Feedback from massive stars and gas expulsion from proto-globular clusters

© 2015. The American Astronomical Society. All rights reserved. Globular clusters (GCs) are considerably more complex structures than previously thought, harboring at least two stellar generations that present clearly distinct chemical abundances. Scenarios explaining the abundance patterns in GCs mostly assume that originally the clusters had to be much more massive than today, and that the second generation of stars originates from the gas shed by stars of the first generation (FG). The lack of metallicity spread in most GCs further requires that the supernova-enriched gas ejected by the FG is completely lost within ∼30 Myr, a hypothesis never tested by means of three-dimensional hydrodynamic simulations. In this paper, we use 3D hydrodynamic simulations including stellar feedback from winds and supernovae, radiative cooling and self-gravity to study whether a realistic distribution of OB associations in a massive proto-GC of initial mass M tot ∼ 10 7 M o is sufficient to expel its entire gas content. Our numerical experiment shows that the coherence of different associations plays a fundamental role: as the bubbles interact, distort, and merge, they carve narrow tunnels that reach deeper and deeper toward the innermost cluster regions, and through which the gas is able to escape. Our results indicate that after 3 Myr, the feedback from stellar winds is responsible for the removal of ∼40% of the pristine gas, and that after 14 Myr, 99% of the initial gas mass has been removed

Decoupled and inhomogeneous gas flows in S0 galaxies

A recent analysis of the "Einstein" sample of early-type galaxies has revealed that at any fixed optical luminosity Lb S0 galaxies have lower mean X-ray luminosity Lx per unit Lb than ellipticals. Following a previous analytical investigation of this problem (Ciotti & Pellegrini 1996), we have performed 2D numerical simulations of the gas flows inside S0 galaxies in order to ascertain the effectiveness of rotation and/or galaxy flattening in reducing the Lx/Lb ratio. The flow in models without SNIa heating is considerably ordered, and essentially all the gas lost by the stars is cooled and accumulated in the galaxy center. If rotation is present, the cold material settles in a disk on the galactic equatorial plane. Models with a time decreasing SNIa heating host gas flows that can be much more complex. After an initial wind phase, gas flows in energetically strongly bound galaxies tend to reverse to inflows. This occurs in the polar regions, while the disk is still in the outflow phase. In this phase of strong decoupling, cold filaments are created at the interface between inflowing and outflowing gas. Models with more realistic values of the dynamical quantities are preferentially found in the wind phase with respect to their spherical counterparts of equal Lb. The resulting Lx of this class of models is lower than in spherical models with the same Lb and SNIa heating. At variance with cooling flow models, rotation is shown to have only a marginal effect in this reduction, while the flattening is one of the driving parameters for such underluminosity, in accordance with the analytical investigation.Comment: 32 pages LaTex file, plus 5 .ps figures and macro aasms4.sty -- Accepted on Ap

Biological Applications of Synthetic Binders Isolated from a Conceptually New Adhiron Library

Background: Adhirons are small (10 kDa) synthetic ligands that might represent an alternative to antibody fragments and to alternative scaffolds such as DARPins or affibodies. Methods: We prepared a conceptionally new adhiron phage display library that allows the presence of cysteines in the hypervariable loops and successfully panned it against antigens possessing different characteristics. Results: We recovered binders specific for membrane epitopes of plant cells by panning the library directly against pea protoplasts and against soluble C-Reactive Protein and SpyCatcher, a small protein domain for which we failed to isolate binders using pre-immune nanobody libraries. The best binders had a binding constant in the low nM range, were produced easily in bacteria (average yields of 15 mg/L of culture) in combination with different tags, were stable, and had minimal aggregation propensity, independent of the presence or absence of cysteine residues in their loops. Discussion: The isolated adhirons were significantly stronger than those isolated previously from other libraries and as good as nanobodies recovered from a naïve library of comparable theoretical diversity. Moreover, they proved to be suitable reagents for ELISA, flow cytometry, the western blot, and also as capture elements in electrochemical biosensors

Diluting the material forming the second generation stars in Globular Clusters: the contribution by unevolved stars

In this short communication we consider the possibility that stars less evolved than the polluters are the source of the dilution needed to explain the observed composition of second-generation globular cluster (GC) stars and the Na-O and Mg-Al anticorrelations. If these stars can lose 0.5-1% of their mass during the relevant epochs, there is enough diluting material to produce the observed anticorrelations. In this case, the original mass of proto-GCs was several tens times higher than the current mass of GCs. While not strictly impossible, this is a stringent hypothesis that needs more support. Should this scenario be found true, then the link between the primordial (first-generation) population in GC and the field population would be very strong.Comment: Accepted for publication on Astronomy and Astrophysic

