermore, we discovered recurrent large copy number neutral LOH events affecting key driver genes, and we recapitulate most of the large CNAs that characterize the CLL genome. These results provide "proof-of-concept" evidence supporting the existence of new genes involved in the pathogenesis of CLL

ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet

The methylation levels of ZNF577 in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of ZNF577 depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of ZNF577 of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [n = 90; n = 64 (71.1%) overweight/obesity and n = 26 (28.9%) normal-weight] and paired tumor tissue biopsies (n = 8 breast cancer patients with obesity; n = 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the Sociedad Espanola de Nutricion Comunitaria. The methylation levels of ZNF577 were correlated between paired leukocytes and breast tumor biopsies (r = 0.62; p = 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity (p = 0.002) and postmenopausal patients (p = 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of ZNF577 methylation were also found in women with greater adherence to the Mediterranean diet (p = 0.017) or specific foods. Relevantly, the methylation levels of ZNF577 showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72; p = 0.016]. In conclusion, the association between methylation of ZNF577 and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of ZNF577 methylation in the association between breast cancer, adiposity and dietary patterns

An?lisis y evaluaci?n de la poblaci?n extramuros en los programas de Medio Libre

La Direcci?n de Medio Libre del INPE realiza programas al cual la poblaci?n penitenciaria extramuros accede m?nimamente en un 5.9% mientras que la reincidencia delictiva al 2018 fue de 25.6%, lo niveles de delincuencia se incrementa d?a a d?a y, por consiguiente, la poblaci?n Penitenciaria. En este contexto nuestro objetivo de investigaci?n es determinar la satisfacci?n de los programas en la poblaci?n penitenciaria extramuros, en los niveles psicol?gico, econ?mico y laboral. Los resultados de dicha encuesta determinaron que la mayor?a de la poblaci?n encuestada aprecia los programas por sus beneficios. Asimismo, un 25% afirma que sus gastos son mayores que sus ingresos. En su mayor?a, cuenta con un trabajo. Adem?s, el motivo por el cual asisten a los programas en un mayor porcentaje es por ?Cumplir Sentencia?, mientras muy pocos son ?Por Iniciativa?. A partir de dichos resultados seg?n la necesidad de fortalecer los programas CAPAS y FOCOS, se incorporen espacios de intermediaci?n laboral y se dise?en programas educativo y laboral focalizados en la poblaci?n extramuros

Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1

Finding novel targets in non-small cell lung cancer (NSCLC) is highly needed and identification of synthetic lethality between two genes is a new approach to target NSCLC. We previously found that TMPRSS4 promotes NSCLC growth and constitutes a prognostic biomarker. Here, through large-scale analyses across 5 public databases we identified consistent co-expression between TMPRSS4 and DDR1. Similar to TMPRSS4, DDR1 promoter was hypomethylated in NSCLC in 3 independent cohorts and hypomethylation was an independent prognostic factor of disease-free survival. Treatment with 5-azacitidine increased DDR1 levels in cell lines, suggesting an epigenetic regulation. Cells lacking TMPRSS4 were highly sensitive to the cytotoxic effect of the DDR1 inhibitor dasatinib. TMPRSS4/DDR1 double knock-down (KD) cells, but not single KD cells suffered a G0/G1 cell cycle arrest with loss of E2F1 and cyclins A and B, increased p21 levels and a larger number of cells in apoptosis. Moreover, double KD cells were highly sensitized to cisplatin, which caused massive apoptosis (~40%). In vivo studies demonstrated tumor regression in double KD-injected mice. In conclusion, we have identified a novel vulnerability in NSCLC resulting from a synthetic lethal interaction between DDR1 and TMPRSS4

Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling

BACKGROUND: Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this pathology, leading to the discovery of prognostic factors based on gene expression data, genomic rearrangements and mutational subgroups. Nevertheless, additional efforts are needed in order to enable survival predictions at the patient level. In this study we investigated new machine learning-based models of survival using transcriptomic and clinical data. METHODS: Gene expression profiling (GEP) of in 2 different publicly available retrospective DLBCL cohorts were analyzed. Cox regression and unsupervised clustering were performed in order to identify probes associated with overall survival on the largest cohort. Random forests were created to model survival using combinations of GEP data, COO classification and clinical information. Cross-validation was used to compare model results in the training set, and Harrel's concordance index (c-index) was used to assess model's predictability. Results were validated in an independent test set. RESULTS: Two hundred thirty-three and sixty-four patients were included in the training and test set, respectively. Initially we derived and validated a 4-gene expression clusterization that was independently associated with lower survival in 20% of patients. This pattern included the following genes: TNFRSF9, BIRC3, BCL2L1 and G3BP2. Thereafter, we applied machine-learning models to predict survival. A set of 102 genes was highly predictive of disease outcome, outperforming available clinical information and COO classification. The final best model integrated clinical information, COO classification, 4-gene-based clusterization and the expression levels of 50 individual genes (training set c-index, 0.8404, test set c-index, 0.7942). CONCLUSION: Our results indicate that DLBCL survival models based on the application of machine learning algorithms to gene expression and clinical data can largely outperform other important prognostic variables such as disease stage and COO. Head-to-head comparisons with other risk stratification models are needed to compare its usefulness