490 research outputs found
Planck LFI flight model feed horns
this paper is part of the Prelaunch status LFI papers published on JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/jinst The Low Frequency
Instrument is optically interfaced with the ESA Planck telescope through 11
corrugated feed horns each connected to the Radiometer Chain Assembly (RCA).
This paper describes the design, the manufacturing and the testing of the
flight model feed horns. They have been designed to optimize the LFI optical
interfaces taking into account the tight mechanical requirements imposed by the
Planck focal plane layout. All the eleven units have been successfully tested
and integrated with the Ortho Mode transducers.Comment: This is an author-created, un-copyedited version of an article
accepted for publication in JINST. IOP Publishing Ltd is not responsible for
any errors or omissions in this version of the manuscript or any version
derived from it. The definitive publisher authenticated version is available
online at 10.1088/1748-0221/4/12/T1200
Repetitive low-frequency stimulation reduces epileptiform synchronization in limbic neuronal networks.
Deep-brain electrical or transcranial magnetic stimulation may represent a therapeutic tool for controlling seizures in patients presenting with epileptic disorders resistant to antiepileptic drugs. In keeping with this clinical evidence, we have reported that repetitive electrical stimuli delivered at approximately 1 Hz in mouse hippocampus-entorhinal cortex (EC) slices depress the EC ability to generate ictal activity induced by the application of 4-aminopyridine (4AP) or Mg2+-free medium (Barbarosie, M., Avoli, M., 1997. CA3-driven hippocampal–entorhinal loop controls rather than sustains in vitro limbic seizures. J. Neurosci. 17, 9308–9314.). Here, we confirmed a similar control mechanism in rat brain slices analyzed with field potential recordings during 4AP (50 μM) treatment. In addition, we used intrinsic optical signal (IOS) recordings to quantify the intensity and spatial characteristics of this inhibitory influence. IOSs reflect the changes in light transmittance throughout the entire extent of the slice, and are thus reliable markers of limbic network epileptiform synchronization. First, we found that in the presence of 4AP, the IOS increases, induced by a train of electrical stimuli (10 Hz for 1 s) or by recurrent, single-shock stimulation delivered at 0.05 Hz in the deep EC layers, are reduced in intensity and area size by low-frequency (1 Hz), repetitive stimulation of the subiculum; these effects were observed in all limbic areas contained in the slice. Second, by testing the effects induced by repetitive subicular stimulation at 0.2–10 Hz, we identified maximal efficacy when repetitive stimuli are delivered at 1 Hz. Finally, we discovered that similar, but slightly less pronounced, inhibitory effects occur when repetitive stimuli at 1 Hz are delivered in the EC, suggesting that the reduction of IOSs seen during repetitive stimulation is pathway dependent as well as activity dependent. Thus, the activation of limbic networks at low frequency reduces the intensity and spatial extent of the IOS changes that accompany ictal synchronization in an in vitro slice preparation. This conclusion supports the view that repetitive stimulation may represent a potential therapeutic tool for controlling seizures in patients with pharmacoresistant epileptic disorders
The Planck-LFI flight model composite waveguides
The Low Frequency Instrument on board the PLANCK satellite is designed to
give the most accurate map ever of the CMB anisotropy of the whole sky over a
broad frequency band spanning 27 to 77 GHz. It is made of an array of 22
pseudo-correlation radiometers, composed of 11 actively cooled (20 K) Front End
Modules (FEMs), and 11 Back End Modules (BEMs) at 300K. The connection between
the two parts is made with rectangular Wave Guides. Considerations of different
nature (thermal, electromagnetic and mechanical), imposed stringent
requirements on the WGs characteristics and drove their design. From the
thermal point of view, the WG should guarantee good insulation between the FEM
and the BEM sections to avoid overloading the cryocooler. On the other hand it
is essential that the signals do not undergo excessive attenuation through the
WG. Finally, given the different positions of the FEM modules behind the focal
surface and the mechanical constraints given by the surrounding structures,
different mechanical designs were necessary. A composite configuration of
Stainless Steel and Copper was selected to satisfy all the requirements. Given
the complex shape and the considerable length (about 1.5-2 m), manufacturing
and testing the WGs was a challenge. This work deals with the development of
the LFI WGs, including the choice of the final configuration and of the
fabrication process. It also describes the testing procedure adopted to fully
characterize these components from the electromagnetic point of view and the
space qualification process they underwent. Results obtained during the test
campaign are reported and compared with the stringent requirements. The
performance of the LFI WGs is in line with requirements, and the WGs were
successfully space qualified.Comment: this paper is part of the Prelaunch status LFI papers published on
JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/jins
Planck-LFI radiometers' spectral response
The Low Frequency Instrument (LFI) is an array of pseudo-correlation
radiometers on board the Planck satellite, the ESA mission dedicated to
precision measurements of the Cosmic Microwave Background. The LFI covers three
bands centred at 30, 44 and 70 GHz, with a goal bandwidth of 20% of the central
frequency.
The characterization of the broadband frequency response of each radiometer
is necessary to understand and correct for systematic effects, particularly
those related to foreground residuals and polarization measurements. In this
paper we present the measured band shape of all the LFI channels and discuss
the methods adopted for their estimation. The spectral characterization of each
radiometer was obtained by combining the measured spectral response of
individual units through a dedicated RF model of the LFI receiver scheme.
