Modeling He-rich subdwarfs through the hot-flasher Scenario

We present 1D numerical simulations aimed at studying the hot-flasher scenario for the formation of He-rich subdwarf stars. Sequences were calculated for a wide range of metallicities and physical assumptions, such as the stellar mass at the moment of the helium core flash. This allows us to study the two previously proposed flavors of the hot-flasher scenario ("deep" and "shallow" mixing cases) and to identify a third transition type. Our sequences are calculated by solving simultaneously the mixing and burning equations within a diffusive convection picture, and in the context of standard mixing length theory. We are able to follow chemical evolution during deep-mixing events in which hydrogen is burned violently, and therefore able to present a homogeneous set of abundances for different metallicities and varieties of hot-flashers. We extend the scope of our work by analyzing the effects of non-standard assumptions, such as the effect of chemical gradients, extra-mixing at convective boundaries, possible reduction in convective velocities, or the interplay between difussion and mass loss. Particular emphasis is placed on the predicted surface properties of the models. We find that the hot-flasher scenario is a viable explanation for the formation and surface properties of He-sdO stars. Our results also show that, during the early He-core burning stage, element diffusion may produce the transformation of (post hot-flasher) He-rich atmospheres into He-deficient ones. If this is so, then we find that He-sdO stars should be the progenitors of some of the hottest sdB stars.Comment: 13 pages, including 8 figures and 6 tables. Accepted for publication in A&A. Replaced to match the final version, including a note added in proof regarding PG 1544+48

The ubiquitous nature of the Horizontal Branch second U-jump: A link with the Blue Hook scenario?

In a previous paper we reported on a discontinuity in the extreme horizontal branch (EHB) of the Galactic globular cluster NGC6752, which we called the second U-jump. This feature was attributed to a combination of post zero-age horizontal branch evolution and diffusion effects. In this follow-up study we analyze other EHB clusters and show that the second U-jump is a common feature among EHB clusters reaching T_{eff}\ge 23,000K, and that its onset in different clusters converges around T_{eff}\sim 21,000\pm3,000K. We also present near-ultraviolet diagrams of \omega Cen and NGC2808, the only two objects with spectroscopically confirmed ``blue hook'' stars (T_{eff}\ge 35,000K). We confirm predictions of a photometric discontinuity separating late from early-helium flashers. Moreover, we present empirical evidence that the second U-jump population might be mainly composed by early-helium flashers. Lastly, we revisit the discussion on the ubiquitous nature of the gaps and jumps so far identified in the blue HB tails, suggesting a possible discrete nature of the distribution in temperature of the HB stars.Comment: 15 pages, 8 figures. Higher resolution version available via ftp at ftp://ftp.pd.astro.it/pub/momany/momany.tar A&A accepte

The clinical assessment study of the foot (CASF): study protocol for a prospective observational study of foot pain and foot osteoarthritis in the general population.

BACKGROUND: Symptomatic osteoarthritis (OA) affects approximately 10% of adults aged over 60 years. The foot joint complex is commonly affected by OA, yet there is relatively little research into OA of the foot, compared with other frequently affected sites such as the knee and hand. Existing epidemiological studies of foot OA have focussed predominantly on the first metatarsophalangeal joint at the expense of other joints. This three-year prospective population-based observational cohort study will describe the prevalence of symptomatic radiographic foot OA, relate its occurrence to symptoms, examination findings and life-style-factors, describe the natural history of foot OA, and examine how it presents to, and is diagnosed and managed in primary care. METHODS: All adults aged 50 years and over registered with four general practices in North Staffordshire, UK, will be invited to participate in a postal Health Survey questionnaire. Respondents to the questionnaire who indicate that they have experienced foot pain in the preceding twelve months will be invited to attend a research clinic for a detailed clinical assessment. This assessment will consist of: clinical interview; physical examination; digital photography of both feet and ankles; plain x-rays of both feet, ankles and hands; ultrasound examination of the plantar fascia; anthropometric measurement; and a further self-complete questionnaire. Follow-up will be undertaken in consenting participants by postal questionnaire at 18 months (clinic attenders only) and three years (clinic attenders and survey participants), and also by review of medical records. DISCUSSION: This three-year prospective epidemiological study will combine survey data, comprehensive clinical, x-ray and ultrasound assessment, and review of primary care records to identify radiographic phenotypes of foot OA in a population of community-dwelling older adults, and describe their impact on symptoms, function and clinical examination findings, and their presentation, diagnosis and management in primary care

Discovery of a rapidly pulsating subdwarf B star candidate in omega Cen

We report the discovery of the first variable extreme horizontal branch star in a globular cluster (omega Cen). The oscillation uncovered has a period of 114 s and an amplitude of 32 mmags. A comparison between horizontal branch models and observed optical colours indicates an effective temperature of 31,500+-6,300 K for this star, placing it within the instability strip for rapidly oscillating B subdwarfs. The time scale and amplitude of the pulsation detected are also in line with what is expected for this type of variable, thus strengthening the case for the discovery of a new subdwarf B pulsator.Comment: 5 pages, 7 figures; accepted for publication in A&

How the vision of a clinician and an educator brought the MA Dental Law and Ethics course to life.

