Web Based Postgraduate Thesis/Dessertation System - A Prototype

With the advancement of information communication technology in Malaysia, education field should take advantage to upgrade their learning and management techniques. Students should be allowed to learn anytime, anywhere and at their own place. However administration and lecture should be able to manage their work more effective and flexible. The web-based system is effective way to learning and managing education works. This report outlines the development of a web-based postgraduate thesis/dissertation management system (WPTS), which aimed to assist thesis/dissertation administration, supervisor and students in the better integration during students doing the thesis/dissertation works. This prototype system base on case study with a group of MSC(IT), administration, lecturer and students who participate in thesis/dissertation management activities. This report also presenting the tests conducted with users, it also contributed some perspective regarding benefits that gain by administration, supervisor and students, and recommends future application of the approach

Epilessia e gravidanza

In gravidanza la frequenza di crisi epilettiche aumenta nel 25% dei casi con conseguenze talvolta gravi. La terapia dell’epilessia si basa su farmaci che presentano effetti teratogeni: essi determinano spesso IUGR, inoltre i neonati da donne in terapia presentano spesso anomalie della coagulazione e sindrome da astinenza neonatale. Quando non è possibile interrompere la terapia, è preferibile la monoterapia, per ridurre il rischio di malformazione. La gravidanza va monitorata con controlli ecografici e dosaggio. Il parto potrà essere spontaneo con l’ausilio dell’anestesia peridurale per ridurre il rischio di crisi durante il travaglio. Il T.C. elettivo sarà programmato per le pazienti non collaboranti. L’allattamento materno non è sconsigliato, la quantità di farmaco presente nel latte è inferiore a quella cui il feto è stato esposto durante la gravidanza e riduce il rischio di insorgenza di sindrome da astinenza neonatale

A novel plasmonic sensor based on light-diffusing fibers with built-in measuring cell

In this work, a novel Surface Plasmon Resonance (SPR) sensor based on plastic light-diffusing fibers (LDFs) has been developed and investigated. The plasmonic platform structure includes an integrated measuring cell to avoid complex microfluidic systems and all the downsides that characterize them. In a first step, the developed sensor configuration has been optically tested in a refractive index range between 1.332 and 1.371 and then compared with other configurations. The obtained results have highlighted an improvement of about 40% in terms of bulk sensitivity with respect to a similar experimental configuration based on the same LDF but without modification, despite a slight worsening in terms of Full Width at Half Maximum (FWHM), whose value increases of about 20%. So, the obtained experimental results have denoted the possibility and feasibility of using this plasmonic configuration in biochemical sensing application fields. In particular, the proposed SPR sensor platform offers two key characteristics: a convenient measuring cell into the optical fiber and better sensitivity in the considered refractive index range. Furthermore, the plasmonic sensing region in the measuring cell can be combined with simple microfluidic systems or a dropping approach

The fifth cranial nerve in headaches

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists

Correction to: Patient-Reported Outcomes in an Observational Cohort of HIV-1-Infected Adults on Darunavir/Cobicistat-Based Regimens: Beyond Viral Suppression (The Patient - Patient-Centered Outcomes Research, (2020), 13, 3, (375-387), 10.1007/s40271-020-00413-y)

24noIn the original version of this article, in Fig. 2b the formatting on the x-axis of the graph has been published incorrectly.nonenoneAntinori A.; Cossu M.V.; Menzaghi B.; Sterrantino G.; Squillace N.; Di Cristo V.; Cattelan A.; Foca' E.; Castagna A.; Orofino G.; Valenti D.; D'Ettore G.; Aprea L.; Ferrara S.; Locatelli M.E.; Madeddu G.; Pontali E.; Scerbo P.; Rossetti B.; Uglietti A.; Termini R.; Rucci F.; Gori A.; Mancusi D.Antinori, A.; Cossu, M. V.; Menzaghi, B.; Sterrantino, G.; Squillace, N.; Di Cristo, V.; Cattelan, A.; Foca', E.; Castagna, A.; Orofino, G.; Valenti, D.; D'Ettore, G.; Aprea, L.; Ferrara, S.; Locatelli, M. E.; Madeddu, G.; Pontali, E.; Scerbo, P.; Rossetti, B.; Uglietti, A.; Termini, R.; Rucci, F.; Gori, A.; Mancusi, D

Patient-Reported Outcomes in an Observational Cohort of HIV-1-Infected Adults on Darunavir/Cobicistat-Based Regimens: Beyond Viral Suppression

Objective: This prospective, multicenter, non-interventional cohort study enrolling human immunodeficiency virus (HIV)-1-infected, virally suppressed adult outpatients in Italy aimed to describe results obtained from patient-reported outcome questionnaires regarding treatment satisfaction and symptom perceptions in HIV-1-positive patients who switched to cobicistat-boosted darunavir antiretroviral regimens, coming from ritonavir-boosted protease inhibitors. Methods: Patients entered this study between June 2016 and February 2017, once their treating physician had considered them eligible for cobicistat-boosted darunavir-based treatment as per clinical practice. Patients’ satisfaction regarding regimen and current symptom burdens were assessed using two previously validated, patient-reported outcome questionnaires: HIV Treatment Satisfaction Questionnaire (HIV-TSQ) and HIV Symptoms Distress Module (HIV-SDM). These questionnaires were administered at prespecified time-points: enrollment (Visit 1), 4–8 weeks later (Visit 2), and 48 ± 6 weeks after study enrollment (Visit 4). Data of patient-reported outcome total scores for both questionnaires are presented as median with 25th–75th percentiles. Questionnaires scores were analyzed overall and stratified by gender when applicable. A p value of less than 0.05 was considered statistically significant. A sensitivity analysis was conducted to evaluate the role of lost to follow-up, using the “last observation carried forward” method. Results: A total of 348 patients were enrolled in this study; 296 patients (208 male and 88 female) provided both evaluable HIV-TSQ and HIV-SDM at enrollment and at 4–8 weeks, while 250 patients (174 male and 76 female) provided questionnaire data at enrollment and at 48 ± 6 weeks. The total scores of HIV-TSQ showed improvements in patient satisfaction in the overall population both at Visit 2 and Visit 4 (p < 0.001, sign test) and also when stratified by gender throughout the study period. In addition, the overall burden of symptoms, as shown by the HIV-SDM scores, decreased. Conclusions: Switching to a cobicistat-boosted darunavir-based therapy led to overall increased patient satisfaction and reduced symptom burden when compared with previous regimens. The use of patient-reported outcomes in clinical daily practice could provide a useful tool towards achieving guideline goals to achieve “fourth 90”, having 90% of virally suppressed patients with a good health-related quality of life