As a consistency check, we also attempted end-to-end spectral measurements of
the integrated radiometer chain in a cryogenic chamber. However, due to
systematic effects in the measurement setup, only qualitative results were
obtained from these tests. The measured LFI bandpasses exhibit a moderate level
of ripple, compatible with the instrument scientific requirements.Comment: 16 pages, 9 figures, this paper is part of the Prelaunch status LFI
papers published on JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/jins
Amyloid prefibrillar oligomers: The surprising commonalities in their structure and activity
It has been proposed that a "common core" of pathologic pathways exists for the large family of amyloid-associated neurodegenerations, including Alzheimer's, Parkinson's, type II diabetes and Creutzfeldt-Jacob's Disease. Aggregates of the involved proteins, independently from their primary sequence, induced neuron membrane permeabilization able to trigger an abnormal Ca2+ influx leading to synaptotoxicity, resulting in reduced expression of synaptic proteins and impaired synaptic transmission. Emerging evidence is now focusing on low-molecular-weight prefibrillar oligomers (PFOs), which mimic bacterial pore-forming toxins that form well-ordered oligomeric membrane-spanning pores. At the same time, the neuron membrane composition and its chemical microenvironment seem to play a pivotal role. In fact, the brain of AD patients contains increased fractions of anionic lipids able to favor cationic influx. However, up to now the existence of a specific "common structure" of the toxic aggregate, and a "common mechanism" by which it induces neuronal damage, synaptotoxicity and impaired synaptic transmission, is still an open hypothesis. In this review, we gathered information concerning this hypothesis, focusing on the proteins linked to several amyloid diseases. We noted commonalities in their structure and membrane activity, and their ability to induce Ca2+ influx, neurotoxicity, synaptotoxicity and impaired synaptic transmission
High Performances Corrugated Feed Horns for Space Applications at Millimetre Wavelengths
We report on the design, fabrication and testing of a set of high performance
corrugated feed horns at 30 GHz, 70 GHz and 100 GHz, built as advanced
prototypes for the Low Frequency Instrument (LFI) of the ESA Planck mission.
The electromagnetic designs include linear (100 GHz) and dual shaped (30 and 70
GHz) profiles. Fabrication has been achieved by direct machining at 30 GHz, and
by electro-formation at higher frequencies. The measured performances on side
lobes and return loss meet the stringent Planck requirements over the large
(20%) instrument bandwidth. Moreover, the advantage in terms of main lobe shape
and side lobes levels of the dual profiled designs has been demonstrated.Comment: 16 pages, 7 figures, accepted for publication in Experimental
Astronom
The linearity response of the Planck-LFI flight model receivers
In this paper we discuss the linearity response of the Planck-LFI receivers,
with particular reference to signal compression measured on the 30 and 44 GHz
channels. In the article we discuss the various sources of compression and
present a model that accurately describes data measured during tests performed
with individual radiomeric chains. After discussing test results we present the
best parameter set representing the receiver response and discuss the impact of
non linearity on in-flight calibration, which is shown to be negligible.Comment: this paper is part of the Prelaunch status LFI papers published on
JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/jinst; This is an
author-created, un-copyedited version of an article accepted for publication
in JINST. IOP Publishing Ltd is not responsible for any errors or omissions
in this version of the manuscript or any version derived from it. The
definitive publisher authenticated version is available online at
10.1088/1748-0221/4/12/T12011
Split crest technique for implant treatment of agenesis of the upper lateral incisors: results of a randomized pilot histological and clinical study at 24-month follow-up
Agenesis of lateral incisors, besides the functional issues, represents a great esthetic drawback. The selection of an appropriate treatment is a complex decision, which should consider the stability of the clinical outcomes over time. The aim of the present study was a histological and clinical comparison of two-stage split crest technique (SCT), with bone chips alone or mixed with porcine bone in patients affected by unilateral and bilateral agenesis of the upper lateral incisors. Eleven patients were enrolled, and randomly assigned to receive a treatment with autologous bone chips (group 1) or autologous bone chips mixed 1:1 to porcine-derived xenogenic bone (group 2). After a 2-month healing period, implants were placed and biopsies harvested for histomorphometrical evaluation. Clinical assessment, according to ICOI PISA health scale, and radiographic marginal bone loss evaluation at 12- and 24-month follow-ups were conducted. The histomorphometry showed significantly greater new bone formation (p > 0.0229) in group 2. At 12- and 24-month follow-ups, all the evaluated implants, regardless of the group they were allocated, could be categorized as "success" in the ICOI Pisa Health Scale for Dental Implants, and did not show significant difference in crestal bone loss. To the best of our knowledge, these are the first histological and clinical outcomes indicating that the use of bone chips mixed 1:1 to porcine bone in SCT could be a promising technique for the rehabilitation of patients with agenesis of the upper lateral incisors, although studies with a larger number of patients and implants, and a longer follow up are needed
Empathic and cognitive processing in people with schizophrenia: a study on an Italian sample
The aim of this study was to explore the relationships among empathy processes in terms of self-report empathy evaluation and recognition of emotional cues and Theory of Mind components. We used the Empathy Quotient – short form (EQ-s), the Pictures of Facial Affect (POFA) system, a (ToM) Irony appreciation task and the Wisconsin Card Sorting Test (WCST), respectively. The Positive and Negative Symptoms Scale (PANSS) and Global Assessment of Functioning (GAF) were also used to investigate the relationship with symptomatology and functioning. The sample consisted of 30 participants with diagnosis of schizophrenia. Our results found no significant correlations between EQ-s and other cognitive or clinical variables. PoFA total score and recognition of fear correlated with time spent to give a correct response to the ToM irony comprehension. Time spent to correctly respond to both ToM and physical vignettes correlated with negative symptoms. Positive, negative and cognitive clusters of the PANSS correlated with the GAF. The relationships we found among the considered constructs suggest that empathic processing acts on functionality improving the personal efficiency, in terms of readiness and rapidity, to cope with one’s environment, in the multifaceted social setting. Given that emotion perception in particular has been connected to social competence, independent living and community functioning, it is conceivable that emotion processing may be a potential catalyst within the mindreading process, which can have an impact both on symptomatology and social functioning
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