This paper reflects on an educational development that is Dental Law and Ethics course as the course approaches its 5th anniversary. The authors outline their personal journey into developing and delivering this course as well share best practice in relation to teaching and learning dental postgraduate students who may approach the subject in different ways. It also highlights the vision behind this provision and how it is received by dental practitioners. The paper shares the learners’ perception of topics such as ethics in comparison to law, and it highlights the perspective of both authors in teaching and following the students’ journey in this course

Observations and asteroseismological analysis of the rapid subdwarf B pulsator EC 09582-1137

We made photometric and spectroscopic observations of the rapidly pulsating subdwarf B star EC 09582-1137 with the aim of determining the target's fundamental structural parameters from asteroseismology. The new data comprise ~ 30 hours of fast time-series photometry obtained with SUSI2 at the NTT on La Silla, Chile, as well as 1 hour of low-resolution spectroscopy gathered with EMMI, also mounted on the NTT. From the photometry we detected 5 independent harmonic oscillations in the 135-170 s period range with amplitudes up to 0.5% of the mean brightness of the star. In addition, we extracted two periodicities interpreted as components of a rotationally split multiplet that indicate a rotation period of the order of 2-5 days. We also recovered the first harmonic of the dominant pulsation, albeit at an amplitude below the imposed 4-sigma detection threshold. The spectroscopic observations led to the following estimates of the atmospheric parameters of EC 09582-1137: Teff = 34,806+-233 K, log g = 5.80+-0.04, and log[N(He)/N(H)] = - 1.68+-0.06. Using the observed oscillations as input, we searched in model parameter space for unique solutions that present a good fit to the data. Under the assumption that the two dominant observed periodicities correspond to radial or dipole modes, we were able to isolate a well-constrained optimal model that agrees with the atmospheric parameters derived from spectroscopy. The inferred structural parameters of EC 09582-1137 are Teff = 34,806 K (from spectroscopy), log g = 5.788+-0.004, M = 0.485+-0.011 M_solar, log(M_env/M_star) = - 4.39+-0.10, R = 0.147+-0.002 R_solar, and L = 28.6+-1.7 L_solar. We additionally derive the absolute magnitude M_V = 4.44+-0.05 and the distance d = 1460+-66 pc.Comment: accepted for publication in Astronomy and Astrophysic

Clinical and Laboratory Associations with Methotrexate Metabolism Gene Polymorphisms in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that causes loss of joint function and significantly reduces quality of life. Plasma metabolite concentrations of disease-modifying anti-rheumatic drugs (DMARDs) can influence treatment efficacy and toxicity. This study explored the relationship between DMARD-metabolising gene variants and plasma metabolite levels in RA patients. DMARD metabolite concentrations were determined by tandem mass-spectrometry in plasma samples from 100 RA patients with actively flaring disease collected at two intervals. Taqman probes were used to discriminate single-nucleotide polymorphism (SNP) genotypes in cohort genomic DNA: rs246240 (ABCC1), rs1476413 (MTHFR), rs2231142 (ABCG2), rs3740065 (ABCC2), rs4149081 (SLCO1B1), rs4846051 (MTHFR), rs10280623 (ABCB1), rs16853826 (ATIC), rs17421511 (MTHFR) and rs717620 (ABCC2). Mean plasma concentrations of methotrexate (MTX) and MTX-7-OH metabolites were higher (p < 0.05) at baseline in rs4149081 GA genotype patients. Patients with rs1476413 SNP TT or CT alleles have significantly higher (p < 0.001) plasma poly-glutamate metabolites at both study time points and correspondingly elevated disease activity scores. Patients with the rs17421511 SNP AA allele reported significantly lower pain scores (p < 0.05) at both study intervals. Genotyping strategies could help prioritise treatments to RA patients most likely to gain clinical benefit whilst minimizing toxicity

Very low mass white dwarfs with a C-O core

The lower limit for the mass of white dwarfs (WDs) with C-O core is commonly assumed to be roughly 0.5 Msun. As a consequence, WDs of lower masses are usually identified as He-core remnants. However, when the initial mass of the progenitor star is in between 1.8 and 3 Msun, which corresponds to the so called red giant (RGB) phase transition, the mass of the H-exhausted core at the tip of the RGB is 0.3 < M_H/Msun < 0.5. Prompted by this well known result of stellar evolution theory, we investigate the possibility to form C-O WDs with mass M < 0.5 Msun. The pre-WD evolution of stars with initial mass of about 2.3 Msun, undergoing anomalous mass-loss episodes during the RGB phase and leading to the formation of WDs with He-rich or CO-rich cores have been computed. The cooling sequences of the resulting WDs are also described. We show that the minimum mass for a C-O WD is about 0.33 Msun, so that both He and C-O core WDs can exist in the mass range 0.33-0.5 Msun. The models computed for the present paper provide the theoretical tools to indentify the observational counterpart of very low mass remnants with a C-O core among those commonly ascribed to the He-core WD population in the progressively growing sample of observed WDs of low mass. Moreover, we show that the central He-burning phase of the stripped progeny of the 2.3 Msun star lasts longer and longer as the total mass decreases. In particular, the M= 0.33 Msun model takes about 800 Myr to exhausts its central helium, which is more than three time longer than the value of the standard 2.3 Msun star: it is, by far, the longest core-He burning lifetime. Finally, we find the occurrence of gravonuclear instabilities during the He-burning shell phase.Comment: Accepted for publication in Astronomy and Astrophysics, 9 page