The HI content of Early-Type Galaxies from the ALFALFA survey I. Catalogued HI sources in the Virgo cluster

Aims: We are using the Arecibo Legacy Fast ALFA survey (ALFALFA), which is covering 17% of the sky at 21 cm, to study the HI content of Early-Type galaxies (ETG) in an unbiased way. The aim is to get an overall picture of the hot, warm and cold ISM of ETG, as a function of galaxy mass and environment, to understand its origin and fate, and to relate it to the formation and evolution history of these objects. Methods: This paper deals with the first part of our study, which is devoted to the 8-16 deg. declination strip in the Virgo cluster. In this sky region, using the Virgo Cluster Catalogue (VCC), we have defined an optical sample of 939 ETG, 457 of which are brighter than the VCC completeness limit at B_T=18.0. We have correlated this optical sample with the catalogue of detected HI sources from ALFALFA. Results: Out of the 389 ETG from the VCC with B_T<=18.0, outside the 1 deg. region of poor HI detection around M87, and corrected for background contamination of VCC galaxies without a known radial velocity, only 9 galaxies (2.3%) are detected in HI with a completeness limit of 3.5 and 7.6 x 10^7 Mo of HI for dwarf and giant ETG, respectively. In addition 4 VCC ETG with fainter magnitudes are also detected. Our HI detection rate is lower than previously claimed. The majority of the detected ETG appear to have peculiar morphology and to be located near the edges of the Virgo cluster. Conclusions: Our preliminary conclusion is that cluster ETG contain very little neutral gas, with the exceptions of a few peculiar dwarf galaxies at the edge of the ETG classification and of very few larger ETG, where the cold gas could have a recent external origin.Comment: Accepted for publication in Astronomy and Astrophysics; 6 pages, 3 figure

Microbiological and biochemical effectiveness of an antiseptic gel on the bacterial contamination of the inner space of dental implants: a 3-month human longitudinal study.

Microbial penetration inside the implant's internal cavity produces a bacterial reservoir that is associated with an area of inflamed connective tissue facing the fixture-abutment junction. The aim of this clinical trial is to evaluate the effectiveness of a 1% chlorhexidine gel on the internal bacterial contamination of implants with screw-retained abutments and on the level of AST secreted in peri-implant crevicular fluid. Twenty-five patients (aged 29 to 58 years) each received one implant. Three months after the end of the restorative treatment, and immediately after a clinical and radiographic examination and the abutment removal, microbiological samples were obtained from the internal part of each fixture and biochemical samples were collected by peri-implant sulci. The patients were then divided into two groups: the control (CG; n=10) and test (TG; n=15) groups. The CG had the abutment screwed into place and the crown cemented without any further intervention. In contrast, before the abutment placement and screw tightening, the TG had the internal part of the fixture filled with a 1% chlorhexidine gel. Three months later, the same clinical, microbiological and biochemical procedures were repeated in both groups. Total bacterial count, specific pathogens and AST activity were detected. The clinical parameters remained stable throughout the study. From baseline to the 3-month examination, the total bacterial counts underwent a significant reduction only in the TG. In contrast, the AST activity showed a significant increase in the CG. The administration of a 1% chlorhexidine gel appears to be an effective method for the reduction of bacterial colonization of the implant cavity and for safeguarding the health status of peri-implant tissue over a 3-month administration period

On the radial distribution of stars of different stellar generations in the globular cluster NGC 3201

We study the radial distribution of stars of different stellar generations in the globular cluster NGC 3201. From recently published multicolour photometry, a radial dependence of the location of stars on the giant branch was found. We coupled the photometric information to our sample of 100 red giants with Na, O abundances and known classification as first or second-generation stars. We find that giants stars of the second generation in NGC 3201 show a tendency to be more centrally concentrated than stars of the first generation, supporting less robust results from our spectroscopic analysis.Comment: Accepted for publication on Astronomy and Astrophysic

Perception of nurses’ professional identity during the first wave of COVID-19 pandemic infections

Background and aim of the work: The main purpose of this study is to investigate on the experience of nurses working in the Covid-19 area focusing on their role’s perception. In particular, we explored the nurses’ perception of job satisfaction in relation to the images sent back by public opinion through the mass media and social communication channels. During the first wave of Covid-19 nurses have acquired media visibility, but their feeling is represented more by the discomfort of finding themselves suddenly glorified in the face of a lack of professional, social, and economic recognition. Materials and methods: A Mix-Method methodology and convenience sampling was adopted, on the population of professionals and students in post-graduate specializations, belonging to the Department of Medicine and Surgery of the University of Parma, and by nurses from the ASST-Bergamo Est, Lombardia Italy, who worked in the Covid emergency during the first wave of the pandemic, from February 2020 to May 2020. In the quantitative phase Stamm’s Professional Quality of Life Scale - ProQOL was administered to 89 respondents through a Google Form, In the qualitative phase, 3 Focus Groups were conducted on a total of 17 students. Results: At the ProQOL questionnaire, a moderate score was found in the Compassion Satisfaction scale (CF = 38.28) and in the Secondary Traumatic Stress subscale (STS-24.33), while low values emerged in the Burnout subscale (BO = 16.02). Five specific topics emerged from the focus groups: Professional collaboration, Job satisfaction, Nurse’s personal skills, Failure to protect the public image and the nursing profession. Conclusions: The professional collaboration, union with the work team, sense of solidarity, job satisfaction, professional growth, and awareness of one’s role seem to have worked favorably on Compassion Satisfaction, while keeping Compassion Fatigue levels under control

Paving the way for the JWST: witnessing globular cluster formation at z>3

We report on five compact, extremely young (<10Myr) and blue (\beta_UV<-2.5, F_\lambda =\lambda^\beta) objects observed with VLT/MUSE at redshift 3.1169, 3.235, in addition to three objects at z=6.145. These sources are magnified by the Hubble Frontier Field galaxy clusters MACS~J0416 and AS1063. Their de-lensed half light radii (Re) are between 16 to 140pc, the stellar masses are ~1-20 X 10^6 Msun, the magnitudes are m_uv=28.8 - 31.4 (-17<Muv<-15) and specific star formation rates can be as large as ~800Gyr^-1. Multiple images of these systems are widely separated in the sky (up to 50'') and individually magnified by factors 3-40. Remarkably, the inferred physical properties of two objects are similar to those expected in some globular cluster formation scenarios, representing the best candidate proto-globular clusters (proto-GC) discovered so far. Rest-frame optical high dispersion spectroscopy of one of them at z=3.1169 yields a velocity dispersion \sigma_v~20km/s, implying a dynamical mass dominated by the stellar mass. Another object at z=6.145, with de-lensed Muv ~ -15.3 (m_uv ~ 31.4), shows a stellar mass and a star-formation rate surface density consistent with the values expected from popular GC formation scenarios. An additional star-forming region at z=6.145, with de-lensed m_uv ~ 32, a stellar mass of 0.5 X 10^6 Msun and a star formation rate of 0.06 Msun/yr is also identified. These objects currently represent the faintest spectroscopically confirmed star-forming systems at z>3, elusive even in the deepest blank fields. We discuss how proto-GCs might contribute to the ionization budget of the universe and augment Lya visibility during reionization. This work underlines the crucial role of JWST in characterizing the rest-frame optical and near-infrared properties of such low-luminosity high-z objects.Comment: 19 pages, 9 figures, 2 tables. MNRAS, version accepted by the refere

Advances in pre-treatment evaluation of pancreatic ductal adenocarcinoma: a narrative review

Background and Objective: Despite advances in the multidisciplinary management of pancreatic cancer, overall prognosis remains poor, due to early progression of the disease. There is a need to also take action in staging, to make it increasingly accurate and complete, to define the setting of the therapeutic strategy. This review was planned to update the current status of pre-treatment evaluation for pancreatic cancer. Methods: We conducted an extensive review, including relevant articles dealing with traditional imaging, functional imaging and minimally invasive surgical procedures before treatment for pancreatic cancer. We searched articles written in English only. Data in the PubMed database, published in the period between January 2000 and January 2022, were retrieved. Prospective observational studies, retrospective analyses and meta-analyses were reviewed and analysed. Key Content and Findings: Each imaging modality (endoscopic ultrasonography, endoscopic retrograde staging laparoscopy) has its own diagnostic advantages and limitations. The sensitivity, specificity and accuracy for each image set are reported. Data that support the increasing role of neoadjuvant therapy (radiotherapy and chemotherapy) and the meaning of a patient-tailored treatment selection, based on tumour staging, are also discussed. Conclusions: A multimodal pre-treatment workup should be searched as it improves staging accuracy, orienting patients with resectable tumors towards surgery, optimizing patient selection with locally advanced tumors to neoadjuvant or definite therapy and avoiding surgical resection or curative radiotherapy in those with metastatic disease